Differentially Expressed in FDCP 6 Homolog (Mouse) Proteine (DEF6)

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen DEF6 Antikörper (68) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
DEF6 23853 Q8C2K1
DEF6 50619 Q9H4E7
Ratte DEF6 DEF6 309642  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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DEF6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartnern

Zebrafish Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartner

  1. Swap70b and Def6a delineate Wnt11 (zeige WNT11 Proteine) and Wnt5b (zeige WNT5B Proteine) signalling pathways and have roles in convergent and extension cell movement during zebrafish gastrulation

  2. def6 morphants phenocopy Wnt5b (zeige WNT5B Proteine) mutants and ectopic overexpression of def6 essentially rescues Wnt5b (zeige WNT5B Proteine) morphants, indicating a novel role for def6 as a central GEF (zeige SLC2A4RG Proteine) downstream of Wnt5b (zeige WNT5B Proteine) signaling

Mouse (Murine) Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartner

  1. DEF6 and SWAP70 (zeige SWAP70 Proteine) are SWEF proteins with important contributors to hematopoietic stem and precursor cells biology

  2. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions

  3. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling.

  4. SLAT is an IP3R1 (zeige ITPR1 Proteine)-interacting protein required for T cell activation.

  5. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes.

  6. Data suggest that SLAT acts as a negative modulator of RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis.

  7. SLAT-mediated nuclear factor of activated T-cell (zeige NFATC3 Proteine) (NFAT)1 (zeige NFAT1 Proteine) activation is required for efficient expansion of CD8 (zeige CD8A Proteine)+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation.

  8. SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis.

  9. plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 (zeige ZAP70 Proteine) signaling

  10. tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT (zeige NFATC1 Proteine)-dependent CD4 (zeige CD4 Proteine)(+) T cell differentiation.

Human Differentially Expressed in FDCP 6 Homolog (Mouse) (DEF6) Interaktionspartner

  1. this study identifies Def6 (zeige DEFA6 Proteine) as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions

  2. DEF6 expression may serve as an independent prognostic factor, and interacted positively with p16 toward high tumor stage and shorter survival.

  3. IBP (zeige TSPO Proteine) was expressed ectopically in someoral squamous cell carcinoma samples and correlated significantly with tumor size, differentiation, clinical stage and distant metastases

  4. DEF6, a novel substrate for the Tec kinase ITK, contains a glutamine-rich aggregation-prone region and forms cytoplasmic granules that co-localize with P-bodies.

  5. Molecular cloning of IBP (zeige TSPO Proteine), a guanine nucleotide exchange factor (zeige RASGRF1 Proteine), which is highly expressed in the immune system.

  6. IBP (zeige TSPO Proteine) is a novel guanine nucleotide exchange factor (zeige RASGRF1 Proteine) and is recruited to the immunological synapse by T cell receptor engagement

  7. DEF6 not only activates Rho-family GTPases but also cooperates with activated Rac1 to exert its cellular function

  8. Overexpression of the Interferon regulatory factor 4 (zeige IRF4 Proteine)-binding protein is associated with Colorectal Carcinoma.

  9. DEF6 (zeige DEFA6 Proteine), a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42 (zeige CDC42 Proteine), and RhoA (zeige RHOA Proteine).

DEF6 Protein Überblick

Protein Überblick

DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003

Genbezeichner und Symbole assoziert mit DEF6

  • DEF6, guanine nucleotide exchange factor (DEF6)
  • differentially expressed in FDCP 6a homolog (mouse) (def6a)
  • DEF6, guanine nucleotide exchange factor L homeolog (def6.L)
  • DEF6, guanine nucleotide exchange factor (def6)
  • differentially expressed in FDCP 6 (Def6)
  • DEF6 guanine nucleotide exchange factor (Def6)
  • 2410003F05Rik Protein
  • 6430538D02Rik Protein
  • AV094905 Protein
  • Def6 Protein
  • IBP Protein
  • MGC68775 Protein
  • SLAT Protein
  • Slat2 Protein
  • Slat6 Protein
  • SWAP70L Protein
  • zgc:63721 Protein

Bezeichner auf Proteinebene für DEF6

differentially expressed in FDCP 6 homolog (mouse) , differentially expressed in FDCP 6 homolog , DEF-6 , IRF-4-binding protein , IRF4-binding protein , SWAP-70-like adapter of T-cells , SWAP-70-like adaptor protein of T cells

GENE ID SPEZIES
419893 Gallus gallus
462636 Pan troglodytes
394015 Danio rerio
398924 Xenopus laevis
100498543 Xenopus (Silurana) tropicalis
100053351 Equus caballus
23853 Mus musculus
50619 Homo sapiens
608163 Canis lupus familiaris
100154998 Sus scrofa
516457 Bos taurus
309642 Rattus norvegicus
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