GRB2-Related Adaptor Protein Proteine (GRAP)

GRAP encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. Zusätzlich bieten wir Ihnen GRAP Antikörper (59) und GRAP Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GRAP 10750 Q13588
GRAP 71520 Q9CX99
Ratte GRAP GRAP 363616  
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.418,26 €
Details

GRAP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu GRB2-Related Adaptor Protein (GRAP) Interaktionspartnern

Human GRB2-Related Adaptor Protein (GRAP) Interaktionspartner

  1. Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from fibrotic kidneys from diabetic patients, and subsequently confirmed a (zeige TGFB1 Proteine)s a novel component of TGF-beta signaling in cultured human renal tubule cells.

  2. Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.

  3. Our findings define a pathway involving CD28 (zeige CD28 Proteine) binding to Grb-2 (zeige GRB2 Proteine) and its co-operativity with Vav1 (zeige VAV1 Proteine) in the regulation of T-cell co-stimulation.

Mouse (Murine) GRB2-Related Adaptor Protein (GRAP) Interaktionspartner

  1. Grb2-related adaptor protein (GRAP) was up-regulated in kidney tubules from diabetic mice, indicating a potential novel role for GRAP in TGF-beta (zeige TGFB1 Proteine)-induced tubule injury in diabetic kidney disease.

  2. Data suggest that Grap, unlike Grb2 (zeige GRB2 Proteine), acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk (zeige EPHB2 Proteine) pathway.

  3. Results suggest that the GRAP gene might have a role in the pathogenesis of Sjogren's syndrome.

  4. FcgammaRIIB docking site for the SH2 domain-containing adapters Grb2 (zeige GRB2 Proteine) and Grap

GRAP Protein Überblick

Protein Überblick

This gene encodes a member of the GRB2/Sem5/Drk family and functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. In general, it couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway.

Genbezeichner und Symbole assoziert mit GRAP

  • GRB2-related adaptor protein (GRAP)
  • GRB2-related adaptor protein a (grapa)
  • zgc:109892 (zgc:109892)
  • GRB2-related adaptor protein (Grap)
  • 8430435N19Rik Protein
  • BB233594 Protein
  • grap Protein
  • MGC109892 Protein
  • si:dkeyp-9d4.1 Protein
  • zgc:110202 Protein

Bezeichner auf Proteinebene für GRAP

GRB2-related adaptor protein , GRB2-related adapter protein , growth factor receptor-bound protein 2-related adaptor protein

GENE ID SPEZIES
416523 Gallus gallus
489534 Canis lupus familiaris
553596 Danio rerio
555184 Danio rerio
10750 Homo sapiens
71520 Mus musculus
363616 Rattus norvegicus
534491 Bos taurus
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