Elastase, Neutrophil Expressed Proteine (ELANE)

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Zusätzlich bieten wir Ihnen Elastase, Neutrophil Expressed Antikörper (177) und Elastase, Neutrophil Expressed Kits (103) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ELANE 1991 P08246
ELANE 50701 Q3UP87
Ratte ELANE ELANE 299606  
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Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,960.83
Details
Human Human Unkonjugiert 10 μg Anmelden zum Anzeigen 6 bis 7 Tage
$109.63
Details
Escherichia coli (E. coli) Human His tag,GST tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$480.00
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Human Human Unkonjugiert   1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$632.50
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Human Human Unkonjugiert   200 μg Anmelden zum Anzeigen 6 bis 7 Tage
$843.33
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Human Cells Human Unkonjugiert   25 μg Anmelden zum Anzeigen 11 bis 12 Tage
$460.00
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Human Unkonjugiert   0.5 mg Anmelden zum Anzeigen 2 bis 3 Tage
$144.57
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Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 11 bis 18 Tage
$497.47
Details

ELANE Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine)

Am meisten referenzierte Elastase, Neutrophil Expressed Proteine

  1. Human ELANE Protein expressed in Human - ABIN2544352 : Luyendyk, Shaw, Green, Maddox, Ganey, Roth: Coagulation-mediated hypoxia and neutrophil-dependent hepatic injury in rats given lipopolysaccharide and ranitidine. in The Journal of pharmacology and experimental therapeutics 2005 (PubMed)

Weitere Proteine zu Elastase, Neutrophil Expressed (ELANE) Interaktionspartnern

Human Elastase, Neutrophil Expressed (ELANE) Interaktionspartner

  1. The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (zeige EIF2AK3 Proteine) and CHOP (zeige DDIT3 Proteine) is reported.

  2. results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (zeige ELN Proteine) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy

  3. Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.

  4. Data suggest that neuropilin-1 (NRP1 (zeige NRP1 Proteine)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (zeige TMEM37 Proteine) (a peptide fragment of NE) in breast cancer cells.

  5. This study proposes that acquisition of CSF3R (zeige CSF3R Proteine) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (zeige SRI Proteine) patients.

  6. Faecal biomarkers lactoferrin (zeige LTF Proteine), calprotectin (zeige S100A8 Proteine), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.

  7. In conclusion, site-specific CBG (zeige SERPINA6 Proteine) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (zeige C6orf108 Proteine) proteolysis by endogenous and exogenous elastases.

  8. Although circulating nucleosomes and elastase - alpha 1-antitrypsin (zeige SERPINA1 Proteine) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (zeige SLC44A2 Proteine) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.

  9. The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.

  10. The results of the present study may indicate that NE activates the phosphoinositide-3 kinase/Akt (zeige AKT1 Proteine) signaling pathway in leukemia cells to inhibit apoptosis and enhance cell proliferation

Mouse (Murine) Elastase, Neutrophil Expressed (ELANE) Interaktionspartner

  1. Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (zeige CEBPA Proteine)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (zeige CEBPA Proteine) are resistant to HFD-induced myelopoiesis.

  2. Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).

  3. Serine protease (zeige F2 Proteine) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock

  4. Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration

  5. results of ultrasound studies using the elastase and AngII apoE (zeige APOE Proteine) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity

  6. Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.

  7. SerpinA3N (zeige SERPINA3N Proteine) attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase

  8. Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.

  9. Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.

  10. In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions

Elastase, Neutrophil Expressed (ELANE) Protein Überblick

Protein Überblick

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.

Genbezeichner und Symbole assoziert mit ELANE

  • proteinase 3 (prtn3)
  • elastase, neutrophil expressed (ELANE)
  • chymotrypsin-like elastase family, member 2A (CELA2A)
  • elastase, neutrophil expressed (Elane)
  • Ela2 Protein
  • ELANE Protein
  • F430011M15Rik Protein
  • GE Protein
  • HLE Protein
  • HNE Protein
  • NE Protein
  • PMN-E Protein
  • SCN1 Protein

Bezeichner auf Proteinebene für ELANE

elastase 2, neutrophil , neutrophil elastase , elastase, neutrophil expressed , chymotrypsin-like elastase family member 2A , elastase-2 , elastase-2A , pancreatic elastase II , PMN elastase , bone marrow serine protease , granulocyte-derived elastase , human leukocyte elastase , leukocyte elastase , medullasin , polymorphonuclear elastase , serine protease

GENE ID SPEZIES
448597 Xenopus (Silurana) tropicalis
721134 Macaca mulatta
749897 Pan troglodytes
100301482 Felis catus
397197 Sus scrofa
1991 Homo sapiens
50701 Mus musculus
299606 Rattus norvegicus
442980 Canis lupus familiaris
100724414 Cavia porcellus
100126050 Bos taurus
100522182 Sus scrofa
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