Leucine-Rich PPR-Motif Containing Proteine (LRPPRC)

LRPPRC encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). Zusätzlich bieten wir Ihnen LRPPRC Antikörper (37) und LRPPRC Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
LRPPRC 10128 P42704
Ratte LRPPRC LRPPRC 313867 Q5SGE0
LRPPRC 72416 Q6PB66
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$11,073.30
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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LRPPRC Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Leucine-Rich PPR-Motif Containing (LRPPRC) Interaktionspartnern

Human Leucine-Rich PPR-Motif Containing (LRPPRC) Interaktionspartner

  1. There were no significant correlations between LRP130, SIRT3, or PGC-1alpha mRNA expression in response to acute sprint-interval training. Changes in protein expression of LRP130, SIRT3, and PGC-1alpha were positively correlated at several time points with large effect sizes, which suggest that the regulation of these proteins may be coordinated in human skeletal muscle.

  2. LRPPRC displays a broad and strong RNA binding capacity in vitro in contrast to SLIRP that associates only weakly with RNA.

  3. High expression of ULK1 (zeige ULK1 Proteine) concomitant with high expression of LRPPRC may serve as useful markers for shorter biochemical progression (BCP (zeige OPN1SW Proteine))-free survival and overall survival in patients with metastatic prostate cancer (PCa (zeige FLVCR1 Proteine)) after androgen deprivation therapy (ADT).

  4. This is the first study to report hypermethylation of LRPPRC, RAB6C, and ZNF471 in squamous cell carcinoma of the tongue

  5. LRPPRC knock-down in mammalian cells leads to an imbalance between mitochondria-encoded and nuclear-encoded subunits of complex IV

  6. study identifies LRPPRC as an important disease-causing gene in an early-onset, multisystem and neurological mitochondrial disease.

  7. LRPPRC levels were reduced in muscle cells and undetectable in liver from French Canadian Leigh Syndrome patients.

  8. LRPPRC is a transcription factor related to ABCB1 expression and highlight the importance of epigenetic regulation in CML resistance.

  9. Downregulation of LRPPRC expression resulted in the reduced expression of Bcl-2 (zeige BCL2 Proteine), upregulation of Bax (zeige BAX Proteine), and cleaved caspase-9 (zeige CASP9 Proteine) and caspase-3 (zeige CASP3 Proteine). This induces apoptosis through the mitochondria-mediated pathway in PCa (zeige FLVCR1 Proteine) cells.

  10. LRPPRC functions as a checkpoint protein that prevents mitochondria from autophagy degradation and impact tumorigenesis.

Mouse (Murine) Leucine-Rich PPR-Motif Containing (LRPPRC) Interaktionspartner

  1. Data suggest NT-Pgc-1alpha (alternative splicing isoform of nuclear protein Pgc-1alpha) is located in mitochondrial matrix in brown adipocytes, specifically enriched at D-loop region of mitochondrial DNA at promoter region of Lrpprc (leucine-rich PPR-motif containing protein); expression of NT-Pgc-1alpha (rather than Pgc-1alpha) in brown adipocytes appears to induce expression of electron transport chain complex proteins.

  2. both LRPPRC and SLIRP are required for maintaining mt-mRNA steady-state levels independent of their roles in stabilizing the other partner of the LRPPRC-SLIRP complex.

  3. Ectopic expression of LRPPRC in the mouse liver completely interdicted non-alcoholic fatty liver disease, including inflammation.

  4. LRPPRC deficiency in Leigh syndrome causes an ATP synthase deficiency.

  5. LRPPRC does not directly regulate mtDNA transcription but rather acts as a post-transcriptional regulator of mammalian mtDNA expression.

  6. Heart-specific Lrpprc disruption causes mitochondrial cardiomyopathy with drastic reduction in steady-state mitochondrial mRNA levels. LRPPRC forms an RNA-dependent protein complex needed to maintain a mitochondrial pool of non-translated mRNAs.

  7. These data strongly suggest that LRPPRC is involved in the maturation of cytochrome c (zeige CYCS Proteine) oxidase (COX (zeige CPOX Proteine)), and is involved in stabilizing of mitochondrial mRNAs encoding COX (zeige CPOX Proteine) transcripts.

  8. LRP130 protein remodels mitochondria and stimulates fatty acid oxidation.

  9. Our results demonstrate that LIF (zeige LIF Proteine) signaling via the gp130/JAK (zeige JAK3 Proteine)/STAT3 (zeige STAT3 Proteine) pathway is required for the initiation of the astrogliosis-like reaction of retinal Muller cells after optic nerve injury.

  10. LRP130 may function in stabilizing minisatellite DNA sequences.

LRPPRC Protein Überblick

Protein Überblick

This gene encodes a leucine-rich protein that has multiple pentatricopeptide repeats (PPR). The precise role of this protein is unknown but studies suggest it may play a role in cytoskeletal organization, vesicular transport, or in transcriptional regulation of both nuclear and mitochondrial genes. The protein localizes primarily to mitochondria and is predicted to have an N-terminal mitochondrial targeting sequence. Mutations in this gene are associated with the French-Canadian type of Leigh syndrome.

Genbezeichner und Symbole assoziert mit LRPPRC

  • leucine rich pentatricopeptide repeat containing (LRPPRC)
  • leucine-rich pentatricopeptide repeat containing (Lrpprc)
  • leucine-rich PPR-motif containing (Lrpprc)
  • 3110001K13Rik Protein
  • C76645 Protein
  • CLONE-23970 Protein
  • Gp130 Protein
  • Lrp130 Protein
  • Lrp157 Protein
  • Lsfc Protein

Bezeichner auf Proteinebene für LRPPRC

130 kDa leucine-rich protein , LRP 130 , leucine-rich PPR motif-containing protein, mitochondrial , leucine-rich PPR-motif containing , mitochondrial leucine-rich PPR motif-containing protein , leucine rich protein 157 , leucine-rich protein 157 , rLRP157 , leucine rich protein LRP130

GENE ID SPEZIES
10128 Homo sapiens
313867 Rattus norvegicus
72416 Mus musculus
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