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DMRT1 is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). Zusätzlich bieten wir Ihnen DMRT1 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal DMRT1 Primary Antibody für IHC, IHC (p) - ABIN4305451
von Kopylow, Staege, Spiess, Schulze, Will, Primig, Kirchhoff: Differential marker protein expression specifies rarefaction zone-containing human Adark spermatogonia. in Reproduction (Cambridge, England) 2012
Show all 3 Pubmed References
dmrt1 functions in male sexual fate in zebrafish and is essential for normal development of testis tubules and spermatogenesis.
Data indicate taht monocrotophos (MCP) exposure modulated gene expression of forkhead transcription factor gene L2 (foxl2), doublesex/mab-3 related transcription factor 1 (dmrt1), gonadal aromatase (cyp19a1a) and brain aromatase (cyp19a1b).
Dmrt1 gene is not only associated with testis development, but also, may be important in ovary differentiation of zebrafish
DMRT1 might influence sex-specific patterns of childhood asthma, and its expression in testis tissue and lung macrophages suggests a potential involvement in hormone or immune cell regulation.
The results suggest a role of changes in DMRT1 dosage in non-obstructive azoospermia potentially also through a process of gene misregulation, even though DMRT1 deleterious variants seem to be rare.
The role of DMT1 in mitochondrial iron acquisition by immunofluorescence with mitochondrial markers in cells and isolated mitochondria, as well as flow cytometric quantification of DMT1-positive mitochondria from an inducible expression system.
Point mutations of DMRT1 may be rarely associated with male infertility.
The combined results indicate that DMRT1 loss-of-function mutations are a risk factor and potential genetic cause of human spermatogenic failure
neither DMRT1 nor FGF9 abnormalities are frequently involved in dysgenetic male gonad development in patients with non-syndromic 46,XY disorder of sex development.
Meiosis signalling is dysregulated in carcinoma in situ (CIS (zeige CISH Antikörper)) cells and that a key regulator of the mitosis-meiosis switch, DMRT1, is expressed in 'early-stage' CIS (zeige CISH Antikörper) cells but is down-regulated with further invasive transformation.
The biological importance of the changes in expression of DMRT1 in Sertoli cells remains to be established, but it is consistent with DMRT1 reinforcing the inhibition of meiosis in the testis.
variants in or near BAK1 (zeige BAK1 Antikörper), DMRT1, TERT (zeige TERT Antikörper)-CLPTM1L (zeige CLPTM1L Antikörper), and KITLG (zeige KITLG Antikörper) predispose to familial and bilateral TGCT.
There is evidence that DMT1 expression and function respond rapidly to changes in dietary iron content
Concluding, this study shows that, in addition to its crucial role in testis development, Sox9 (zeige SOX9 Antikörper), together with Sox8 (zeige SOX8 Antikörper) and coordinately with Dmrt1, also controls adult testis maintenance.
miR (zeige MLXIP Antikörper)-224 overexpression increases the expression of GFRalpha1 (zeige GFRA1 Antikörper) and PLZF (zeige ZBTB16 Antikörper), accompanied by the down-regulation of DMRT1 in mouse testes.
Dmrt1 supports spermatogonial stem cell pool homeostasis.
DMRT1 expression in the ovary silenced the female sex-maintenance gene Foxl2 (zeige FOXL2 Antikörper) and reprogrammed juvenile and adult granulosa cells into Sertoli-like cells, triggering formation of structures resembling male seminiferous tubules.
Enforced expression of Dmrt1 in XX mouse fetal gonads using a Wt1 (zeige WT1 Antikörper)-BAC transgene system is sufficient to drive testicular differentiation and male secondary sex development.
spontaneous SSC (zeige CYP11A1 Antikörper) reprogramming is caused by unstable DNA methylation (zeige HELLS Antikörper) and that a Dmrt1-Sox2 (zeige SOX2 Antikörper) cascade is critical for regulating pluripotency in SSCs
DMRT1 controls pluripotency via transcriptional repression of Esrrb, Nr5a2/Lrh1 (zeige NR5A2 Antikörper), and Sox2 (zeige SOX2 Antikörper).
DMRT1 controls Stra8 (zeige STRA8 Antikörper) sex-specifically, activating it in the fetal ovary and repressing it in the adult testis.
sexual fate is surprisingly labile in the testis: loss of the DMRT1 transcription factor in mouse Sertoli cells, even in adults, activates Foxl2 (zeige FOXL2 Antikörper) and reprograms Sertoli cells into granulosa cells
These results suggest that novel ncRNA gene Dmr (zeige WDR20 Antikörper) might play a negative regulatory role for Dmrt1 in male sexual development.
This gene is found in a cluster with two other members of the gene family, having in common a zinc finger-like DNA-binding motif (DM domain). The DM domain is an ancient, conserved component of the vertebrate sex-determining pathway that is also a key regulator of male development in flies and nematodes. This gene exhibits a gonad-specific and sexually dimorphic expression pattern. Defective testicular development and XY feminization occur when this gene is hemizygous.
doublesex- and mab-3-related transcription factor 1
, doublesex and mab-3 related transcription factor 1
, DM domain-containing transcription factor DMRT1
, DM domain expressed in testis 1
, DM domain expressed in testis protein 1