anti-Ewing Sarcoma Breakpoint Region 1 (EWSR1) Antikörper

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. Zusätzlich bieten wir Ihnen EWSR1 Proteine (4) und EWSR1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
EWSR1 14030 Q61545
EWSR1 2130 Q01844
EWSR1 289752  
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Top anti-EWSR1 Antikörper auf antikoerper-online.de

Showing 10 out of 153 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-EWSR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-EWSR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB <b>WB Suggested Anti-EWSR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-EWSR1 <br /> Antibody Titration: 0.2-1 µg/mL <br /> Positive Control: Jurkat cell lysate <br /> EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- EWSR1 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert IF, WB Western blot analysis of EWSR1 (arrow) using rabbit polyclonal EWSR1 Antibody (C-term) (ABIN658497). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EWSR1 gene. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Western blot analysis of EWS expression in HepG2 (A), Jurkat (B), HeLa (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert ELISA, WB   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Rind (Kuh) Ziege Unkonjugiert EIA, IHC (p), WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$375.38
Details
Human Ziege Unkonjugiert IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: EWSR1 Antibody [NBP1-28798] - (3.8ug/ml) staining of Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$408.19
Details
Human Kaninchen Unkonjugiert IP, WB Western Blot: EWSR1 Antibody  - Detection of Human and Mouse EWS by Western Blot. Samples: Whole cell lysate (15 and 50 ug) from HeLa and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-EWS antibody  used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 3 seconds. 100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$486.94
Details

EWSR1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Mouse (Murine)
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Rat (Rattus)
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Am meisten referenzierte anti-EWSR1 Antikörper

  1. Human Polyclonal EWSR1 Primary Antibody für ICC, IF - ABIN152318 : Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. in Cancer cell 2006 (PubMed)

  2. Human Polyclonal EWSR1 Primary Antibody für IP, WB - ABIN152319 : Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. in Biochemical and biophysical research communications 2012 (PubMed)

  3. Human Polyclonal EWSR1 Primary Antibody für IHC (p), IHC - ABIN449908 : Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. in Cancer research 2006 (PubMed)

Weitere Antikörper gegen EWSR1 Interaktionspartner

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaktionspartner

  1. Gnai1 (zeige GNAI1 Antikörper) function is impaired in the spinal cord of Ews/Ewsr1 KO mice

  2. EWS is normally O-GlcNAc glycosylated in the brain.

  3. glycosylation of EWS protein

  4. EWSR1 is involved in the post-transcriptional regulation of Uvrag (zeige UVRAG Antikörper) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  5. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (zeige BMP2 Antikörper) and BMP4 (zeige BMP4 Antikörper) expression.

  6. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (zeige PPARGC1A Antikörper) protein stability

  7. both Etv1 (zeige ETV1 Antikörper) and Ewsr1 were necessary for Fgf10 (zeige FGF10 Antikörper) expression and elongation of the limb bud.

  8. EWS is involved in post-transcriptional regulation of Col4a1 (zeige COL4A1 Antikörper) and CTGF (zeige CTGF Antikörper) via a Drosha (zeige DROSHA Antikörper)-miRNA-dependent pathway.

  9. These results demonstrate that EWS is essential for early brown fat lineage determination.

  10. Forced expression of EWS/ATF1 (zeige AFT1 Antikörper) resulted in the development of EWS/ATF1 (zeige AFT1 Antikörper)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (zeige AFT1 Antikörper)-driven transformation.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaktionspartner

  1. Mutation of the EWS gene modulates Sox9 (zeige SOX9 Antikörper) gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 (zeige FLI1 Antikörper) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) Interaktionspartner

  1. As spontaneous fluctuations in EWS-FLI1 (zeige FLI1 Antikörper) levels of Ewing sarcoma cells in vitro and in vivo, associated with a switch between a proliferative, non-migratory EWS-FLI1 (zeige FLI1 Antikörper)-high and a non-proliferative highly migratory EWS-FLI1 (zeige FLI1 Antikörper)-low state, were recently described, our data provide a mechanistic basis for the underlying EWS-FLI1 (zeige FLI1 Antikörper)-dependent reversible cytoskeletal reprogramming of Ewing sarcoma cells.

  2. Fusion of short fragments of EWSR1 to FLI1 (zeige FLI1 Antikörper) is sufficient to recapitulate BAF (zeige BANF1 Antikörper) complex retargeting and EWS-FLI1 (zeige FLI1 Antikörper) activities; studies thus demonstrate that the physical properties of prion (zeige PRNP Antikörper)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.

  3. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (zeige AFT1 Antikörper) gene fusion.

  4. Results expand the spectrum of tumor types harboring EWSR1/FUS (zeige FUS Antikörper)-ATF1 (zeige AFT1 Antikörper) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

  5. papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement

  6. The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (zeige FLI1 Antikörper) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.

  7. Aggregation of FET proteins FUS (zeige FUS Antikörper), EWSR1, and TAF15 (zeige TAF15 Antikörper) mediate a pathological change in amyotrophic lateral sclerosis. (Review)

  8. A subgroup of MAML2 (zeige MAML2 Antikörper) fusion-negative mucoepidermoid carcinomas are actually clear cell carcinoma of the salivary gland with EWSR1 translocation.

  9. Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS-FLI1 (zeige FLI1 Antikörper) fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.

  10. Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1 (zeige CREB1 Antikörper)/CREM (zeige CREM Antikörper) fusions.

EWSR1 Antigen-Profil

Protein Überblick

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Genbezeichner und Symbole assoziert mit EWSR1

  • EWS RNA binding protein 1 (EWSR1) Antikörper
  • EWS RNA binding protein 1 (ewsr1) Antikörper
  • Ewing sarcoma breakpoint region 1 (Ewsr1) Antikörper
  • EWS RNA-binding protein 1a (ewsr1a) Antikörper
  • EWS RNA-binding protein 1 (Ewsr1) Antikörper
  • AU018891 Antikörper
  • bK984G1.4 Antikörper
  • DKFZp459K1116 Antikörper
  • Ews Antikörper
  • Ewsh Antikörper
  • EWSR1 Antikörper
  • fc04c01 Antikörper
  • wu:fc04c01 Antikörper

Bezeichner auf Proteinebene für EWSR1

RNA-binding protein EWS , Ewing sarcoma RNA-binding protein , Ewing sarcoma breakpoint region 1 , Ewing sarcoma homolog , Ewings sarcoma EWS-Fli1 (type 1) oncogene

GENE ID SPEZIES
748264 Pan troglodytes
100034010 Equus caballus
100018014 Monodelphis domestica
100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
417022 Gallus gallus
609786 Canis lupus familiaris
534073 Bos taurus
14030 Mus musculus
100156911 Sus scrofa
323597 Danio rerio
2130 Homo sapiens
289752 Rattus norvegicus
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