HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) ELISA Kits

HUWE1 encodes a member of the HECT E3 ubiquitin ligase family. Zusätzlich bieten wir Ihnen HUWE1 Antikörper (69) und HUWE1 Proteine (2) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
HUWE1 10075 Q7Z6Z7
HUWE1 59026 Q7TMY8
HUWE1 501546  
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Top HUWE1 ELISA Kits auf antikoerper-online.de

Showing 10 out of 25 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus 11 pg/mL 43.75-2800 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
772,39 €
Details
Human 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
673,47 €
Details
Ratte 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
673,47 €
Details
Affe 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
673,47 €
Details
Maus 0.1 ng/mL 1.0-25 ng/mL   96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
673,47 €
Details
Human 0.067 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
653,71 €
Details
Schaf
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
673,47 €
Details
Maus
0.312-20 ng/mL   96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
653,71 €
Details
Ratte
0.78-50 ng/mL   96 Tests Anmelden zum Anzeigen 6 bis 8 Tage
653,71 €
Details
Ziege
  96 Tests Anmelden zum Anzeigen 13 bis 17 Tage
673,47 €
Details

Weitere ELISA Kits für HUWE1 Interaktionspartner

Mouse (Murine) HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Interaktionspartner

  1. Mule also regulates protein levels of the receptor tyrosine kinase (zeige ERBB3 ELISA Kits) EphB3 (zeige EPHB3 ELISA Kits) by targeting it for proteasomal and lysosomal degradation.

  2. this study shows that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain-containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence.

  3. TNF (zeige TNF ELISA Kits) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (zeige SYK ELISA Kits) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (zeige TNF ELISA Kits)-induced JNK (zeige MAPK8 ELISA Kits) activation and cell death.

  4. expression level of miR (zeige MLXIP ELISA Kits)-98, which can regulate Caspase-3 (zeige CASP3 ELISA Kits), was significantly decreased. Huwe1, the host gene of miR (zeige MLXIP ELISA Kits)-98, was positively associated with miR (zeige MLXIP ELISA Kits)-98 expression after Silica NP exposure

  5. Thus, modulating the levels of both Huwe1 and USP10 (zeige USP10 ELISA Kits) appears to fine-tune the requisite degradation of TBP (zeige TBP ELISA Kits) during myogenesis.

  6. Results show that ARF-BP1 was expressed at high levels in B-cell lymphoma cell lines and by regulating MYC and p53 transcriptional activity, ARF-BP1 is a critical determinant of the proliferation of B cell lymphomas.

  7. The dynamic balance between MYC and p53 required for normal B cell maturation and function is finely tuned and critically dependent on the activities of ARF-BP1.

  8. data demonstrate in vivo that Mule suppresses Ras-mediated tumorigenesis by preventing an accumulation of c-Myc (zeige MYC ELISA Kits)/Miz1 (zeige PIAS2 ELISA Kits) complexes that mediates p21 and p15 (zeige CDKN2B ELISA Kits) down-regulation

  9. an important role of ARF-BP1 in maintaining beta-cell homeostasis in aging mice and reveal that the stability of p53 is critically regulated by ARF-BP1 in vivo.

  10. Mule regulates the ATM (zeige ATM ELISA Kits)-p53 (zeige TP53 ELISA Kits) axis to maintain B cell homeostasis under both steady-state and stress conditions.

Human HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1) Interaktionspartner

  1. HUWE1 is essential for genomic stability, by promoting replication of damaged DNA We show that HUWE1-knockout cells are unable to mitigate replication stress, resulting in replication defects and DNA breakage.

  2. N-myc expression was upregulated in response to stress or following loss of Huwe1, which led to increased proliferation and stem-cell exhaustion.

  3. The interaction with Huwe1 and polyubiquitylation were blocked by disruption of casein kinase 1 (CK1 (zeige CSNK1A1 ELISA Kits)) activity, and mass spectrometry and mutational analysis identified serine 334 as an important phosphorylation site for Atoh1 (zeige ATOH1 ELISA Kits) ubiquitylation and subsequent degradation.

  4. Elevated HECTH9 protein expression is associated with pathogenesis of hepatocellular carcinoma.

  5. Mechanistic investigation revealed that HUWE1 can regulate p53 protein level through its stabilization. HUWE1 functions as a tumour suppressor in thyroid cancer progression, which may represent a novel therapeutic target for prevention or intervention of thyroid cancer.

