Fibroblast Growth Factor 14 Proteine (FGF14)

The protein encoded by FGF14 is a member of the fibroblast growth factor (FGF) family. Zusätzlich bieten wir Ihnen FGF14 Antikörper (47) und FGF14 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
FGF14 2259 Q92915
FGF14 14169 P70379
FGF14 63851 Q8R5L7
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Top FGF14 Proteine auf antikoerper-online.de

Showing 10 out of 13 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
488,89 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
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HOST_Escherichia coli (E. coli) Hund Unkonjugiert 50 μg Anmelden zum Anzeigen 18 bis 20 Tage
450,00 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.507,30 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
484,01 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert   10 μg Anmelden zum Anzeigen 21 bis 26 Tage
148,50 €
Details

FGF14 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Am meisten referenzierte FGF14 Proteine

  1. Human FGF14 Protein expressed in Escherichia coli (E. coli) - ABIN2005837 : Zhao, Lim, Tan: Genetic analysis of SCA 27 in ataxia and childhood onset postural tremor. in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007 (PubMed)

Weitere Proteine zu Fibroblast Growth Factor 14 (FGF14) Interaktionspartnern

Human Fibroblast Growth Factor 14 (FGF14) Interaktionspartner

  1. Either the FGF14(V160A) or the FGF14(K74A/I76A) mutation was sufficient to abolish the FGF14-dependent regulation of peak transient Na(+) currents and the voltage-dependent activation and steady-state inactivation of Nav1.6 (zeige SCN8A Proteine); but only V160A with a concomitant alanine mutation at Tyr (zeige TYR Proteine)-158 could impede FGF14-dependent modulation of the channel fast inactivation.

  2. study reports on a two-generation French Canadian family affected with autosomal dominant episodic ataxia caused by a frameshift mutation leading to a premature stop codon in FGF14

  3. identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.

  4. family demonstrates phenotypic variability of FGF14 deletions (SCA 27), fever sensitivity of ataxia and the added value of SNP-array analysis in making a diagnosis

  5. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.

  6. THe present study demonstrates that Spinocerebellar ataxia type 27 (SCA27) caused by FGF14 mutation is rare in Chinese SCA patients.

  7. A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebral ataxia

  8. A G->A variant was found in a single spinocerebellar ataxia patient in the 3' untranslated region, 31 bp to the STOP codon; it did not affect the polyadenylation site. FGF14 mutations are not a major cause of SCA in Caucasians.

  9. Frameshift mutation and polymorphisms in the fibroblast growth factor 14 gene is associated with ataxias

  10. these findings implicate FGF14 as a unique modulator of Nav channel activity in the CNS.

Mouse (Murine) Fibroblast Growth Factor 14 (FGF14) Interaktionspartner

  1. TWEAK (zeige TNFSF12 Proteine)/Fn14 (zeige TNFRSF12A Proteine) pathway instrumental in the pathogenesis of spontaneous lupus nephritis

  2. FGF14 is localized in a decreasing proximal to distal gradient along the axon initial segment of Purkinje neurons.

  3. FGF14 regulates presynaptic Ca2 (zeige CA2 Proteine)+ channels and synaptic transmission in cultured rat neurons.

  4. inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.

  5. Fgf14-deficient mice developed ataxia and a paroxysmal hyperkinetic movement disorder. FGF14 may mediate neuronal signaling, axonal trafficking and synaptosomal function.

  6. FGF14 in regulating synaptic plasticity via presynaptic mechanisms by affecting the mobilization, trafficking, or docking of synaptic vesicles to presynaptic active zones.

  7. these results suggest a role for FGF14 in certain spatial learning functions and synaptic plasticity

  8. Sodium channels in Fhf1 (zeige FGF12 Proteine)-/-Fhf4-/- granule neurons inactivate at more negative membrane potential, inactivate more rapidly, and are slower to recover from the inactivated state.

  9. results suggest that FGF14 is required for normal Nav1.6 (zeige SCN8A Proteine) expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 (zeige SCN8A Proteine) channels

FGF14 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene.

Genbezeichner und Symbole assoziert mit FGF14

  • fibroblast growth factor 14 (FGF14)
  • fibroblast growth factor 14 (fgf14)
  • fibroblast growth factor 14 (LOC100229510)
  • fibroblast growth factor 14 (LOC100358876)
  • fibroblast growth factor 14 (Fgf14)
  • FGF-14 Protein
  • FGF14 Protein
  • FHF-4 Protein
  • Fhf4 Protein
  • mFHF-4(1B) Protein
  • SCA27 Protein

Bezeichner auf Proteinebene für FGF14

fibroblast growth factor homologous factor 4 , fibroblast growth factor 14 , bA397O8.2 , FGF-14 , FGF homologus factor 4b

GENE ID SPEZIES
395554 Gallus gallus
497642 Danio rerio
701077 Macaca mulatta
739338 Pan troglodytes
100217328 Xenopus (Silurana) tropicalis
100229510 Taeniopygia guttata
100358876 Oryctolagus cuniculus
2259 Homo sapiens
14169 Mus musculus
63851 Rattus norvegicus
485537 Canis lupus familiaris
615488 Bos taurus
Ausgewählte Anbieter für FGF14 Proteine (FGF14)
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