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Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. Zusätzlich bieten wir Ihnen Germ Cell Associated 2 (Haspin) Antikörper (53) und und viele weitere Produktgruppen zu diesem Protein an.
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This is the first structural model of a bisubstrate inhibitor targeting haspin. The presented structural data represent a model for the future development of more specific haspin inhibitors
Haspin kinase plays a key role in maintaining the slowly exchanging centromere Borealin (zeige CDCA8 Proteine) pool.
Haspin activity affects the phosphorylation state of proteins involved in gene expression regulation and splicing.
Haspin inhibitors reveal centromeric roles of Aurora B (zeige AURKB Proteine) in chromosome movement and spindle checkpoint signaling
Aurora B (zeige AURKB Proteine) phosphorylates Haspin to promote generation of H3T3ph and that Aurora B kinase (zeige AURKB Proteine) activity is required for normal chromosomal localization of the CPC, indicating an intimate linkage between Aurora B (zeige AURKB Proteine) and Haspin functions in mitosis
findings show phosphorylation of histone H3-threonine 3 mediated by Haspin cooperates with Bub1-mediated histone 2A-serine 121 phosphorylation in targeting the chromosomal passenger complex to the inner centromere in fission yeast and human cells
phosphorylation of H3T3 by Haspin is necessary for chromosomal passenger complex(CPC) accumulation at centromeres; Survivin (zeige BIRC5 Proteine) binds to H3T3ph; H3T3ph generated by Haspin positions CPC at centromeres to regulate selected targets of Aurora B (zeige AURKB Proteine) during mitosis
Haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion.
Haspin is a relatively newly discovered kinase that phosphorylates histone H3 (zeige HIST3H3 Proteine) during mitosis and appears to play a role in regulating chromosome behavior during cell division. [REVIEW]
This work reveals a new kinase involved in composing the histone code and adds haspin to the select group of kinases that integrate regulation of chromosome and spindle function during mitosis and meiosis
These data uncover a role for haspin as a regulator of bipolar spindle assembly by regulating AURKC (zeige AURKC Proteine) function at acentriolar microtubule-organizing centers in oocytes.
Data implicate haspin as a regulator of the chromosomal passenger complex and chromosome segregation during meiosis I.
the tissue-dependent and differentially methylated region functions as a modulator in a DNA methylation (zeige HELLS Proteine)-dependent manner; Gsg2 is under epigenetic control
the 193-bp DNA sequence in Haspin promotor is sufficient for the specific, bidirectional, and synchronous expression in germ cells in the testis.
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Ser-3' (H3T3ph) during mitosis. This positions and activates AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle (By similarity).
serine/threonine-protein kinase haspin-like protein
, germ cell associated 2 (haspin)
, putative serine/threonine-protein kinase haspin homolog
, germ cell-specific gene 2 protein
, haploid germ cell-specific nuclear protein kinase
, serine/threonine-protein kinase haspin