  6. We identified a HUWE1 mutation in an affected male with Juberg-Marsidi and Brooks syndromes from the original family reported by Juberg and Marsidi; it is evident the syndrome does not result from a mutation in ATRX as reported in the literature. Additionally, the data indicated that Juberg-Marsidi syndrome and Brooks syndromes are allelic having the same HUWE1 mutation.

  7. Results reveal a pathway controlled by ATM, SIRT6, and SNF2H to block HUWE1, which stabilizes H2AX and induces its incorporation into chromatin only when cells are damaged.

  8. miR-542-5p plays a critical role in the proliferation of osteosarcoma and targets HUWE1.

  9. TNF (zeige TNF ELISA Kits) activates Mule by inducing the dissociation of Mule from its inhibitor ARF. Inhibition of Mule phosphorylation by silencing Syk (zeige SYK ELISA Kits) prevents this, thereby inhibiting Mule E3 ligase activity and TNF (zeige TNF ELISA Kits)-induced JNK (zeige MAPK8 ELISA Kits) activation and cell death.

  10. HUWE1 and NEDD4-1 (zeige NEDD4 ELISA Kits) are two E3 ligases that are fundamental enzymes in the post-translational regulation of ABCG1 (zeige ABCG1 ELISA Kits) and ABCG4 (zeige ABCG4 ELISA Kits) protein levels and cellular cholesterol export activity

HUWE1 Antigen-Profil

Beschreibung des Gens

This gene encodes a member of the HECT E3 ubiquitin ligase family. The HECT domain lies in the C-terminus and contains the active-site cysteine which forms an intermediate ubiquitin-thioester bond. E3 family members are divided into three subfamilies based on their protein-protein interaction domains\; this gene encodes a member of the SI(ngle)-HECT E3 subfamily. In lung, breast, and colorectal carcinomas, this gene is highly expressed. Mutations in this gene has been found in 3 unrelated families with X-linked syndromic mental retardation, Turner type.

Genbezeichner und Symbole assoziert mit HUWE1

  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (HUWE1) Antikörper
  • HECT, UBA and WWE domain containing 1 (Huwe1) Antikörper
  • HECT, UBA and WWE domain containing 1 (HUWE1) Antikörper
  • HECT, UBA and WWE domain containing 1 (huwe1) Antikörper
  • HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase (Huwe1) Antikörper
  • 5430439H10Rik Antikörper
  • arf-bp1 Antikörper
  • AU041296 Antikörper
  • C80292 Antikörper
  • C430014N20Rik Antikörper
  • Gm1718 Antikörper
  • hecth9 Antikörper
  • hspc272 Antikörper
  • Huwe1 Antikörper
  • ib772 Antikörper
  • lasu1 Antikörper
  • mule Antikörper
  • si:dkey-242a8.2 Antikörper
  • URE-B1 Antikörper
  • ureb1 Antikörper

Bezeichner auf Proteinebene für HUWE1

ARF-binding protein 1 , BJ-HCC-24 tumor antigen , E3 ubiquitin-protein ligase HUWE1 , HECT domain protein LASU1 , Mcl-1 ubiquitin ligase E3 , URE-binding protein 1 , homologous to E6AP carboxyl terminus homologous protein 9 , large structure of UREB1 , upstream regulatory element-binding protein 1 , E3Histone , HECT, UBA and WWE domain-containing protein 1 , Mcl-1 ubiquitin ligase , URE-B1 , upstream regulatory element binding protein 1 , HECT, UBA and WWE domain containing 1 , rp3-339a18.4 , e3 ubiquitin-protein ligase HUWE1-like

GENE ID SPEZIES
10075 Homo sapiens
59026 Mus musculus
465650 Pan troglodytes
480931 Canis lupus familiaris
511826 Bos taurus
559439 Danio rerio
700136 Macaca mulatta
100060375 Equus caballus
100123214 Nasonia vitripennis
100126217 Xenopus (Silurana) tropicalis
100380641 Salmo salar
100483129 Ailuropoda melanoleuca
100563451 Anolis carolinensis
501546 Rattus norvegicus
Ausgewählte Anbieter für HUWE1 (HUWE1) ELISA Kits
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