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GCA product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. Zusätzlich bieten wir Ihnen Grancalcin Antikörper (27) und Grancalcin Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Homozygous Gca (zeige GUCA1A Proteine) mutants appeared healthy and reproduced normally. Leukocyte recruitment into the peritoneal cavity upon induction of inflammation was not significantly affected by the absence of grancalcin.
findings suggest that grancalcin plays a key role in leukocyte-specific functions that are responsible for host defense
Adhesion to fibronectin (zeige FN1 Proteine) of grancalcin-deficient neutrophils was decreased by 60% compared to control cells.
Results indicate that heterodimerization of GCA (zeige NPR1 Proteine) and TLR9 (zeige TLR9 Proteine) is important for TLR9 (zeige TLR9 Proteine)-mediated downstream signaling and might serve to fine tune processes against viral infection.
GCA (zeige NPR1 Proteine) interacts with SRI (zeige SRI Proteine) in vivo and in vitro.
The reported type 1 diabetes association is from a linkage disequilibrium region including three candidate genes, FAP, IFIH1 (zeige IFIH1 Proteine) and GCA (zeige NPR1 Proteine).
IFIH1 (zeige IFIH1 Proteine) interferon (zeige IFNA Proteine) induced helicase, GCA grancalcin or the potassium channel (zeige KCNAB2 Proteine) KCNH7 (zeige KCNH7 Proteine) - are potential candidates implicated in the pathogenesis of multiple sclerosis.
IFIH1 (zeige IFIH1 Proteine)-GCA (zeige NPR1 Proteine)-KCNH7 (zeige KCNH7 Proteine) locus is not associated with genetic susceptibility to multiple sclerosis in French patients
This gene product, grancalcin, is a calcium-binding protein abundant in neutrophils and macrophages. It belongs to the penta-EF-hand subfamily of proteins which includes sorcin, calpain, and ALG-2. Grancalcin localization is dependent upon calcium and magnesium. In the absence of divalent cation, grancalcin localizes to the cytosolic fraction\; with magnesium alone, it partitions with the granule fraction\; and in the presence of magnesium and calcium, it associates with both the granule and membrane fractions, suggesting a role for grancalcin in granule-membrane fusion and degranulation.
, grancalcin, EF-hand calcium-binding protein
, grancalcin, penta-EF-hand protein