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NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). Zusätzlich bieten wir Ihnen COBRA1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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A positively charged face of NELF-AC is involved in RNA binding, whereas the opposite face of the NELF-AC subcomplex binds NELF-B. NELF-B is predicted to form a HEAT repeat fold, also binds RNA in vivo, and anchors the subunit NELF-E (zeige RDBP Antikörper), which is confirmed to bind RNA in vivo.
High COBRA1 expression is associated with hepatocellular carcinoma.
both human and mouse NELF-B proteins are translated from a non-AUG codon upstream of the annotated AUG.
These studies allow us to position the actions of two new modulators of GR-regulated transactivation, NELF-A (zeige WHSC2 Antikörper) and NELF-B, relative to other factors in the overall gene induction sequence.
data show that NELF subunits exhibit highly specific subcellular localizations, such as in NELF bodies or in midbodies, and some shuttle actively between the nucleus and cytoplasm; loss of NELF from cells can lead to enlarged and/or multiple nuclei
NELF-C (zeige TH1L Antikörper) and NELF-D (zeige TH1L Antikörper) are highly related or identical to the protein called TH1 (zeige TH1L Antikörper), of unknown function. NELF-B and NELF-C (zeige TH1L Antikörper) or NELF-D (zeige TH1L Antikörper) are integral subunits that bring NELF-A (zeige WHSC2 Antikörper) and NELF-E (zeige RDBP Antikörper) together. [NELF-B] [NELF-C (zeige TH1L Antikörper)]
COBRA1 may directly modulate AP-1 (zeige FOSB Antikörper) pathway and, therefore, may play important roles in cell proliferation, differentiation, apoptosis, and oncogenesis.
COBRA1 can negatively regulate the activator protein-1 (AP-1) complex at the TFF1 promoter and thus down-regulate TFF1 expression in gastric cancer cell lines.
Decreasing NELF also correlated with displacement of a positioned nucleosome and increased acetylation of histone H4, suggesting coupling of transcription elongation and chromatin remodeling
Negative elongation factor (NELF (zeige RDBP Antikörper)) is a four subunit transcription factor. Our results point to a surprising role of NELF in the 3' end processing of histone mRNAs and suggest that NELF is a new factor that coordinates mRNA processing in transcription.
This study uncovers a previously unappreciated, DNA repair-independent function of BRCA1 (zeige BRCA1 Antikörper) in antagonizing COBRA1-dependent transcription program during mammary gland development.
Human and mouse Nelfb encode proteins translated from a non-AUG (CUG) start codon. The majority of mouse tissues examined express the isoform translated from the CUG start codon, but a small number of tissues also express a shorter isoform of the same apparent size as the AUG-initiated isoform.
Cobra1 Is Required for TrkC (zeige NTRK3 Antikörper)-Induced Apoptosis.
genetic and genomic studies provide new physiological and molecular insight into Nelf-mediated pol II pausing.
findings also indicate that Cobra1 helps maintain the undifferentiated state of mESCs by preventing unscheduled expression of developmental genes
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2\; MIM 606026), either NELFC or NELFD (TH1L\; MIM 605297), and NELFE (RDBP\; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1\; MIM 603555) and SPT5 (SUPT5H\; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003
cofactor of BRCA1
, negative elongation factor B
, negative elongation factor B-like
, negative elongation factor protein B
, ortholog of human cofactor of BRCA1 (COBRA1)