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DPP10 encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. Zusätzlich bieten wir Ihnen Dipeptidylpeptidase 10 Antikörper (101) und Dipeptidylpeptidase 10 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human DPP10 Protein expressed in Human Cells - ABIN2004764
Allen, Heinzmann, Noguchi, Abecasis, Broxholme, Ponting, Bhattacharyya, Tinsley, Zhang, Holt, Jones, Lench, Carey, Jones, Dickens, Dimon, Nicholls, Baker, Xue, Townsend, Kabesch, Weiland, Carr et al.: Positional cloning of a novel gene influencing asthma from chromosome 2q14. ... in Nature genetics 2003
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The stoichiometry of the Kv4.2-DPP10 complex was variable depending on the relative expression level of each subunit, with a preference for 4:2 stoichiometry
the interaction of DPP10a, expressed in human atrium, with Kv4.3 (zeige KCND3 Proteine) channels generates a sustained current component of Ito, which may affect late repolarization phase of atrial action potentials.
study suggests a genetic contribution of DPP10 rs17048175 in eosinophilic inflammation induction in the airways and to aspirin-exacerbated respiratory disease susceptibility
Our results suggest that DPP10(789) is involved in the pathology of AD and other neurodegenerative diseases.
demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 (zeige KCNC1 Proteine) channels
Crystals of DPP10 obtained by the sitting-drop method were orthorhombic, belonging to space group P2(1)2(1)2(1) with unit-cell parameters a = 80.91, b = 143.73, c = 176.25 A.
N-linked glycosylation of DPP10 plays an important role in modulating Kv4.3 (zeige KCND3 Proteine) channel/KCHIP2 (zeige KCNIP2 Proteine) complex activities.
We were unable to confirm associations of single nucleotide polymorphisms of the positional candidates DPP10 and PHF11 with wheeze. Significant associations with reported and examined eczema were only observed for DPP10.
Our study is the first one to provide additional evidence that supports the roles of DPP10 in influencing asthma or BHR in a Chinese population
rs10208402 associated with percentage of peripheral blood eosinophils and log(e)-transformed total IgE in a Han Chinese population
In the presence of DPP6 (zeige DPP6 Proteine) or DPP10, cell surface Kv4.2 (zeige KCND2 Proteine) protein expression is selectively increased.
This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
, dipeptidyl peptidase 10
, dipeptidyl peptidase IV-related protein 3
, dipeptidyl peptidase X
, dipeptidyl peptidase like protein 2
, dipeptidyl peptidase-like protein 2
, inactive dipeptidyl peptidase 10
, Kv4 potassium channel auxiliary subunit