anti-Hemoglobin, gamma A (HBG1) Antikörper

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Zusätzlich bieten wir Ihnen HBG1 Proteine (12) und HBG1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
HBG1 94164  
HBG1 3047 P69891
HBG1    
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Top anti-HBG1 Antikörper auf antikoerper-online.de

Showing 10 out of 39 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB HBG1 Antibody (Center) (ABIN657619) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the HBG1 antibody detected the HBG1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (33.04 KDa) . 50 μL Anmelden zum Anzeigen 7 bis 8 Tage
241,60 €
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Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged HBG1 is 3 ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
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Human Kaninchen Unkonjugiert WB Western blot analysis of HBG1 using rabbit polyclonal HBG1 Antibody using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HBG1 gene. Western blot analysis in K562 cell line lysates (35ug/lane). 400 μL Anmelden zum Anzeigen 6 bis 8 Tage
538,22 €
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Human Maus Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
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Human Kaninchen HRP ELISA, IHC (p)   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
687,93 €
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Human Kaninchen Biotin ELISA, IHC (p)   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
687,93 €
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Human Kaninchen FITC ELISA, IHC (p)   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
687,93 €
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Human Kaninchen Unkonjugiert WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
941,11 €
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Human Kaninchen Biotin WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
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HBG1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Rat (Rattus)


Human , ,
,
,
, , , , ,
Mouse (Murine)


Am meisten referenzierte anti-HBG1 Antikörper

  1. Human Polyclonal HBG1 Primary Antibody für WB - ABIN657619 : Zhou, Liu, Sun, Pawlik, Townes: KLF1 regulates BCL11A expression and gamma- to beta-globin gene switching. in Nature genetics 2010 (PubMed)

  2. Human Polyclonal HBG1 Primary Antibody für ELISA, WB - ABIN561232 : Lee, Kim, Byrnes, de Vasconcellos, Noh, Rabel, Meier, Miller: A synthetic model of human beta-thalassemia erythropoiesis using CD34+ cells from healthy adult donors. in PLoS ONE 2013 (PubMed)

Weitere Antikörper gegen HBG1 Interaktionspartner

Human Hemoglobin, gamma A (HBG1) Interaktionspartner

  1. Introduction of the British HPFH mutation into the fetal globin promoter in a human cell model causes elevated fetal globin expression. The British HPFH mutation creates a de novo binding site both in vitro and in vivo for the potent erythroid activator KLF1 (zeige KLF1 Antikörper).

  2. A Ly1 antibody reactive (LYAR)-binding motif disruptive regulatory single-nucleotide polymorphisms rs368698783 (G/A) from LD block 5 in the proximal promoter of hemoglobin subunit gamma 1 (HBG1) was found to be a significant predictor for beta-thalassemia clinical severity.

  3. Study found a novel polymorphism of the A-gamma-globin gene in four families with b0-thalassemia and high levels of HbF expression. Additionally, evidence suggesting that the Ac-globin gene +25(G-A) polymorphism decreases the efficiency of the interaction between this sequence and specific DNA binding protein (zeige UBE2V1 Antikörper) complexes.

  4. These data confirm the regulatory role of the HBG1: g.-225_-222 region that exerts its effect under conditions of erythropoietic stress characteristic for beta-thal patients.

  5. results suggest that KLF1 directly regulates the beta-globin gene, but probably has less direct impact on expression of the gamma-globin gene in fetal erythroblasts

  6. Data show that the ancestral allele C at rs2855126, located upstream of gamma-globin (HBG1) is associated with increased serum uric acid levels.

  7. analysis of a point mutation that increases fetal globin expression through de novo recruitment of the activator TAL1 to promote chromatin looping of distal enhancers to the modified gamma-globin promoter

  8. a successful induction of gamma-globin includes a reduction in BCL11A (zeige BCL11A Antikörper), KLF1 (zeige KLF1 Antikörper) and TAL1 (zeige TAL1 Antikörper) expression.

  9. This report we discusses the molecular characteristics and diagnostic criteria of a new (A)gamma chain variant that was detected during newborn screening and named Hb F-Sykesville MD [(A)gamma113(G15 (zeige RBM5 Antikörper))Val --> Ile; HBG1: c.340G>A].

  10. Results indicate that compound II induces the gamma globin gene in hydroxyurea (HU)-resistant primary adult erythroid cells and suggest potenetial therapy for sickle cell disease (SCD (zeige SCD Antikörper)) and severe beta-thalassemias.

HBG1 Antigen-Profil

Protein Überblick

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'.

Genbezeichner und Symbole assoziert mit HBG1

  • hemoglobin subunit gamma-1-like (LOC100438895) Antikörper
  • hemoglobin, gamma A (Hbg1) Antikörper
  • hemoglobin, gamma A (HBG1) Antikörper
  • hemoglobin, gamma G (HBG2) Antikörper
  • Hbb-y Antikörper
  • Hbe1 Antikörper
  • HBG1 Antikörper
  • HBG2 Antikörper
  • HBGA Antikörper
  • HBGR Antikörper
  • HSGGL1 Antikörper

Bezeichner auf Proteinebene für HBG1

epsilon 3 globin , hemoglobin Y beta-like embryonic chain , hemoglobin Y, beta-like embryonic chain , hemoglobin, epsilon 1 , hemoglobin, gamma A , A-gamma globin , gamma A hemoglobin , gamma globin , gamma-1-globin , hb F Agamma , hemoglobin gamma-1 chain , hemoglobin gamma-a chain , hemoglobin subunit gamma-1 , hemoglobin, gamma, regulator of , epsilon-globin , hemoglobin, gamma G

GENE ID SPEZIES
100438895 Pongo abelii
94164 Rattus norvegicus
100137314 Papio anubis
3047 Homo sapiens
450979 Pan troglodytes
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