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The protein encoded by ELK3 is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Zusätzlich bieten wir Ihnen ELK3, ETS-Domain Protein (SRF Accessory Protein 2) Proteine (5) und ELK3, ETS-Domain Protein (SRF Accessory Protein 2) Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ELK3 Primary Antibody für ICC, IF - ABIN4307745
Robertson, Wasylyk, Ye, Jung, Wasylyk: The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. in PLoS ONE 2014
Human Polyclonal ELK3 Primary Antibody für ICC, IF - ABIN4307747
Yang, Schramek, Adam, Keyes, Wang, Zheng, Fuchs: ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. in eLife 2016
Elk-3 contributes to the progression of liver fibrosis by modulating the epithelial-mesenchymal transition via the regulation of Egr-1 under MAPK signaling.
Elk3 has distinct roles in maintaining retinal artery integrity.
coexpression of KLF4 (zeige KLF4 Antikörper) led to repression of Elk-3 promoter activity
ELK3 suppresses PAI-1 (zeige SERPINE1 Antikörper) expression and accumulates in the nucleus at high cell density.
Data show that Elk-1 and Net do not contribute significantly to thymocyte development in the presence of SAP-1.
Elk-3 is a strong repressor of NOS2 promoter activity and mRNA levels, and endogenous expression of Elk-3 inversely correlates with NOS2
CTP:phosphocholine cytidylyltransferase (CT) messenger RNA(mRNA) increased at S-M phase corresponding to an increase of Ets-1 (zeige ETS1 Antikörper) protein mRNA and decrease of Net protein mRNA indicating that Net is an important endogenous repressor for CTalpha (zeige PCYT1A Antikörper) transcription
Net is a negative regulator of PAI-1 (zeige SERPINE1 Antikörper) expression and is thereby involved in cell migration.
Elk-3 serves as an important repressor of heme oxygenase 1 (HO-1 (zeige HMOX1 Antikörper)) gene transcription and contributes to the tight control of HO-1 (zeige HMOX1 Antikörper) gene regulation in the setting of inflammatory stimuli
the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles
The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues.
We revealed that activation of the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics.
Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB (zeige NFKB1 Antikörper) signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC (zeige VEGFC Antikörper) expression.
High expression of ELK3 is associated with migration and invasion of liver cancer stem cells.
results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP (zeige MMP14 Antikörper) expression
The oncogenic MicroRNA Hsa (zeige CD24 Antikörper)-miR (zeige MLXIP Antikörper)-155-5p targets the transcription factor ELK3 and links it to the hypoxia response.
ELK3 plays a negative role of VEGF (zeige VEGFA Antikörper)-induced angiogenesis through indirectly inhibiting ETS-1 (zeige ETS1 Antikörper) function.
Net and HIF1alpha (zeige HIF1A Antikörper) are components of distinct signaling pathways that are intricately linked
These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer.
The protein encoded by this gene is a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation\; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present.
ETS domain-containing protein Elk-3
, ETS-domain protein ELK-3
, ETS-related protein ERP
, ETS-related protein NET
, ELK3, member of ETS oncogene family
, ETS-domain protein
, SRF accessory protein 2
, serum response factor accessory protein 2
, ELK3, ETS-domain protein