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LARGE, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. Zusätzlich bieten wir Ihnen Like-Glycosyltransferase Proteine (6) und Like-Glycosyltransferase Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 40 products:
Cow (Bovine) Polyclonal LARGE Primary Antibody für ELISA - ABIN4229228
de Bernabé, Inamori, Yoshida-Moriguchi, Weydert, Harper, Willer, Henry, Campbell: Loss of alpha-dystroglycan laminin binding in epithelium-derived cancers is caused by silencing of LARGE. in The Journal of biological chemistry 2009
This study suggests LARGE as the first known modifier of plasma antithrombin (zeige SERPINC1 Antikörper).
results reveal that the LARGE-glycan of dystroglycan serves as a tunable extracellular matrix protein scaffold, the extension of which is required for normal skeletal muscle function
LARGE could act as a bifunctional glycosyltransferase (zeige GTDC2 Antikörper), with xylosyltransferase and glucuronyltransferase activities, which produced repeating units of [-3-xylose-alpha1,3-glucuronic acid-beta1-]; allowed alpha-DG to bind laminin-G domain-containing ECM (zeige MMRN1 Antikörper) ligands
the ligand-binding activity of alpha-dystroglycan is conferred primarily by LARGE modification at Thr (zeige TRH Antikörper)-317 and -319, within the highly conserved first 18 amino acids of the mucin (zeige SLC13A2 Antikörper)-like domain
LARGE2 (zeige GYLTL1B Antikörper) was found to support the maturation of alpha-dystroglycan more effectively than LARGE.
LARGE repression is responsible for the defects in dystroglycan-mediated cell adhesion that are observed in epithelium-derived cancer cells and point to a defect of dystroglycan glycosylation as a factor in cancer progression
data suggest LARGE overexpression may only be deleterious under a forced regenerative context, such as that resulting from a reduction in FKRP (zeige FKRP Antikörper): in the absence of such a defect we show that systemic expression of LARGE can indeed act therapeutically, and that even dramatic LARGE overexpression is well-tolerated in heart and skeletal muscle
MBP1 (zeige ENO1 Antikörper) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (zeige ENO1 Antikörper) to reduce Ab pathology and improve behavioral performance.
The overexpression of LARGE aggravates muscular dystrophy by suppressing the muscle regeneration and this adverse effect is mediated via reduced expression of IGF-1 (zeige IGF1 Antikörper).
Endogenous glucuronyltransferase activity of LARGE or LARGE2 (zeige GYLTL1B Antikörper) required for functional modification of alpha-dystroglycan in cells and tissues.
The overexpression of LARGE leads to a shortened lifespan and worsening of the FKRP (zeige FKRP Antikörper)-MD phenotype
blocking Large during muscle regeneration results in synthesis of dystroglycan with minimal LARGE-glycan repeats in association with less compact basement membrane, immature neuromuscular junctions, and dysfunctional muscle predisposed to dystrophy
Muscular dystrophy defects are primarily due to the effects of LARGE and glycosylated dystroglycan in stabilizing the endplate of the neuromuscular junction.
Differential glycosylation of alpha-dystroglycan and proteins other than alpha-dystroglycan by like-glycosyltransferase.
a mechanism by which Large competes with galactosyltransferase to target GlcNAc terminals to induce the functional glycans on alpha-DG
This gene, which is one of the largest in the human genome, encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and glycosphingolipid sugar chains. It may also be involved in the addition of a repeated disaccharide unit. Mutations in this gene cause MDC1D, a novel form of congenital muscular dystrophy with severe mental retardation and abnormal glycosylation of alpha-dystroglycan. Alternative splicing of this gene results in two transcript variants that encode the same protein.
glycosyltransferase-like protein LARGE1
, glycosyltransferase-like 1A
, acetylglucosaminyltransferase-like 1A
, acetylglucosaminyltransferase-like protein
, glycosyltransferase-like protein LARGE1-like
, glycosyltransferase-like protein LARGE2
, glycosyltransferase-like 1B
, glycosyltransferase-like 1B-B
, glycosyltransferase-like protein LARGE2-B