Collagen, Type I, alpha 2 Proteine (COL1A2)

COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Zusätzlich bieten wir Ihnen Collagen, Type I, alpha 2 Antikörper (97) und Collagen, Type I, alpha 2 Kits (63) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
COL1A2 1278 P08123
COL1A2 12843 Q01149
Ratte COL1A2 COL1A2 84352 P02466
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.550,95 €
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
624,76 €
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HOST_Escherichia coli (E. coli) Hund GST tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
731,43 €
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COL1A2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
,
Mouse (Murine)

Weitere Proteine zu Collagen, Type I, alpha 2 (COL1A2) Interaktionspartnern

Human Collagen, Type I, alpha 2 (COL1A2) Interaktionspartner

  1. Identify PDGFRbeta as a driver in activating Akt (zeige AKT1 Proteine)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  2. Flightless-I (Drosophila) homolog (FLII (zeige FLII Proteine)) activates TGFbeta1 (zeige TGFB1 Proteine)-mediated expression of COL1A2 gene.

  3. In the individuals with a COL1A2 mutation, 80% (8/10) of those with a glycine substitution located C terminal of p.Gly211 exhibited DGI (zeige DSG1 Proteine) in both dentitions while no individual (0/5) with a mutation N-terminal of this point (p = 0.007) exhibited DGI (zeige DSG1 Proteine) in either dentition.

  4. COL1A2 expression was positively related to tumor size, depth of invasion, and to lower overall survival of gastric cancer patients.

  5. the present study demonstrated that the INS (zeige INS Proteine)/DEL polymorphism in the 3'UTR of COL1A2 is able to interfere with the interaction between miRNA and mRNA. In addition, it is the first study, to the best of our knowledge, to indicate that the minor allele (Del) is associated with a reduced risk of developing osteoporosis.

  6. These findings may improve understanding of the pathogenic gene mutation spectrum and the clinical manifestations of mutations of COL1A1 (zeige COL1A1 Proteine) and COL1A2 genes in Chinese patients with OI.

  7. THBS2 (zeige THBS2 Proteine), but not COL1A2 and SPP1 (zeige SPP1 Proteine), may serve as an indicator of gastric cancer prognosis.

  8. spine radiographs and charts of 437 patients (227 female) with osteogenesis imperfecta caused by mutations in COL1A1 (zeige COL1A1 Proteine) or COL1A2 were evaluated and compared the relationship between scoliosis, genotype and bisphosphonate treatment history.

  9. The overexpression of let7b was observed to upregulate the protein expression levels of COL1A1 (zeige COL1A1 Proteine) and COL1A2, while knockdown of let7b reduced the levels of COL1A1 (zeige COL1A1 Proteine) and COL1A2 in skin fibroblasts

  10. Internal mammary artery tissue from active smokers contains decreased amounts of type 1 collagen and decorin (zeige DCN Proteine).

Cow (Bovine) Collagen, Type I, alpha 2 (COL1A2) Interaktionspartner

  1. In advanced stage granulomas in Mycobacterium bovis-infected cattle, there was an increase in the expression of type I procollagen

  2. Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen.

Mouse (Murine) Collagen, Type I, alpha 2 (COL1A2) Interaktionspartner

  1. Identify PDGFRbeta as a driver in activating Akt (zeige AKT1 Proteine)/mTORC1 nexus for high glucose-mediated expression of collagen I (alpha2) in proximal tubular epithelial cells, which contributes to tubulointerstitial fibrosis in diabetic nephropathy.

  2. Insulin receptor substrate-1 (zeige IRS1 Proteine) time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (zeige MLXIP Proteine)-342

  3. Type I collagen was highly expressed in the spinal cord during the scar-forming phase and induced astrocytic scar formation via the integrin-N-cadherin (zeige CDH2 Proteine) pathway.

