Free Fatty Acid Receptor 2 Proteine (FFAR2)

FFAR2 encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. Zusätzlich bieten wir Ihnen FFAR2 Antikörper (87) und FFAR2 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
FFAR2 2867 O15552
Ratte FFAR2 FFAR2 292794 Q76EI6
FFAR2 233079 Q8VCK6
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Wheat germ Human Unkonjugiert   2 μg Anmelden zum Anzeigen 7 bis 8 Tage
406,59 €
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FFAR2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Free Fatty Acid Receptor 2 (FFAR2) Interaktionspartnern

Human Free Fatty Acid Receptor 2 (FFAR2) Interaktionspartner

  1. Compared with the control group, the densitometric quantification and mean density of GPR43 and ChAT proteins, and expression of GPR43 and CHAT genes, were significantly decreased in the patients with mixed refractory constipation.

  2. a single dose of soluble fibre was able to significantly reduce airway inflammation in stable asthma by downregulating GPR43 and GPR41 (zeige FFAR3 Proteine)

  3. Short-chain fatty acids lowered TNF-alpha (zeige TNF Proteine)-induced MCP-1 (zeige CCL2 Proteine) expression by reducing phosphorylation of p38 MAPK (zeige MAPK14 Proteine) and JNK (zeige MAPK8 Proteine) in a GPR41 (zeige FFAR3 Proteine)/GRP43-dependent manner in renal cortical epithelial cells.

  4. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (zeige STK19 Proteine) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (zeige GCG Proteine) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (zeige STK19 Proteine).

  5. the results of mutagenesis studies based on the crystal structure of hFFA1 bound to TAK (zeige CDK9 Proteine)-875 at 2.3 A resolution to identify important residues for orthosteric agonist 6e inducing FFA2 activation.

  6. Although both agonist and antagonist ligands contain negatively charged carboxylates that interact with two key positively charged arginine residues in transmembrane domains V and VII (zeige TH Proteine) of FFA2, there are clear differences in how these interactions occur.

  7. FFAR2 signaling occurs by divergent G protein pathways.

  8. GPR3 agonism potentiates insulin secretion in isolated islets.

  9. GPR43 expression is reduced in monocytes upon siRNA-knockdown of XBP1 (zeige XBP1 Proteine), while A549 cells overexpressing XBP1 (zeige XBP1 Proteine) displayed elevated GPR43 levels.

  10. FFAR2 is a potential therapeutic target of T1 diabetes, representing a link between immune response and glucose homeostasis.

Mouse (Murine) Free Fatty Acid Receptor 2 (FFAR2) Interaktionspartner

  1. loss of FFAR2 is associated with colon tumorigenesis.

  2. Gestational glucose tolerance in WT mice, but not Ffar2-/- mice improved while on antibiotics. Gestational glucose tolerance worsened in Ffar2-/- mice during a second pregnancy. Maternal Ffar2 expression had no effect on the growth rates and glucose and glucose tolerance in the offspring.

  3. FFA2 processes mediated by Gi signaling, whereas, in concert with blockade by the Gq/G11 (zeige STK19 Proteine) inhibitor FR900359, the inability of AZ1729 to mimic or regulate propionate-mediated release of GLP-1 (zeige GCG Proteine) from mouse colonic preparations defined this physiological response as an end point transduced via activation of Gq/G11 (zeige STK19 Proteine).

  4. A Western diet could aggravate the inflammatory colitis process; the activation of the GPR43 receptor pathway could be used as a new strategy to treat Crohn's Disease patients.

  5. FFAR2 signaling occurs by divergent G protein pathways.

  6. Data (including data from studies in knockout mice) suggest Ffar2 expression in pancreatic beta-cells plays role in gestational glucose homeostasis; this mechanism involves gut microbiome (which contributes to plasma short-chain fatty acid levels).

  7. High fat diet fed GPR43 KO mice develop glucose intolerance due to a defect in insulin (zeige INS Proteine) secretion, reduced beta-cell mass and expression of differentiation genes. GPR3 (zeige GPR3 Proteine) agonism potentiates insulin (zeige INS Proteine) secretion.

  8. GPR-43-deficient mice show a greatly decreased inflammatory reaction to knee injection of monosodium urate crystals in a mouse model of gout.

  9. FFAR2 is expressed in pancreatic beta cells and mediates an inhibition of insulin (zeige INS Proteine) secretion by coupling to Gi-type G proteins.

  10. These findings establish GPR43 as a sensor for excessive dietary energy, thereby controlling body energy utilization while maintaining metabolic homoeostasis.

FFAR2 Protein Überblick

Protein Überblick

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels.

Genbezeichner und Symbole assoziert mit FFAR2

  • free fatty acid receptor 2 (FFAR2)
  • free fatty acid receptor 2 (Ffar2)
  • FFA2R Protein
  • GPCR43 Protein
  • Gpr43 Protein

Bezeichner auf Proteinebene für FFAR2

G protein-coupled receptor 43 , G-protein coupled receptor 43 , free fatty acid activated receptor 2 , leukocyte-specific STAT-induced GPCR

GENE ID SPEZIES
2867 Homo sapiens
292794 Rattus norvegicus
233079 Mus musculus
Ausgewählte Anbieter für FFAR2 Proteine (FFAR2)
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