anti-Cofactor of BRCA1 (COBRA1) Antikörper

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). Zusätzlich bieten wir Ihnen COBRA1 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
COBRA1 25920 Q8WX92
COBRA1 311796  
COBRA1 58202 Q8C4Y3
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Showing 10 out of 60 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB <span>COBRA1 Antibody (Center) western blot analysis in 293 cell line lysates (35µg/lane).This demonstrates the COBRA1 antibody detected the COBRA1 protein (arrow).</span> 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert WB COBRA1 Antibody (Center) (ABIN658581) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the COBRA1 antibody detected the COBRA1 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Maus Unkonjugiert WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
357,50 €
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: COBRA1 Antibody [NBP2-15935] - Sample (30 ug of whole cell lysate) A: H1299 5% SDS PAGE gel, diluted at 1:1000. Immunohistochemistry-Paraffin: COBRA1 Antibody [NBP2-15935] - Nucleus on gastric carcinoma; antibody dilution: 1:500. 0.1 mL Anmelden zum Anzeigen 3 bis 6 Tage
341,00 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB IHC-P Image COBRA1 antibody detects COBRA1 protein at nucleus on HBL435 xenograft by immunohistochemical analysis. Sample: Paraffin-embedded HBL435 xenograft. COBRA1 antibody , dilution: 1:500. IHC-P Image COBRA1 antibody detects COBRA1 protein at nucleus on mouse intestine by immunohistochemical analysis. Sample: Paraffin-embedded mouse intestine. COBRA1 antibody , dilution: 1:500. 100 μL Anmelden zum Anzeigen 5 bis 7 Tage
357,24 €
Details
Human Kaninchen Unkonjugiert IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: COBRA1 Antibody [NBP1-05977] - Human placenta. Antibody used at a dilution of 1:200 (1ug/ml). 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
371,00 €
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Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: COBRA1 Antibody [NBP1-82924] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Western Blot: COBRA1 Antibody [NBP1-82924] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells). 0.1 mL Anmelden zum Anzeigen 5 bis 8 Tage
335,00 €
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Human Maus Unkonjugiert WB Western blot of neonatal rat brain lysate showing specific immunolabelingof the 62 kDa COBRA1 protein. Dilution: 1:1000 100 μL Anmelden zum Anzeigen 14 bis 16 Tage
481,97 €
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Human Kaninchen Unkonjugiert WB   100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
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Human Kaninchen Unkonjugiert WB Western blot analysis in 293 cell line lysates (35ug/lane). 400 μL Anmelden zum Anzeigen 6 bis 8 Tage
538,22 €
Details

COBRA1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine)
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Weitere Antikörper gegen COBRA1 Interaktionspartner

Human Cofactor of BRCA1 (COBRA1) Interaktionspartner

  1. High COBRA1 expression is associated with hepatocellular carcinoma.

  2. both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG.

  3. These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A (zeige WHSC2 Antikörper) and NELF-B, relative to other factors in the overall gene induction sequence.

  4. data show that NELF (zeige NELF Antikörper) subunits exhibit highly specific subcellular localizations, such as in NELF (zeige NELF Antikörper) bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF (zeige NELF Antikörper) from cells can lead to enlarged and/or multiple nuclei

  5. NELF-C (zeige TH1L Antikörper) and NELF-D (zeige TH1L Antikörper) are highly related or identical to the protein called TH1 (zeige TH1L Antikörper), of unknown function. NELF-B and NELF-C (zeige TH1L Antikörper) or NELF-D (zeige TH1L Antikörper) are integral subunits that bring NELF-A (zeige WHSC2 Antikörper) and NELF-E (zeige RDBP Antikörper) together. [NELF-B] [NELF-C (zeige TH1L Antikörper)]

  6. COBRA1 may directly modulate AP-1 (zeige FOSB Antikörper) pathway and, therefore, may play important roles in cell proliferation, differentiation, apoptosis, and oncogenesis.

  7. COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines.

  8. Decreasing NELF also correlated with displacement of a positioned nucleosome and increased acetylation of histone H4, suggesting coupling of transcription elongation and chromatin remodeling

  9. Negative elongation factor (NELF (zeige RDBP Antikörper)) is a four subunit transcription factor. Our results point to a surprising role of NELF (zeige NELF Antikörper) in the 3' end processing of histone mRNAs and suggest that NELF (zeige NELF Antikörper) is a new factor that coordinates mRNA processing in transcription.

  10. COBRA1 may coordinate multiple steps in ligand-dependent gene expression, which in turn ensures both the quantity and quality of hormone-stimulated gene products

Mouse (Murine) Cofactor of BRCA1 (COBRA1) Interaktionspartner

  1. This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 (zeige BRCA1 Antikörper) in antagonizing COBRA1-dependent transcription program during mammary gland development.

  2. Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform.

  3. Cobra1 Is Required for TrkC (zeige NTRK3 Antikörper)-Induced Apoptosis.

  4. genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing.

  5. findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes

COBRA1 Antigen-Profil

Protein Überblick

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1\; MIM 603555) and SPT5 (SUPT5H\; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003

Genbezeichner und Symbole assoziert mit COBRA1

  • cofactor of BRCA1 (LOC100219583) Antikörper
  • cofactor of BRCA1 (COBRA1) Antikörper
  • negative elongation factor complex member B (NELFB) Antikörper
  • negative elongation factor complex member B (nelfb) Antikörper
  • cofactor of BRCA1 (cobra1) Antikörper
  • negative elongation factor complex member B (Nelfb) Antikörper
  • negative elongation factor complex member B, Cobra1 (Nelfb) Antikörper
  • A730008L03Rik Antikörper
  • AB041607 Antikörper
  • AI663983 Antikörper
  • bZ1O1.4 Antikörper
  • Cobra1 Antikörper
  • cobra2 Antikörper
  • fe01e12 Antikörper
  • LOC100219583 Antikörper
  • MGC131073 Antikörper
  • Nelf-b Antikörper
  • RGD1307832 Antikörper
  • wu:fe01e12 Antikörper
  • zgc:55628 Antikörper

Bezeichner auf Proteinebene für COBRA1

cofactor of BRCA1 , negative elongation factor B , negative elongation factor B-like , negative elongation factor protein B , ortholog of human cofactor of BRCA1 (COBRA1)

GENE ID SPEZIES
100219583 Taeniopygia guttata
736409 Pan troglodytes
512799 Bos taurus
417254 Gallus gallus
393137 Danio rerio
704966 Macaca mulatta
491230 Canis lupus familiaris
496936 Xenopus (Silurana) tropicalis
734938 Xenopus laevis
100438513 Pongo abelii
100469627 Ailuropoda melanoleuca
100514560 Sus scrofa
100538856 Meleagris gallopavo
100560093 Anolis carolinensis
101103711 Ovis aries
25920 Homo sapiens
311796 Rattus norvegicus
58202 Mus musculus
Ausgewählte Anbieter für anti-COBRA1 (COBRA1) Antikörper
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