Isocitrate Dehydrogenase 1 (NADP+), Soluble Proteine (IDH1)

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH1 Antikörper (207) und IDH1 Kits (20) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
IDH1 3417 O75874
IDH1 15926 O88844
IDH1 24479 P41562
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Top IDH1 Proteine auf antikoerper-online.de

Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
645,71 €
Details
HOST_Escherichia coli (E. coli) Maus His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
670,48 €
Details
HOST_Escherichia coli (E. coli) Human His tag Human IDH1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
314,29 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
448,15 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.997,93 €
Details
HOST_Escherichia coli (E. coli) Ratte His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
700,95 €
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
287,50 €
Details

IDH1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
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Mouse (Murine) ,
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Rat (Rattus) ,

Weitere Proteine zu Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartnern

Human Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. IDH mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm (zeige IDH2 Proteine) ICC cells are hypersensitive to dasatinib and critically dependent on SRC (zeige SRC Proteine) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.

  2. Mutations in the IDH1 and IDH2 (zeige IDH2 Proteine) genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]

  3. Profiled 4400 freshly isolated single cells from isocitrate IDH1-mutant oligodendrogliomas and 7500 single cells from IDH1-mutant astrocytomas by RNA-seq. Found that irrespective of their histologic subclassification into astrocytic or oligodendroglial tumors, all IDH1 mutant gliomas share a similar cellular architecture that is distinct from IDH1 wild-type gliomas.

  4. IDH1 mutation is associated with high-grade gliomas.

  5. six out of six recurrent and IDH1 mutated grade III tumors also showed XAF1 (zeige XAF1 Proteine) promoter methylation

  6. IDH1 R132C mutation is associated with clear cell hepatocellular carcinoma.

  7. Identification of IDH1 or IDH2 (zeige IDH2 Proteine) mutations supports the diagnosis of dedifferentiated chondrosarcoma rather than undifferentiated pleomorphic sarcoma of bone.

  8. The data of this study suggested that mutant IDH1 has potent antithrombotic activity within gliomas and throughout the peripheral circulation.

  9. This retrospective analysis suggested that the presence of an IDH1 (R132H) mutation, frontal tumor location, and WHO grade of the initial tumor are associated with OS after progression to secondary glioblastoma.

  10. Expression of mutant IDH1 suppresses the accumulation of T cells in glioma tumor sites.

Mouse (Murine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. IDH1 mutations caused down-regulation of leukocyte chemotaxis, resulting in repression of the tumor-associated immune system.

  2. Idh1(R132H) mutation in the major adult neurogenic stem cell niche causes a phenotype resembling gliomagenesis

  3. Mutant IDH1 downregulates the DNA damage (DD) sensor ATM by altering histone methylation, leading to impaired DNA repair, increased sensitivity to DD, and reduced HSC self-renewal, independent of TET2.

  4. Using whole RNA sequencing of bone marrow cells in iron-overloaded mice, it was observed that Idh1 and Aco1 (zeige ACO1 Proteine), enzymes involved in the TCA cycle, were elevated.

  5. data suggest that mutant IDH1 contributes to malignancy in the T-cell lineage and may alter the metabolic profile of malignant T cells

  6. The results suggest that Idh1 has a physiological function in protecting cells from oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

  7. These results support the translational potential of immunotherapeutic targeting of gliomas carrying IDH1 mutations R132H.

  8. MiR (zeige MLXIP Proteine)-181a regulates lipid metabolism via IDH1

  9. revealed a role for IDH1 in the synthesis/turnover of phospholipids in developing astrocytes and highlight the lipid alterations resulting from the loss of wild-type IDH1 activity.

  10. these data show that mutant IDH or d-2HG causes persistence of chondrocytes, giving rise to rests of growth-plate cells that persist in the bone as enchondromas.

Cow (Bovine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. Data suggest that the expression of cytosolic NADP+-dependent isocitrate dehydrogenase in bovine mammary epithelium is modulated by regulators of differentiation including extracellular matrix and lactogenic hormones as well as metabolic effectors.

Pig (Porcine) Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Proteine)

  3. These results suggest that IDPm (zeige IDH2 Proteine) plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Proteine) activity.

IDH1 Protein Überblick

Protein Überblick

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production.

Genbezeichner und Symbole assoziert mit IDH1

  • isocitrate dehydrogenase 1 (NADP+), soluble (IDH1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (Idh1)
  • isocitrate dehydrogenase 1 (NADP+), soluble (idh1)
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (IDH2)
  • AI314845 Protein
  • AI788952 Protein
  • cb876 Protein
  • E030024J03Rik Protein
  • fm90e09 Protein
  • Id-1 Protein
  • IDCD Protein
  • IDH Protein
  • Idh-1 Protein
  • IDP Protein
  • Idpc Protein
  • im:7143416 Protein
  • NADP-CICDH Protein
  • PICD Protein
  • wu:fm90e09 Protein

Bezeichner auf Proteinebene für IDH1

isocitrate dehydrogenase 1 (NADP+), soluble , isocitrate dehydrogenase [NADP] cytoplasmic-like , NADP(+)-specific ICDH , NADP-dependent isocitrate dehydrogenase, cytosolic , NADP-dependent isocitrate dehydrogenase, peroxisomal , isocitrate dehydrogenase [NADP] cytoplasmic , oxalosuccinate decarboxylase , IDH , IDP , cytosolic NADP-isocitrate dehydrogenase , isocitrate dehydrogenase 1 , Isocitrate dehydrogenase 1, soluble , ICD-M , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase [NADP], mitochondrial

GENE ID SPEZIES
478889 Canis lupus familiaris
751618 Felis catus
100414768 Callithrix jacchus
3417 Homo sapiens
15926 Mus musculus
494713 Xenopus laevis
100328559 Oryctolagus cuniculus
24479 Rattus norvegicus
281235 Bos taurus
100006589 Danio rerio
100170146 Sus scrofa
443257 Ovis aries
397603 Sus scrofa
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