E4F Transcription Factor 1 Proteine (E4F1)

The zinc finger protein encoded by E4F1 is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. Zusätzlich bieten wir Ihnen E4F1 Antikörper (22) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
E4F1 1877 Q66K89
E4F1 13560 Q8CCE9
Ratte E4F1 E4F1 681359  
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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E4F1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu E4F Transcription Factor 1 (E4F1) Interaktionspartnern

Human E4F Transcription Factor 1 (E4F1) Interaktionspartner

  1. Whole exome sequencing has unraveled the presence of pathogenic mutations in genes encoding non-mitochondrial proteins, such as in the transcription factor E4F1.

  2. results suggest that E4F1 may neutralize the capacity of HBx to activate a p53 (zeige TP53 Proteine)-dependent, metabolic and growth arrest phenotype in liver cells, thus possibly contributing to the viability and proliferation of HBV-infected cells

  3. Short hairpin RNA-mediated depletion of E4F1 induced mitochondrial defects and ROS-mediated death in several myeloid leukemia cell lines.

  4. association of p120E4F with p14ARF enhances cell cycle inhibition

  5. Specific inactivation of RASSF1A (zeige RASSF1 Proteine) by short interfering RNA disrupts binding of RASSF1A (zeige RASSF1 Proteine) to p120 (zeige HNRNPU Proteine)(E4F) in tumor cells.

  6. E4F1 function involves ER alpha (zeige ESR1 Proteine)-mediated inhibition of VSMC proliferation and estrogen-related atheroprotection of human

  7. findings show that full-length E4F1 protein but not its E1A (zeige BCKDHA Proteine)-activated & truncated form interacts in vitro & in vivo with FHL2 (zeige FHL2 Proteine); this E4F1-FHL2 (zeige FHL2 Proteine) association occurs in the nuclear compartment & inhibits the capacity of E4F1 to block cell proliferation

  8. E4F1 is a key posttranslational regulator of p53 (zeige TP53 Proteine), which modulates its effector functions involved in alternative cell fates: growth arrest or apoptosis.

  9. LANP (zeige ANP32A Proteine) and ATAXN1 interact in E4F-mediated transcriptional repression.

Mouse (Murine) E4F Transcription Factor 1 (E4F1) Interaktionspartner

  1. Acute inactivation of E4F1 in these cells results in CHK1 (zeige CHEK1 Proteine)-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS (zeige ROS1 Proteine) production, energy stress, and inhibition of de novo pyrimidine synthesis

  2. Altogether, our results classify E4F1 as a master regulator of CHK1 (zeige CHEK1 Proteine) activity that ensures high fidelity of DNA replication, thus safeguarding genome stability.

  3. deletion of E4F1 resulted in the death of histiocytic sarcoma cells and tumor regression in vivo and extended the lifespan

  4. identify a regulatory axis essential for epidermal stem cell-dependent skin homeostasis implicating E4F1 and the Bmi1 (zeige BMI1 Proteine)-Arf-p53 (zeige TP53 Proteine) pathway.

  5. Results establish a crucial role for E4F during early embryonic cell cycles and reveal an unexpected function for E4F in mitosis.

E4F1 Protein Überblick

Protein Überblick

The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.

Genbezeichner und Symbole assoziert mit E4F1

  • E4F transcription factor 1 (E4F1)
  • E4F transcription factor 1 (e4f1)
  • E4F transcription factor 1 (LOC100224725)
  • E4F transcription factor 1 (E4f1)
  • Dnase1l2 Protein
  • E4F Protein
  • MGC147041 Protein
  • zgc:114190 Protein

Bezeichner auf Proteinebene für E4F1

transcription factor E4F1 , E4F transcription factor 1 , p120E4F , transcription factor E4F1-like , p50E4F , putative E3 ubiquitin-protein ligase E4F1 , transcription factor E4F , transcription factor phi AP3 , deoxyribonuclease 1-like 2

GENE ID SPEZIES
515997 Bos taurus
100517704 Sus scrofa
100683433 Canis lupus familiaris
416560 Gallus gallus
454356 Pan troglodytes
548399 Xenopus (Silurana) tropicalis
695882 Macaca mulatta
100190769 Xenopus laevis
100224725 Taeniopygia guttata
100404813 Callithrix jacchus
100552753 Anolis carolinensis
100580177 Nomascus leucogenys
1877 Homo sapiens
13560 Mus musculus
681359 Rattus norvegicus
561158 Danio rerio
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