Isocitrate Dehydrogenase 1 (NADP+), Soluble Proteine (IDH1)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH1 Antikörper (210) und IDH1 Kits (24) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$678.00
Details
Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$704.00
Details
Escherichia coli (E. coli) Human His tag Human IDH1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$275.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$340.00
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,147.83
Details
Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$736.00
Details
Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details

IDH1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
,
Mouse (Murine) ,
,
Rat (Rattus) ,

Weitere Proteine zu Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartnern

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5'-diphosphate-ribose) polymerase inhibitors

  2. To confirm this result, we analyzed survival data from 142 LGGs from TCGA with IDH1/IDH2 (zeige IDH2 Proteine) mutations and no 1p19q codeletion. Despite the high rate of censured data, we found that CNLOH 17p, including the TP53 (zeige TP53 Proteine) locus, was associated with better outcome (OR = 0.27; p = .026)

  3. Results suggest that to better treat gliomas, isocitrate dehydrogenase (NADP(+)) 1 (IDH-1) mutation status should be included when determining WHO2007 grade in glioma patients.

  4. The found of this study suggest that IDH1 mutation status had greater impact than histological and other genomic features on miRNA expression patterns.

  5. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1/IDH2 (zeige IDH2 Proteine), ATRX (zeige ATRX Proteine), and 1p/19q results.

  6. Study indicates IDH1 mutation status was not predictive of 6-month progression free survival or radiographic response in recurrent glioblastoma trials for this data set.

  7. Study demonstrates that patients with IDH1 mutant tumor have significantly higher brain network global efficiency and degree compared to patients with wild type tumor, despite having larger tumor volumes.

  8. In this review, we focus on three key areas in acute myeloid leukemia (zeige BCL11A Proteine) (AML (zeige RUNX1 Proteine)) developmental therapeutics: FLT3 (zeige FLT3 Proteine) inhibitors, IDH(IDH1 and IDH2 (zeige IDH2 Proteine) ) inhibitors, and drugs that may be particularly beneficial in secondary AML (zeige RUNX1 Proteine)

  9. The role of mutant IDH1 and IDH2 (zeige IDH2 Proteine) inhibitors in the treatment of acute myeloid leukemia (zeige BCL11A Proteine).

  10. Data suggest that identification of IDH1-R132H and ATRX (zeige ATRX Proteine) loss status in the primary-recurrent gliomas may aid in treatment strategy selection, therapeutic trial design, and clinical prognosis evaluation.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  2. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  3. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  4. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (zeige ACO1 Proteine), enzymes involved in the TCA cycle, were elevated.

  5. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  6. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  7. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  8. MiR (zeige MLXIP Proteine)-181a regulates lipid metabolism via IDH1

  9. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  10. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)

  3. These results suggest that IDPm (zeige IDH2 Proteine) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Proteine) activity.

IDH1 Protein Überblick

Protein Überblick

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Genbezeichner und Symbole assoziert mit IDH1

  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (IDH1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1)
  • isocitrate dehydrogenase 1 (NADP+) L homeolog (idh1.L)
  • isocitrate dehydrogenase (NADP(+)) 1, cytosolic (Idh1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1)
  • parathyroid hormone 2 receptor (PTH2R)
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2)
  • AI314845 Protein
  • AI788952 Protein
  • cb876 Protein
  • E030024J03Rik Protein
  • fm90e09 Protein
  • Id-1 Protein
  • IDCD Protein
  • IDH Protein
  • Idh-1 Protein
  • IDP Protein
  • Idpc Protein
  • im:7143416 Protein
  • NADP-CICDH Protein
  • PICD Protein
  • wu:fm90e09 Protein

Bezeichner auf Proteinebene für IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPEZIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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