Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kits

The protein encoded by LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. Zusätzlich bieten wir Ihnen LDLRAP1 Antikörper (129) und LDLRAP1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
LDLRAP1 26119 Q5SW96
LDLRAP1 100017 Q8C142
Anti-Ratte LDLRAP1 LDLRAP1 500564  
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Top LDLRAP1 ELISA Kits auf antikoerper-online.de

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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus 0.067 ng/mL 0.156-10 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
896,09 €
Details
Human 4.68 pg/mL 18.75-1200 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
772,39 €
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Weitere ELISA Kits für LDLRAP1 Interaktionspartner

Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Interaktionspartner

  1. LDLRAP1 associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age /=160 mg/dl.

  2. Numb (zeige NUMB ELISA Kits) specifically regulates NPC1L1 (zeige NPC1L1 ELISA Kits)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2 (zeige DAB2 ELISA Kits), which selectively participate in LDLR (zeige LDLR ELISA Kits)-mediated LDL uptake.

  3. Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]

  4. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  5. This work identified a combined LDL receptor (zeige LDLR ELISA Kits) and LDLRAP1 mutation as the cause for severe familial hypercholesterolemia in a family of Turkish descent.

  6. The report provides evidence that endocytosis of the ROMK potassium channel is controlled by LDLRAP1 (ARH). ROMK binds directly to the LDLRAP1, and this interaction is mediated by a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV. LDLRAP1-knockout mice are unable to physiologically regulate ROMK.

  7. report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB (zeige PTBP1 ELISA Kits)) domain of ARH in complex with an LDLR (zeige LDLR ELISA Kits) tail peptide containing the FxNPxY(0) internalization signal

  8. LDL receptor (zeige LDLR ELISA Kits)/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.

  9. ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 (zeige LMNB1 ELISA Kits) or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.

  10. Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR (zeige LDLR ELISA Kits), which encodes only the FxNPxY motif (LDLR (zeige LDLR ELISA Kits)-CT27 (zeige CTCFL ELISA Kits)).

Mouse (Murine) Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Interaktionspartner

  1. The combination of Arh and Dab2 (zeige DAB2 ELISA Kits) is responsible for the majority of adaptor function in LDLR (zeige LDLR ELISA Kits) endocytosis and LDLR (zeige LDLR ELISA Kits)-mediated cholesterol homeostasis.

  2. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  3. results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor (zeige LDLR ELISA Kits) endocytosis in the liver

  4. Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR (zeige LDLR ELISA Kits) is not cell-specific, but rather may depend on the cellular environment.

  5. the LDL receptor (zeige LDLR ELISA Kits) alone can account for the clearance of apoE (zeige APOE ELISA Kits)-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either increase the sensitivity to apoE (zeige APOE ELISA Kits)-induced hypertriglyceridemia in mice.

  6. Taken together, our data suggest that ARH is a multifunctional protein whose spectrum of function in the brain goes beyond the traditionally known metabolism of lipoproteins, and that ARH may be locally synthesized in the axon.

  7. the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis

  8. Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor (zeige LDLR ELISA Kits)

  9. ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis

LDLRAP1 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Genbezeichner und Symbole assoziert mit LDLRAP1

  • low density lipoprotein receptor adaptor protein 1 (ldlrap1) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (LDLRAP1) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (LOC100342213) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (Ldlrap1) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (ldlrap1-b) Antikörper
  • low density lipoprotein receptor adaptor protein 1 (ldlrap1-a) Antikörper
  • low density lipoprotein receptor adaptor protein 1a (ldlrap1a) Antikörper
  • AA691260 Antikörper
  • Arh Antikörper
  • Arh1 Antikörper
  • ARH2 Antikörper
  • FHCB1 Antikörper
  • FHCB2 Antikörper
  • ldlrap1 Antikörper
  • RGD1563417 Antikörper
  • sb:cb50 Antikörper
  • xptb Antikörper
  • zgc:56121 Antikörper

Bezeichner auf Proteinebene für LDLRAP1

low density lipoprotein receptor adaptor protein 1 , low-density lipoprotein adaptor protein , low density lipoprotein receptor adapter protein 1 , LDL receptor adaptor protein , autosomal recessive hypercholesterolemia protein , autosomal recessive hypercholesterolemia protein homolog , ARH beta , autosomal recessive hypercholesterolemia protein homolog beta , low density lipoprotein receptor adapter protein 1-B , xARH beta , ARH alpha , autosomal recessive hypercholesterolemia protein homolog alpha , low density lipoprotein receptor adapter protein 1-A , phosphotyrosine binding protein , phosphotyrosine-binding protein , xARH alpha , xcat4

GENE ID SPEZIES
549868 Xenopus (Silurana) tropicalis
739347 Pan troglodytes
100125967 Sus scrofa
100342213 Oryctolagus cuniculus
511199 Bos taurus
26119 Homo sapiens
612219 Canis lupus familiaris
100017 Mus musculus
500564 Rattus norvegicus
414519 Xenopus laevis
419589 Gallus gallus
398568 Xenopus laevis
368278 Danio rerio
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