GLE1 RNA Export Mediator Homolog (Yeast) Proteine (GLE1)

GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Zusätzlich bieten wir Ihnen GLE1 RNA Export Mediator Homolog (Yeast) Antikörper (45) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
GLE1 2733 Q53GS7
GLE1 362098 Q4KLN4
GLE1 74412 Q8R322
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Showing 6 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
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Hefe Schizosaccharomyces pombe His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,356.83
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$4,033.33
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GLE1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Rat (Rattus)

Mouse (Murine)

Weitere Proteine zu GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Interaktionspartnern

Human GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Interaktionspartner

  1. It was concluded that the amyotrophic lateral sclerosis-linked Gle1-c.1965-2A>C mutation generates a protein isoform capable of both Gle1A- and Gle1B-ascribed functions, and thereby uncoupled from normal mechanisms of Gle1 regulation.

  2. We also suggest that lethal congenital contracture syndrome 1 (LCCS1) and lethal arthrogryposis with anterior horn disease (LAAHD), the two AMC subtypes related to GLE1, do not have sufficient clinical or molecular differentiation to be considered allelic disorders. Rather, GLE1 mutations cause a variable spectrum of AMC severity including a non-lethal variant described herein

  3. Restoration of miR (zeige MLXIP Proteine)-127-3p and miR (zeige MLXIP Proteine)-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1 (zeige UBXN11 Proteine), GLE1 and PDIA6 (zeige PDIA6 Proteine).

  4. We report the identification of the first heterozygous mutations in GLE1 ever found to be associated with amyotrophic lateral sclerosis.

  5. Lethal congenital contracture syndrome 1 and lethal arthrogryposis with anterior horn cell disease are associated with defective Gle1 function during the export of mRNA. [review]

  6. Report documents a requirement for Gle1 self-association during mRNA export and uncover molecular defects underlying a lethal human disease lethal congenital contracture syndrome-1.

  7. Dbp5, Gle1-IP6 (zeige GPRIN2 Proteine) and Nup159: a working model for mRNP export.

  8. defective zebrafish GLE1 function in human LCCS1 results in both neurogenic and non-neurogenic defects linked to the apoptosis of proliferative organ precursors

  9. The unique carboxyl-terminal 43 amino acid region of the hGle1B isoform mediates binding to the C-terminal non-phenylalanine- glycine region of the nucleoporin hCG1/NPL1.

  10. Mutations in mRNA export mediator GLE1 result in fetal motoneuron disease.

GLE1 RNA Export Mediator Homolog (Yeast) (GLE1) Protein Überblick

Protein Überblick

This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit GLE1

  • CG14749 gene product from transcript CG14749-RA (CG14749)
  • nucleoporin GLE1 (CpipJ_CPIJ014147)
  • RNA export factor Gle1 (SJAG_03847)
  • GLE1, RNA export mediator (GLE1)
  • GLE1 RNA export mediator (Gle1)
  • GLE1 RNA export mediator (yeast) (Gle1)
  • 4933405K21Rik Protein
  • AA553313 Protein
  • Dmel\\CG14749 Protein
  • GLE1 Protein
  • Gle1l Protein
  • hGLE1 Protein
  • LCCS Protein
  • LCCS1 Protein

Bezeichner auf Proteinebene für GLE1

CG14749-PA , nucleoporin GLE1 , GLE1 RNA export mediator homolog , GLE1-like protein , GLE1-like, RNA export mediator , GLE1 RNA export mediator-like (yeast

GENE ID SPEZIES
35849 Drosophila melanogaster
6047573 Culex quinquefasciatus
7050485 Schizosaccharomyces japonicus yFS275
417212 Gallus gallus
2733 Homo sapiens
362098 Rattus norvegicus
74412 Mus musculus
480704 Canis lupus familiaris
540982 Bos taurus
100172586 Pongo abelii
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