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LYNX1 encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Zusätzlich bieten wir Ihnen Ly6/neurotoxin 1 Antikörper (4) und viele weitere Produktgruppen zu diesem Protein an.
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These results indicated that SLURP-2 competes with acetylcholine predominantly at the alpha3 nAChR (zeige CHRNA4 Proteine), and that receptor ligation with SLURP-2 delays keratinocyte differentiation and prevents apoptosis.
anti-tumorigenic activities of SLURP-1 (zeige SLURP1 Proteine) and -2 were demonstrated both in vitro and in vivo.
SLURP-2 downregulated TNFalpha (zeige TNF Proteine) and IFNgamma R in T-cells and reduced IL-6 (zeige IL6 Proteine) production by macrophage
These findings provide new insights into the acetylcholine receptor (zeige CHRNA1 Proteine)-mediated regulatory mechanism of SLURP-2 expression in keratinocytes.
These studies suggest that lynx1 is a potential target both for development of drugs that may limit lung cancer growth as well as for drugs that may be effective for asthma or COPD (zeige ARCN1 Proteine) treatment.
This epigenome-wide DNA methylation (zeige HELLS Proteine) analysis in postmortem hippocampus and prefrontal cortex specimens confirmed LYNX1 DNA methylation (zeige HELLS Proteine) profiles in major depression.
Micromolar affinities and fast washout rates measured for ws-LYNX1 and its mutants are in contrast to nanomolar affinities and irreversibility of binding for alpha-bungarotoxin and similar snake alpha-neurotoxins also targeting alpha7 nAChR (zeige CHRNA7 Proteine).
Computer modeling, based on ws-LYNX1 NMR structure and AChBP x-ray structure, revealed a possible mode of ws-LYNX1 binding.
LY-6K (zeige Ly6k Proteine),a novel member protein of the Ly-6/uPAR (zeige PLAUR Proteine) superfamily, is a significant new molecular marker for diagnosis and gene therapy in patients with breast cancer.
decreased Lynx1 is associated with squamous cell lung carcinoma
The results of this study suggested greater spine loss as a better correlate of elevated functional plasticity in adult Lynx1-KO mice.
tPA (zeige PLAT Proteine) activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity.
lynx1 KO animals over 1 year of age have clear ultrastructural differences in the striatum.
Lynx1 has a role in shifting alpha4beta2 nicotinic receptor subunit stoichiometry by affecting assembly in the endoplasmic reticulum
study identified an increase in expression of Lynx1 protein that prevented plasticity in the primary visual cortex late in life; Lynx1 expression maintains stability of mature cortical networks in the presence of cholinergic innervation
Results show that lynx1 colocalizes with nAChRs on CNS neurons and physically associates with nAChRs and enhances receptor desensitization, resulting in a novel type of functional modulation
Lynx1 appears to act as a negative modulator of alpha7 nAChR (zeige CHRNA7 Proteine)-induced events by inhibiting Src (zeige SRC Proteine) activation.
This gene encodes a member of the Ly-6/neurotoxin gene family, a group of lymphocyte antigens that attach to the cell surface by a glycosylphosphatidylinositol anchor and have a unique structure showing conserved 8-10 cysteine residues with a characteristic spacing pattern. Functional analysis indicates that this protein is not a ligand or neurotransmitter but has the capacity to enhance nicotinic acetylcholine receptor function in the presence of acetylcholine. This gene may also play a role in the pathogenesis of psoriasis vulgaris. Alternatively spliced variants encoding different isoforms have been identified.
Ly-6 neurotoxin-like protein 1
, ly-6/neurotoxin-like protein 1
, secreted Ly-6/uPAR domain-containing protein 2
, secreted Ly-6/uPAR-related protein 2
, secreted Ly6/uPAR related protein 2
, secreted Ly6/uPAR related protein-2