Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
DSG4 encodes a member of the desmoglein subgroup of desmosomal cadherins. Zusätzlich bieten wir Ihnen Desmoglein 4 Antikörper (30) und Desmoglein 4 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
Showing 3 out of 3 products:
This study further extends the body of evidence that mutations in the DSG4 gene result in both hypotrichosis and monilethrix-like scalp hair.
Epitopes of Dsg4 may play a role in the pathogenesis of pemphigus vulgaris (zeige DSG3 ELISA Kits) .
show that HOXC13, LEF1 (zeige LEF1 ELISA Kits) and FOXN1 (zeige FOXN1 ELISA Kits) repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch (zeige NOTCH1 ELISA Kits) pathway with the activation and/or maintenance of DSG4 expression in the hair follicle.
the human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 (zeige DSG1 ELISA Kits) and DSG3 (zeige DSG3 ELISA Kits).
The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. We also show that DSG4 is an autoantigen in pemphigus vulgaris (zeige DSG3 ELISA Kits).
DSG4 is pathogenic in pemphigus and staphylococcal scalded skin syndrome.
The DSG4 protein is expressed in the more highly differentiated layers of the epidermis.
identification of a single nucleotide deletion within exon 3 of DSG4, designated 87delG in a Pakistani family with localized autosomal recessive hypotrichosis; this results in a frameshift and premature termination codon 162 bp downstream of the deletion
show that HOXC13, LEF1 (zeige LEF1 ELISA Kits) and FOXN1 (zeige FOXN2 ELISA Kits) repress DSG4 transcription and provide in vitro and in vivo evidence correlating the Notch (zeige NOTCH1 ELISA Kits) pathway with the activation and/or maintenance of DSG4 expression in the hair follicle.
Mast cell hyperplasia is associated with Dsg4-deficient hypotrichosis mice.
Smad4 (zeige SMAD4 ELISA Kits) loss-associated Dsg4 depletion contributed, at least in part, to hair follicles degeneration in Smad4 (zeige SMAD4 ELISA Kits) deficient skin.
This gene encodes a member of the desmoglein subgroup of desmosomal cadherins. The encoded protein is a transmembrane component in desmosomes and may play a role in cell-cell adhesion in epithelial cells. Mutations in the gene are associated with localized autosomal recessive hypotrichosis and potentially in other skin disorders. Alternate splicing results in multiple transcript variants.
, CDH family member 13
, cadherin family member 13
, lanceolate hair