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Glutamate Decarboxylase 1 (Brain, 67kDa) Proteine (GAD1)

GAD1 encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. Zusätzlich bieten wir Ihnen GAD Antikörper (175) und GAD Kits (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GAD1 14415 P48318
GAD1 24379 P18088
GAD1 2571 Q99259
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Showing 9 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_HEK-293 Cells Human His tag 10 μg Anmelden zum Anzeigen 6 bis 8 Tage
337,56 €
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HOST_Baculovirus infected Insect Cells Human His tag 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.530,48 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
139,69 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 6 bis 8 Tage
403,06 €
Details

GAD1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human , , , ,
, ,

Weitere Proteine zu Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartnern

Mouse (Murine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. This study demonstrated that Alterations in hypoglossal motor neurons due to GAD67 deficiency in mice.

  2. Treadmill running prevented partial sciatic nerve ligation-induced reductions in GAD65 (zeige GAD2 Proteine)/67 production, and, thus, GABA levels may be retained in interneurons and neuropils in the superficial dorsal horn.

  3. Effects of Ubiquitin C-Terminal Hydrolase (zeige UCHL1 Proteine) L1 (UCH-L1 (zeige UCHL1 Proteine)) inhibition on sperm incorporation and cortical tension in mouse eggs.

  4. Gad1 knockdown mice have pronounced sensorimotor gating deficits, increased novelty-seeking and reduced fear extinction

  5. The neuronal marker UCH-L1 (zeige UCHL1 Proteine) is induced in, and specifically augments the oncogene (zeige RAB1A Proteine)-induced transformation of, germinal center B cells.

  6. Glutamate decarboxylase (zeige GLUL Proteine) expression may be a reliable proxy of altered GABAergic transmission.

  7. Activity deprivation due to TTX preferentially down-regulated GAD67. BDNF (zeige BDNF Proteine)-induced increase in the GAD67 protein was markedly lower than that of GAD65 (zeige GAD2 Proteine), indicating that BDNF (zeige BDNF Proteine) differentially regulates activity-dependent gene expression of the 2 isoforms.

  8. The results of this study indicated that the mice heterozygous for GAD67 deficiency primarily in PV neurons share several neurochemical and behavioral abnormalities with schizophrenia.

  9. Data demonstrate that GAD67 levels directly influence synaptic inhibition.

  10. The GAD65 (zeige GAD2 Proteine)-independent mechanism for targeting of GAD67 to synaptic vesicles in neurons is not functional in islet beta-cells.

Arabidopsis thaliana Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. mutations in the two lobes affect GAD1 activation in similar ways and only intact AtCaM1 can fully activate GAD1. Taken together, our data provide new insights into the CaM (zeige CALM Proteine) lobes role in interactions between CaM (zeige CALM Proteine) and plant GAD.

  2. Insertion mutants of GAD1 revealed that GABA levels in roots were drastically reduced compared with those in the wild type.

  3. Calmodulin (zeige CALM Proteine) activates Gad1 in a unique way by relieving two C-terminal autoinhibition domains of adjacent active sites, forming a 393 kDa Gad1-calmodulin (zeige CALM Proteine) complex with an unusual 1:3 stoichiometry.

Human Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. Reduced GAD67 expression in PV neurons is not an upstream cause of the lower levels of GABA-associated transcripts, or of the characteristic behaviors, in schizophrenia.

  2. Glutamic acid decarboxylase 67 (GAD67) is one of the isoforms that catalyze GABA synthesis. Here, we used recombinant herpes simplex virus (HSV-1) vectors that encode gad1 gene to evaluate the therapeutic potential of GAD67 in peripheral HIV gp120 (zeige ITIH4 Proteine)-induced neuropathic pain

  3. This study showed that in female groups, the expression of GABRA5 (zeige GABRA5 Proteine) was generally higher in schizophrenia cases compared to the control.

  4. GAD autoantibodies were associated with risk of developing type 1 diabetes.

  5. Conversion of GAD autoantibody is associated with patients with presumed type 2 diabetes.

  6. The GAD65 (zeige GAD2 Proteine)-independent mechanism for targeting of GAD67 to synaptic vesicles in neurons is not functional in islet beta-cells.