  4. evidence that FOXL2 (zeige FOXL2 Proteine) modulates Col1a2 transcription through interaction with a response element 65 Kb upstream of the transcription start site

  5. Data indicate that insulin-like growth factor 1 (IGF1 (zeige IGF1 Proteine)) could promote collagen I alpha 2 (COL1A2) expression and osteoblast differentiation in primary pre-osteoblasts by increasing La ribonucleoprotein domain family member 6 (Larp6 (zeige LARP6 Proteine)) expression via a posttranscriptional mechanism.

  6. The phosphorylation sequence matched that targeted by Casein Kinase 2, and inhibition of this kinase activity disrupted the ability of scleraxis to modulate the expression of its target genes while also attenuating TGFbeta (zeige TGFB1 Proteine)-induced expression of type I collagen and myofibroblast phenotype conversion marker genes

  7. Decreased expression of Krox20 (zeige EGR2 Proteine) in mice causes down-regulation of Col1A2 expression, degeneration of the aortic leaflets and disorganization of the extracellular matrix, causing valvular dysfunction.

  8. Resveratrol effectively inhibits collagen I synthesis in IGF-1 (zeige IGF1 Proteine)-stimulated colonic fibroblasts, partly by inhibiting IGF-1R (zeige IGF1R Proteine) activation, and SIRT1 (zeige SIRT1 Proteine) is also responsible for the process.

  9. Sp7/Osterix (zeige SP7 Proteine) induces the mouse Col1a2 expression via the proximal promoter in osteoblastic cells in association with osteoblast differentiation.

  10. Down-regulation let-7 by transforming growth factor-beta1-induced Lin28 (zeige LIN28A Proteine) upregulates collagen expression in glomerular mesangial cells from diabetic mice.

Pig (Porcine) Collagen, Type I, alpha 2 (COL1A2) Interaktionspartner

Zebrafish Collagen, Type I, alpha 2 (COL1A2) Interaktionspartner

  1. ven though in adult bone, skin and scales equal amounts of a1(col1a1a) a2(col1a2) and a3(col1a2)chains are present, the presented data suggest a tissue-specific stoichiometry and/or post-translational modification status for collagen type I

Collagen, Type I, alpha 2 (COL1A2) Protein Überblick

Protein Überblick

This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.

Genbezeichner und Symbole assoziert mit COL1A2

  • collagen type I alpha 2 (LOC100860940)
  • collagen, type 1, alpha 2 (col1a2)
  • collagen, type I, alpha 2 (COL1A2)
  • collagen, type I, alpha 2 (Col1a2)
  • collagen, type I, alpha 2 (col1a2)
  • AA960264 Protein
  • AI325291 Protein
  • alpha2(I) Protein
  • Col1a-2 Protein
  • Cola-2 Protein
  • Cola2 Protein
  • hm:zehn2357 Protein
  • OI4 Protein
  • oim Protein
  • wu:fa98d05 Protein
  • wu:fa99g10 Protein
  • wu:fb04c08 Protein
  • wu:fb11d06 Protein
  • zehn2357 Protein

Bezeichner auf Proteinebene für COL1A2

procollagen, type I, alpha 2 , alpha 2(I) collagen , alpha-2 type I collagen , alpha-2(1) collagen , collagen alpha 2(I) chain , collagen alpha-2(I) chain , alpha 2(I)-collagen , collagen I, alpha-2 polypeptide , collagen of skin, tendon and bone, alpha-2 chain , type I procollagen , COL1A2 gene exons 8 through 12 , type I procollagen pro-alpha 2 chain , alpha 2(I) procollagen , collagen I alpha-2 polypeptide , collagen COL1A2 , osteogenesis imperfecta , alpha 2 type I collagen , collagen a2(I)

GENE ID SPEZIES
100860940 Capra hircus
380419 Xenopus laevis
396243 Gallus gallus
1278 Homo sapiens
403824 Canis lupus familiaris
282188 Bos taurus
100008997 Oryctolagus cuniculus
12843 Mus musculus
84352 Rattus norvegicus
100719158 Cavia porcellus
100626716 Sus scrofa
336471 Danio rerio
100135811 Oncorhynchus mykiss
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