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The protein encoded by CRX is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. Zusätzlich bieten wir Ihnen Cone-Rod Homeobox Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal CRX Primary Antibody für ELISA, WB - ABIN560473
Peng, Chen: Crx activates opsin transcription by recruiting HAT-containing co-activators and promoting histone acetylation. in Human molecular genetics 2007
Show all 10 Pubmed References
Human Monoclonal CRX Primary Antibody für RNAi, ELISA - ABIN560472
Gong, Sagiv, Cai, Tsang, Del Priore: Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors. in Experimental eye research 2008
Human Monoclonal CRX Primary Antibody für ELISA, WB - ABIN514613
Terrell, Xie, Workman, Mahato, Zelhof, Gebelein, Cook: OTX2 and CRX rescue overlapping and photoreceptor-specific functions in the Drosophila eye. in Developmental dynamics : an official publication of the American Association of Anatomists 2011
CRX can influence the development and opsin (zeige RHO Antikörper) expression of photoreceptor outer segments in zebrafish.
The CRX protein can recognize the BAT 1 (zeige DDX39B Antikörper) regulatory region contains highly conserved OTX (GATTA) and OTX-like (TATTA) sequences.
No mutation in crx were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to crx.
data demonstrate the successful application of ZFN technology to generate CRX-GFP labeled hESC lines, which can be used to study and isolate photoreceptor precursors during hESC differentiation.
Loss of OTX2 (zeige OTX2 Antikörper) expression resulted in decreased expression of C-MYC (zeige MYC Antikörper) and CRX, genes previously implicated in retinoblastoma tumorigenesis. Loss of OTX2 (zeige OTX2 Antikörper) expression increased the phosphorylation of RB, a potential mechanism of modulating cell proliferation
Mutations involving the CRX gene may demonstrate an autosomal dominant inheritance pattern for leber congenital amaurosis.
Con (zeige DISP1 Antikörper) rod homeobox protein mRNA is a novel marker for retinoblastoma at extraocular sites.
Two de novo mutations in CRX were found in Chinese patients with Leber congenital amaurosis. The CRX mutation might create a dominantly inherited trait.
Mutations in CRX demonstrate significant phenotypic heterogeneity both between and within pedigrees. A novel, adult-onset, macular dystrophy phenotype is characterized, further extending our knowledge of the etiology of dominant macular dystrophies.
CRX could be useful in surgical neuropathology for the differential diagnosis of pineal region tumors, in particular to discriminate pineal tumors from glial tumors
Data have identified a novel retinal SAM (zeige TTN Antikörper) domain protein, Samd7, which could act as a transcriptional repressor involved in fine-tuning of Crx-regulated gene expression.
the potential utility of CRX as a marker of pineal lineage in routine diagnostic neuropathology.
These findings suggest that CRX is a useful marker to discriminate metastatic retinoblastoma from other, more common, malignant small round cell tumors of childhood
OTR1 (zeige OXTR Antikörper), OTX2 (zeige OTX2 Antikörper) and CRX act as positive modulators of the BEST1 (zeige BEST1 Antikörper) promoter in the retinal pigment epithelium.
The L253X mouse provides a valuable model for CRX-associated retinopathy. The pathogenicity of CRX frameshift mutations depends on the position of the premature termination codon, which in turn determines the degree of mutant mRNA/protein overproduction.
CRX-associated retinopathies stem from graded changes in photoreceptor gene expression, which could significantly contribute to phenotypic variability.
Rax (zeige RAX Antikörper) and Crx cooperatively transactivate Rhodopsin (zeige RHO Antikörper) and cone opsin (zeige RHO Antikörper) promoters and an optimum Rax (zeige RAX Antikörper) expression level to transactivate photoreceptor gene expression exists.
E168d2 and R90W are mechanistically distinct mouse models for CRX-associated disease that will allow the elucidation of molecular mechanisms and testing of novel therapeutic approaches for different forms of CRX-associated disease.
The rhythmic nature of pineal CRX protein may directly modulate the daily profile of Aanat (zeige AANAT Antikörper) expression by inducing nighttime expression of this enzyme, facilitating nocturnal melatonin synthesis
We conclude that nucleotide changes in evolutionary conserved crx binding site could impact retina-specific expression levels of Kcnv2 (zeige KCNV2 Antikörper).
In Crx-knockout mice vasopressin (zeige AVP Antikörper) mRNA expression in the suprachiasmatic nucleus shows significant daily rhythm.
Our results show that NRL (zeige NRL Antikörper) and CRX together control the expression of most, if not all, genes involved in rod phototransduction through a cis (zeige CISH Antikörper)-regulatory module
Crx broadly modulates the pineal transcriptome and also influences differential night/day gene expression in this tissue
The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
, homeobox protein otx5
, orthodenticle homolog 5
, cone-rod homeobox protein
, orthodenticle homeobox 3
, crx gene for cone-rod homeobox protein
, photoreceptor-specific cone-rod homeobox protein
, cone-rod homeobox containing