Collagen, Type XXV, alpha 1 Proteine (COL25A1)

COL25A1 encodes a brain-specific membrane associated collagen. Zusätzlich bieten wir Ihnen COL25A1 Antikörper (60) und COL25A1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
COL25A1 84570 Q9BXS0
COL25A1 77018 Q99MQ5
Ratte COL25A1 COL25A1 687064  
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Showing 3 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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COL25A1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Collagen, Type XXV, alpha 1 (COL25A1) Interaktionspartnern

Human Collagen, Type XXV, alpha 1 (COL25A1) Interaktionspartner

  1. We identified COL25A1 mutations as a cause of autosomal-recessive congenital cranial dysinnervation disorder.

  2. COL25A1 methylation correlates with severity of cervical intraepithelial neoplasia

  3. The COL25A1 single nucleotide polymorphism rs13134663 was significantly associated with antisocial personality disorder, especially in subjects with comorbid substance dependence.

  4. The next best locus for gene x gender interactions for age at onset was in COL25A1 gene at 4q25

  5. provides genetic evidence of association between COL25A1 and risk for Alzheimer's disease

  6. COL25A1 leads to Alzheimer's disease-like pathology in vivo

  7. CLAC displays features characteristic of a collagen protein, ie. it forms a partly protease-resistant triple-helical structure, exhibits an intermediate affinity for heparin, and is glycosylated; binding domain between CLAC and amyloid beta-peptide

  8. Results show that collagenous Alzheimer amyloid plaque component (CLAC) assembles amyloid-beta fibrils into fibril bundles that have an increased resistance to proteases.

  9. suggest that CLAC becomes involved at an intermediate stage in the pathogenesis of Alzheimer's disease by binding to Abeta (zeige APP Proteine) fibrils, including fibrils formed from peptides with truncated N- or C-termini, and thereby slows their growth

Mouse (Murine) Collagen, Type XXV, alpha 1 (COL25A1) Interaktionspartner

  1. CLAC-P/collagen XXV is a novel essential factor that regulates the initial phase of intramuscular motor innervation, which is required for subsequent target-dependent motoneuron survival and neuromuscular junction formation during development.

  2. COL25A1 leads to Alzheimer's disease-like pathology in vivo

COL25A1 Protein Überblick

Protein Überblick

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit COL25A1

  • collagen, type XXV, alpha 1 (COL25A1)
  • collagen, type XXV, alpha 1 (col25a1)
  • collagen, type XXV, alpha 1 (Col25a1)
  • 2700062B08Rik Protein
  • AMY Protein
  • CLAC Protein
  • CLAC-P Protein
  • CLACP Protein
  • COL25A1 Protein

Bezeichner auf Proteinebene für COL25A1

collagen, type XXV, alpha 1 , collagen, type XXV, alpha 1-like , collagen alpha-1(XXV) chain-like , alzheimer disease amyloid-associated protein , collagen alpha-1(XXV) chain , collagen-like Alzheimer amyloid plaque component , collagenous Alzheimer amyloid plaque component , procollagen, type XXV, alpha 1

GENE ID SPEZIES
429900 Gallus gallus
461429 Pan troglodytes
610442 Canis lupus familiaris
615661 Bos taurus
697122 Macaca mulatta
100072894 Equus caballus
100449602 Pongo abelii
100564591 Anolis carolinensis
100589227 Nomascus leucogenys
84570 Homo sapiens
77018 Mus musculus
687064 Rattus norvegicus
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