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A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fat. Zusätzlich bieten wir Ihnen Fibulin 4 Proteine (15) und Fibulin 4 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.
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the expression of fibulin-4 was negatively correlated with the malignant phenotype of endometrial cancer cells. Fibulin-4 may have the ability to suppress endometrial cancer cell invasion and proliferation
The results revealed that fibulin-4 expression was upregulated in osteosarcoma, and was positively correlated with low differentiation, lymph node metastasis, and poor prognosis. Fibulin-4 was also found to be over-expressed in highly invasive cell lines and in the highly invasive subclones
link between Fibulin-4 and the canonical Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway that may contribute to our understanding of the molecular mechanisms of OA
Findings suggested that fibulin-4 is important for the proteolytic activation of lysyl oxidase (zeige LOX Antikörper) which has a pivotal role in cross-linking of collagen and elastin (zeige ELN Antikörper).
Data indicates that Fibulin-4 is a novel gene that is found overexpressed in ovarian cancer and associated with poor prognostic clinicopathologic features.
pulmonary emphysema in aneurysmal Fibulin-4 deficient (Fibulin-4(R)) mice
Homozygous mutations in exon 7 of the FBLN4 gene can produce lethal vasculopathy.
This study demonstrated that fibulin-4 may serve as a new prognostic factor and as a potential therapeutic target for patients with cervical carcinoma.
The expression level of EFEMP2 is dramatically increased in colorectal cancer patients, even at the early stage, compared with healthy controls.
Studied Fibulin-4 expression in aortic wall to find out its role in aortic dissection development. Used samples of aortic wall from 10 patients operated for acute ascending aortic dissection and five patients for chronic ascending aortic dissection.
These data clearly establish a functional link between Ltbp-4L and fibulin-4 as a crucial molecular requirement for survival and elastogenesis in mice.
fibulin-4 seems to play a role in regulating tendon collagen fibrillogenesis, in addition to its essential function in elastogenesis.
These data provide new insights in the molecular interaction between Fibulin-4 and TGF-beta (zeige TGFB1 Antikörper) pathway regulation in the pathogenesis of aortic aneurysms.
Fibulin-4 serves as a potential scaffolding protein during collagen maturation in the extracellular space and loss of fibulin-4 disrupts collagen synthesis and maturation.
fibulin-4 plays a role in regulating collagen fibril assembly and offer a preclinical platform for developing treatments for autosomal recessive cutis laxa 1B.
MBP1 (zeige ENO1 Antikörper) inhibits Ab fibril formation in vitro and demonstrate the ability of MBP1 (zeige ENO1 Antikörper) to reduce Ab pathology and improve behavioral performance.
Smooth muscle cell (SMC (zeige DYM Antikörper))-specific deletion of Fibulin-4 knockout ascending aorta and carotid artery showed mechanical changes in the axial direction.
Compared to control SMCs, the modulus of Eln (zeige ELN Antikörper)-/- SMCs is reduced by 40%, but is unchanged in Fbln4-/- SMCs. The Eln (zeige ELN Antikörper)-/- SMC (zeige DYM Antikörper) modulus is rescued by soluble or alpha elastin (zeige ELN Antikörper) treatment.
A large number of extracellular matrix proteins have been found to contain variations of the epidermal growth factor (EGF) domain and have been implicated in functions as diverse as blood coagulation, activation of complement and determination of cell fate during development. The protein encoded by this gene contains four EGF2 domains and six calcium-binding EGF2 domains. This gene is necessary for elastic fiber formation and connective tissue development. Defects in this gene are cause of an autosomal recessive cutis laxa syndrome. Alternatively spliced transcript variants have been identified for this gene.
, EGF-containing fibulin-like extracellular matrix protein 2
, mutant p53 binding protein 1
, EGF-containing fibulin-like extracellular matrix protein 2 (Efemp2)
, mutant p53-binding protein 1
, Protein H411