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The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]\; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010].. Zusätzlich bieten wir Ihnen KHSRP Antikörper (69) und KHSRP Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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TGF-beta (zeige TGFB1 ELISA Kits)-induced KHSRP silencing is central in a pathway leading to gene-expression.
mechanistic evidence that KSRP promotes the down-regulation of Spry4 (zeige SPRY4 ELISA Kits) by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.
The interaction between the KLHL12 (zeige KLHL12 ELISA Kits) and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.
The miRNA biogenesis factors, DDX17 (zeige DDX17 ELISA Kits) and KHSRP, regulate the protein level of Ago2 (zeige EIF2C2 ELISA Kits) in human cells.
Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis.
High FBP2 expression is associated with doxorubicin resistance in breast cancer .
Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells
The expression of KSRP in liver epithelial cells controlled by mir (zeige MLXIP ELISA Kits)-27b.
Khsrp as a highly regulated RBP (zeige RBP4 ELISA Kits) in response to genotoxic stress.
Functional analysis of selected regulated proteins revealed that knockdown of HNRPD (zeige HNRNPD ELISA Kits), PHB2 (zeige PHB2 ELISA Kits) and UB2V2 (zeige UBE2V2 ELISA Kits) can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication.
IFN-gamma (zeige IFNG ELISA Kits) production was increased in spleen cells of KSRP(-/-) mice.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1 (zeige HNRNPA1 ELISA Kits).
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 (zeige PER2 ELISA Kits) expression
KSRP modulation of GAP-43 (zeige GAP43 ELISA Kits) mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR (zeige MLXIP ELISA Kits)-150 expression.
This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR (zeige MLXIP ELISA Kits)-145 expression.
KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation.
Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases.
We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU (zeige CGA ELISA Kits) is increased by let7b/c through downregulation of KSRP
data suggest that miR (zeige MLXIP ELISA Kits)-27b targets KSRP and modulates iNOS (zeige NOS2 ELISA Kits) mRNA stability following C. parvum infection, a process that may be relevant to the regulation of epithelial anti-microbial defense in general
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997
KH-type splicing regulatory protein
, KH-type splicing regulatory protein (FUSE binding protein 2)
, FUSE binding protein 2
, far upstream element-binding protein 2
, FUSE-binding protein 2
, KH type-splicing regulatory protein
, MAP2 RNA trans-acting protein 1
, MAP2 RNA trans-acting protein MARTA1
, zipcode-binding protein 2