Hypoxia Inducible Factor 3, alpha Subunit Proteine (HIF3A)

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Zusätzlich bieten wir Ihnen HIF3A Antikörper (97) und HIF3A Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
HIF3A 53417 Q0VBL6
HIF3A 64345 Q9JHS2
HIF3A 64344 Q9Y2N7
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.734,76 €
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HIF3A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human ,
,

Weitere Proteine zu Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartnern

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

Zebrafish Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

  1. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (zeige HIF1A Proteine)

  2. mRNA of HIF-2alpha (zeige EPAS1 Proteine) and Ets-1 (zeige ETS1 Proteine) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (zeige CDH5 Proteine) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (zeige CDH5 Proteine) gene.

  3. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  4. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (zeige HIF1A Proteine) and HIF-3alpha expression.

  5. alternative splicing and expression of IPAS is induced by hypoxia.

  6. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  7. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (zeige ARNT Proteine).

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaktionspartner

  1. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase (zeige ALT Proteine) among obese children.

  2. TIMP2 (zeige TIMP2 Proteine) suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha (zeige HIF1A Proteine), microRNA-210 (miR (zeige MLXIP Proteine)-210), and HIF-3alpha.

  3. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

  4. DNA methylation (zeige HELLS Proteine) in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN (zeige FASN Proteine) is poorly correlated across tissues, but the DNA methylation (zeige HELLS Proteine) in adipose tissue but not blood is highly associated with BMI

  5. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha (zeige HIF1A Proteine) or Bcl-xL (zeige BCL2L1 Proteine), binding proteins of IPAS in the nucleus and mitochondria, respectively.

  6. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin (zeige INS Proteine) sensitivity.

  7. Parkin (zeige PARK2 Proteine) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  8. This provides a compelling model for how hypoxia-induced miR (zeige MLXIP Proteine)-429 regulates the switch between HIF-1 (zeige HIF1A Proteine) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (zeige HIF1A Proteine) levels while simultaneously slowing the progression of HIF3A expression until the miR (zeige MLXIP Proteine)-429 levels drop below normoxic levels.

  9. The association between increased DNA methylation (zeige HELLS Proteine) at HIF3A and increased adiposity is present in neonates.

  10. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT

HIF3A Protein Überblick

Protein Überblick

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit HIF3A

  • hypoxia inducible factor 3, alpha subunit (HIF3A)
  • hypoxia-inducible factor 1, alpha subunit, like (hif1al)
  • hypoxia inducible factor 3, alpha subunit (Hif3a)
  • bHLHe17 Protein
  • HIF-3A Protein
  • HIF3A Protein
  • IPAS Protein
  • Mop7 Protein
  • NEPAS Protein
  • PASD7 Protein
  • zgc:63965 Protein

Bezeichner auf Proteinebene für HIF3A

hypoxia inducible factor 3, alpha subunit , Hif3a , Hif3a-like , hypoxia-inducible factor 3 alpha subunit , hypoxia-inducible factor 3-alpha , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like , HIF-3-alpha , HIF3-alpha , HIF3-alpha-1 , basic-helix-loop-helix-PAS protein MOP7 , hypoxia inducible factor three alpha , inhibitory PAS domain protein , member of PAS protein 7 , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , PAS domain-containing protein 7 , class E basic helix-loop-helix protein 17

GENE ID SPEZIES
281815 Bos taurus
393376 Danio rerio
456149 Pan troglodytes
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
53417 Mus musculus
64345 Rattus norvegicus
64344 Homo sapiens
476429 Canis lupus familiaris
100621574 Sus scrofa
507699 Bos taurus
100071095 Equus caballus
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