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KLF8 encodes a protein which is a member of the Sp/KLF family of transcription factors. Zusätzlich bieten wir Ihnen KLF8 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 54 products:
Cow (Bovine) Polyclonal KLF8 Primary Antibody für IHC, WB - ABIN2777342
Lossi, Laugier-Anfossi, Depetris, Gecz, Gedeon, Kooy, Schwartz, Mattei, Croquette, Villard: Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation. in Journal of medical genetics 2002
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Human Polyclonal KLF8 Primary Antibody für ELISA, WB - ABIN249552
Ding, Grammer, Nelson, Guan, Stewart, Gladson: p27Kip1 and cyclin D1 are necessary for focal adhesion kinase regulation of cell cycle progression in glioblastoma cells propagated in vitro and in vivo in the scid mouse brain. in The Journal of biological chemistry 2005
Show all 2 Pubmed References
Human Polyclonal KLF8 Primary Antibody für IF, WB - ABIN524708
Schnell, Romagna, Jaehnert, Albrecht, Eigenbrod, Juerchott, Kretzschmar, Tonn, Schichor: Krüppel-like factor 8 (KLF8) is expressed in gliomas of different WHO grades and is essential for tumor cell proliferation. in PLoS ONE 2012
Results demonstrate a novel role of Klf8, achieved via modulation of p53 (zeige TP53 Antikörper) and met expression, in the maintenance neuronal progenitors and development of Purkinje cells and the proliferation of granule cells in the cerebella of zebrafish embryos
expression of miR (zeige MLXIP Antikörper)-1236-3p was lower in lung adenocarcinoma tissues than that in adjacent normal tissue; in A549 cell line, miR (zeige MLXIP Antikörper)-1236-3p decreased ability of cell invasion and migration; furthermore, KLF8 is targeted by miR (zeige MLXIP Antikörper)-1236-3p, and expression of miR (zeige MLXIP Antikörper)-1236-3p is negatively correlated with KLF8; additionally, miR (zeige MLXIP Antikörper)-1236-3p suppressed the expression of KLF8 and EMT (zeige ITK Antikörper) (epithelial mesenchymal transition)-related genes
Overexpression of KLF8 may contribute to the progression of pancreatic cancer, and downregulation of KLF8 expression by lentivirus-delivered shRNA is a novel therapeutic approach for PC.
KLF8 plays a crucial role in proliferation and migration of bladder cancer cells
KLF8-induced FHL2 (zeige FHL2 Antikörper) activation is a novel and critical signaling mechanism underlying human colorectal cancer invasion and metastasis.
KLF8 and miR141/EGFR (zeige EGFR Antikörper) have roles in signaling pathway potentially crucial for breast cancer malignancy
KLF8 suppression induced cell differentiation and inhibited tumorigenesis in colorectal cancer
MiR (zeige MLXIP Antikörper)-135a inhibits migration and invasion and regulates epithelial-mesenchymal transition-related marker genes by targeting KLF8 in lung cancer cells.
KLF8 is a novel epithelial to mesenchymal transition regulating transcription factor that involved in the progression of gastric cancer.
In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC (zeige FAM126A Antikörper), summarize key pathways, and propose areas for further investigation
A novel KLF8 to EPSTI1 to VCP (zeige vcp Antikörper) to NF-kappaB (zeige NFKB1 Antikörper) signaling mechanism potentially critical for breast cancer invasion and metastasis.
Klf8 is highly expressed in various regions of the mouse brain and in particular in the neurons, where it was localized in the cell nuclei.
KLF3 and KLF8 have overlapping roles in vivo and participate in the silencing of embryonic globin expression during development.
KLF8 is a key component of the transcription factor network that controls terminal differentiation during adipogenesis.
PARP-1 (zeige PARP1 Antikörper) as a novel KLF8-binding and -regulating protein and provided new insights into the mechanisms underlying the regulation of KLF8 nuclear localization, stability, and functions.
These results identified the KLF8 activation domain located between residues 101-260 where the well-conserved Q118 and Q248 are essential for recruiting p300 (zeige NOTCH1 Antikörper) and PCAF (zeige KAT2B Antikörper) to activate target gene transcription.
sumoylation of KLF8 negatively regulates its transcriptional activity and cellular functions
Klf8 is repressed by Klf3 (zeige KLF3 Antikörper) and activated by Klf1 (zeige KLF1 Antikörper) in vivo.
KLF8 has two N terminal regulatory regions, one surrounding S165 and K171 and the other being two tandem ZFs, which are critical for the regulation of KLF8 nuclear localization and its cellular functions
results demonstrate that KLF8 can participate in regulating expression of alternate forms of HuR (zeige ELAVL1 Antikörper) mRNA along with NF-kappaB (zeige NFKB1 Antikörper) and other factors, depending on cellular contexts
This gene encodes a protein which is a member of the Sp/KLF family of transcription factors. Members of this family contain a C-terminal DNA-binding domain with three Kruppel-like zinc fingers. The encoded protein is thought to play an important role in the regulation of epithelial to mesenchymal transition, a process which occurs normally during development but also during metastasis. A pseudogene has been identified on chromosome 16. Alternative splicing results in multiple transcript variants.
Krueppel-like factor 8
, kruppel-like factor 8
, Kruppel-like factor 8
, basic krueppel-like factor 3
, basic kruppel-like factor 3
, zinc finger protein 741
, Kruppel-like factor 8, pseudogene 1