  7. Gene ransfer of GAD67 by herpes simplex virus vectors prevents HIV gp120 (zeige ITIH4 Proteine)/ddC (zeige DDC Proteine)-induced neuropathic pain.

  8. Phosphate-activated glutaminase (zeige GLS2 Proteine) and GAD65 (zeige GAD2 Proteine)/67 concentrations are compared in Alzheimer's disease cerebellum versus normal cerebellum controls

  9. results statistically show that a reduction in GAD1 and SCL1A2 expression in the dorsolateral prefrontal cortex in subjects with major depressive disorder is related to a possible attenuated RAF (zeige RAF1 Proteine)/MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) pathway

  10. CNR1 (zeige CNR1 Proteine), GAD1 and BDNF (zeige BDNF Proteine) polymorphisms are associated with male heroin dependence in the Dai (zeige ZBP1 Proteine) population in China.

Cow (Bovine) Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. These results suggest that the GAD1 gene is a strong candidate gene that affects growth traits in cattle.

Zebrafish Glutamate Decarboxylase 1 (Brain, 67kDa) (GAD1) Interaktionspartner

  1. relative expression domains of the dlx and gad1 genes in the zebrafish telencephalon and diencephalon

  2. High levels of GAD67 mRNA were observed in the intermediate and ventral parts of the medial pallium

  3. the distribution of GAD67-expressing cells highly resembles the distribution of gamma-aminobutyric acid (GABA)/GAD67-expressing cells found in the early zebrafish (teleost) forebrain, suggesting a prosomeric fate map of GABAergic cell populations

GAD (GAD1) Protein Überblick

Protein Überblick

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

Genbezeichner und Symbole assoziert mit GAD1

  • glutamate decarboxylase 1 (brain, 67kDa), gene 1 (gad1.1)
  • glutamate decarboxylase 1 (brain, 67kDa) (GAD1)
  • glutamate decarboxylase 1 (AOR_1_946174)
  • glutamate decarboxylase 1 (AOR_1_562034)
  • glutamate decarboxylase 1 (Gad1)
  • glutamate decarboxylase 1 (GAD)
  • glutamate decarboxylase 1b (gad1b)
  • ubiquitin carboxy-terminal hydrolase L1 (Uchl1)
  • AO090005000539 Protein
  • AO090103000342 Protein
  • AW822034 Protein
  • C88048 Protein
  • CPSQ1 Protein
  • EP10 Protein
  • gad Protein
  • Gad-1 Protein
  • GAD-67 Protein
  • GAD1 Protein
  • gad1-A Protein
  • GAD2 Protein
  • GAD25 Protein
  • GAD44 Protein
  • Gad67 Protein
  • glutamate decarboxylase Protein
  • GLUTAMATE DECARBOXYLASE 1 Protein
  • MKP11.30 Protein
  • MKP11_30 Protein
  • PGP9.5 Protein
  • PGP 9.5 Protein
  • R75593 Protein
  • SCP Protein
  • UCH-L1 Protein
  • UCHL-1 Protein

Bezeichner auf Proteinebene für GAD1

glutamate decarboxylase 1 , glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) , glutamic acid decarboxylase 65-like protein , 67 kDa glutamic acid decarboxylase , GAD-67 , GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE) , glutamate decarboxylase 67 kDa isoform , glutamic acid decarboxylase 1 , Glutamate decarboxylase 1 (brain) , glutamate decarboxylase 1 variant GAD67NT , glutamic acid decarboxylase , glutamate decarboxylase 67 , glutamate decarboxylase, 67 kDa isoform , gracile axonal dystrophy , neuron cytoplasmic protein 9.5 , protein gene product 9.5 , ubiquitin carboxyl-terminal hydrolase isozyme L1 , ubiquitin thioesterase L1

GENE ID SPEZIES
378551 Xenopus laevis
778442 Taeniopygia guttata
778447 Taeniopygia guttata
5989537 Aspergillus oryzae RIB40
5999037 Aspergillus oryzae RIB40
100173252 Pongo abelii
14415 Mus musculus
24379 Rattus norvegicus
831599 Arabidopsis thaliana
2571 Homo sapiens
493699 Felis catus
478794 Canis lupus familiaris
396928 Sus scrofa
517552 Bos taurus
395743 Gallus gallus
468557 Pan troglodytes
378441 Danio rerio
22223 Mus musculus
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