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FLI1 encodes a transcription factor containing an ETS DNA-binding domain. Zusätzlich bieten wir Ihnen Friend Leukemia Virus Integration 1 Antikörper (165) und Friend Leukemia Virus Integration 1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1 (zeige EWSR1 ELISA Kits)-FLI1 and its effectors has produced promising results.
Fusion of short fragments of EWSR1 (zeige EWSR1 ELISA Kits) to FLI1 is sufficient to recapitulate BAF (zeige BANF1 ELISA Kits) complex retargeting and EWS (zeige EWSR1 ELISA Kits)-FLI1 activities; studies thus demonstrate that the physical properties of prion (zeige PRNP ELISA Kits)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
In American cutaneous leishmaniasis caused by Leishmania braziliensis infection, MMP1 (zeige MMP1 ELISA Kits) is regulated by factors other than FLI1, and the influence of IL-6 (zeige IL6 ELISA Kits) on MMP1 (zeige MMP1 ELISA Kits) was independent of its effect on FLI1.
epithelial Fli1 deficiency might be involved in the systemic autoimmunity and selective organ fibrosis in systemic sclerosis (SSc (zeige CYP11A1 ELISA Kits)).
Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS (zeige EWSR1 ELISA Kits)-FLI1 fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.
loss of ERG (zeige ERG ELISA Kits) and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation.
study shows that FLI-1 is expressed variably in different subtypes of NSCLC, and its expression is related to clinicopathologic parameters and poorer prognosis
ERG (zeige ERG ELISA Kits) (or FLI1 if available) is useful marker for the diagnosis of Phosphaturic mesenchymal tumors.
FLI1 and MMP9 (zeige MMP9 ELISA Kits) position differently in prostate cancer than in normal tissue and prostate hyperplasia, whereas MMP2 (zeige MMP2 ELISA Kits) is repositioned in both prostate cancer and hyperplasia.
FLI1 promoter hypermethylation is associated with Colorectal Cancer.
These results provide the first evidences that Fli-1 positively regulates LPS (zeige TLR4 ELISA Kits)-induced IL-27 (zeige IL27 ELISA Kits) production in macrophages
protective against nephritis MRL/lpr (zeige FAS ELISA Kits) mice
Fli1 is epigenetically suppressed and is a potential predisposing factor in the pathogenesis of systemic sclerosis. (Review)
The short nose, otitis media, and hearing impairment in Jacobsen syndrome are likely because of hemizygosity for ETS1 (zeige ETS1 ELISA Kits) and FLI1.
Simultaneous downregulation of KLF5 (zeige KLF5 ELISA Kits) and Fli1 is a key feature underlying systemic sclerosis.
bosentan...increased DNA binding of Fli1 and the suppression of type I collagen expression in systemic sclerosis fibroblasts
FLI1 and GATA2 (zeige GATA2 ELISA Kits) are upstream regulators of SMAD1 (zeige SMAD1 ELISA Kits) and SMAD5 (zeige SMAD5 ELISA Kits) expression in endothelial cells.
These results demonstrate that Fli-1 is a novel regulator of the proinflammatory chemokine (zeige CCL1 ELISA Kits) MCP-1 (zeige CPT1B ELISA Kits).
Fli-1 directly increases the expression of IL-6 (zeige IL6 ELISA Kits) via promoter region binding. This represents one possible mechanism for the protective effect of decreased Fli-1 expression in lupus.
mesodermal Wnt3a (zeige WNT3A ELISA Kits)-mediated signaling via the transcription factor Lef1 (zeige LEF1 ELISA Kits) positively regulates EC specification (defined by kdrl expression) at the expense of primitive erythrocyte specification (defined by gata1 (zeige GATA1 ELISA Kits) expression) in zebrafish embryos.
Fli+ etsrp+ hemato-vascular progenitor cells proliferate at the lateral plate mesoderm during vasculogenesis in zebrafish.
These results showed that young thrombocytes have higher GATA1 (zeige GATA1 ELISA Kits) promoter activity, while mature thrombocytes have more fli1 gene promoter transcription.
fli1, and etsrp, demonstrated that erg (zeige KCNH2 ELISA Kits) and fli1 act cooperatively and are required for angiogenesis possibly via direct regulation of an endothelial cell junction molecule, VE-cadherin (zeige CDH5 ELISA Kits)
Interaction between EWSR1 (zeige EWSR1 ELISA Kits)/FLI1 and EWSR1 (zeige EWSR1 ELISA Kits) in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11\;22)(q24\;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4\;11)(q21\;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants.
Ewing sarcoma breakpoint region 2
, Friend leukemia integration 1 transcription factor
, Friend leukemia virus integration 1
, proto-oncogene Fli-1
, transcription factor ERGB
, fli-1 proto-oncogene
, friend leukemia integration 1 transcription factor-like
, Friend leukemia integration 1 transcription factor-like
, retroviral integration site protein Fli-1
, retroviral integration site protein Fli-1 homolog