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anti-Coagulation Factor VIII (F8) Antikörper

F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. Zusätzlich bieten wir Ihnen Factor VIII Kits (55) und Factor VIII Proteine (32) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
F8 14069 Q06194
F8 2157 P00451
F8 302470  
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Top anti-Factor VIII Antikörper auf antikoerper-online.de

Showing 10 out of 336 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA Detection limit for recombinant GST tagged F8 is approximately 3 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 12 bis 16 Tage
454,76 €
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: Factor VIII antibody (S2194) [ABIN4493381] - in extracts from HuvEc cells. Immunocytochemistry/Immunofluorescence: Factor VIII Antibody [ABIN4493381] - Factor VIII antibody was tested 1:50 in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
361,00 €
Details
Hund Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded rat tibia tissue labeled with Anti-Factor VIII (FVIII) Polyclonal Antibody (ABIN668601) , Unconjugated at 1:300, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed : Mouse C57 cells labeled with Anti- Factor VIII (FVIII) Polyclonal Antibody (ABIN668601) , Unconjugated at 1:300, followed by conjugation to the secondary antibody was Goat Anti-Rabbit IgG, PE conjugated  at 1:200 for 40 minutes at 37 °C DAPI (5 µg/mL, blue) was used to stain the cell nuclei 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
315,94 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p) Formalin-fixed and paraffin embedded human skin labeled with Anti-Factor VIII Polyclonal Antibody, Unconjugated (ABIN872493) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
315,94 €
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit  Target Name: F8  Sample Tissue: 721_B Whole Cell  Lane A:  Primary Antibody Lane B:  Primary Antibody + Blocking Peptide Primary Antibody Concentration: 1 µg/mL Peptide Concentration: 2 µg/mL Lysate Quantity: 241 µg/laneGel Concentration: 2.12 % 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Hund Kaninchen Unkonjugiert IHC, ELISA, WB 0.1 mg Anmelden zum Anzeigen 6 bis 11 Tage
368,76 €
Details
Human Maus Unkonjugiert EIA, RIA, WB   0.5 mg Anmelden zum Anzeigen 7 bis 9 Tage
605,00 €
Details
Human Kaninchen Unkonjugiert IF (cc), IF (p), IHC (p) Formalin-fixed and paraffin embedded:human colon carcinoma labeled with Anti-factor VIII(FVIII) (human) Polyclonal Antibody (ABIN728000), Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded:human colon carcinoma labeled with Anti-factor VIII(FVIII)(human) Polyclonal Antibody , Unconjugated at 1:200, followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
315,94 €
Details
Human Maus Unkonjugiert EIA, IHC (fro), WB   0.5 mg Anmelden zum Anzeigen 7 bis 9 Tage
495,00 €
Details
Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
298,57 €
Details

F8 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Factor VIII Antikörper

  1. Human Monoclonal Factor VIII Primary Antibody für ELISA - ABIN394620 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010 (PubMed)
    Zeige alle 5 Referenzen für ABIN394620

  2. Dog (Canine) Polyclonal Factor VIII Primary Antibody für IF (p), IHC (p) - ABIN668601 : Yu, Zhang, Jiang, Wang, Zhang: Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. in Molecular medicine reports 2015 (PubMed)
    Zeige alle 3 Referenzen für ABIN668601

  3. Human Monoclonal Factor VIII Primary Antibody für EIA, RIA - ABIN120341 : Rotblat, OBrien, OBrien, Goodall, Tuddenham: Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies. in Biochemistry 1985 (PubMed)
    Zeige alle 2 Referenzen für ABIN120341

  4. Human Monoclonal Factor VIII Primary Antibody für ELISA, WB - ABIN969123 : Shovlin, Sulaiman, Govani, Jackson, Begbie: Elevated factor VIII in hereditary haemorrhagic telangiectasia (HHT): association with venous thromboembolism. in Thrombosis and haemostasis 2007 (PubMed)
    Zeige alle 2 Referenzen für ABIN969123

  5. Human Polyclonal Factor VIII Primary Antibody für IF (p), IHC (p) - ABIN872493 : Tang, Liu, Dong, Li, Li, Hou, Zheng, Lin, Ren: Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts. in Inflammation 2014 (PubMed)
    Zeige alle 2 Referenzen für ABIN872493

  6. Human Polyclonal Factor VIII Primary Antibody für IF (cc), IF (p) - ABIN728000 : Zhou, Zhu, Zou, Wang: Changes in number and biological function of endothelial progenitor cells in hypertension disorder complicating pregnancy. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008 (PubMed)
    Zeige alle 2 Referenzen für ABIN728000

  7. Human Polyclonal Factor VIII Primary Antibody für ICC, IF - ABIN449338 : Zhu, Liu, Miao, Qu, Chi: Enhanced plasma factor VIII activity in mice via cysteine mutation using dual vectors. in Science China. Life sciences 2012 (PubMed)
    Zeige alle 2 Referenzen für ABIN449338

  8. Human Monoclonal Factor VIII Primary Antibody für EIA, IHC (fro) - ABIN112268 : Stel, van der Kwast, Veerman: Detection of factor VIII/coagulant antigen in human liver tissue. in Nature 1983 (PubMed)

  9. Dog (Canine) Polyclonal Factor VIII Primary Antibody für IHC, ELISA - ABIN1582291 : Shen, Li, Chung, Gillies: Retinal vascular changes after glial disruption in rats. in Journal of neuroscience research 2010 (PubMed)

Weitere Antikörper gegen Factor VIII Interaktionspartner

Zebrafish Coagulation Factor VIII (F8) Interaktionspartner

  1. gene is flanked by factor VII (zeige TH Antikörper) and factor X genes; gene encodes a protein homologous to factor VII (zeige TH Antikörper), but lacks critical residues for factor VII (zeige TH Antikörper) activity; functions as an inhibitor of blood coagulation in biochemical assays using zebrafish or human plasmas

Mouse (Murine) Coagulation Factor VIII (F8) Interaktionspartner

  1. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (zeige VWF Antikörper) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

  2. data demonstrate that infusion of platelets containing FVIII triggers neither primary nor memory anti-FVIII immune response in FVIII(null) mice

  3. Both platelet-VWF (zeige VWF Antikörper) and plasma-VWF (zeige VWF Antikörper) are required for optimal platelet-derived FVIII gene therapy for hemophilia A in the presence of inhibitors.

  4. These data support the investigation of FVIII orthologs as treatment modalities in both the congenital and acquired FVIII inhibitor settings.

  5. Activatable bioengineered FIX molecules with FVIII-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.

  6. This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 (zeige LRP1 Antikörper) cluster III.

  7. a fragment containing only approximately 20% of the VWF (zeige VWF Antikörper) sequence is sufficient to support FVIII stability in vivo

  8. Endothelial cells from multiple, but not all, tissues contribute to the plasma FVIII pool in the mouse.

  9. Endothelial cells are the predominant, and possibly exclusive, source of plasma FVIII.

  10. Micro-computed tomography analysis of distal tibia metaphyses also revealed for the first time a major impact of the FVIII/thrombin (zeige F2 Antikörper)/PAR1 (zeige F2R Antikörper) axis on the dynamic bone structure, showing reduced bone.

Human Coagulation Factor VIII (F8) Interaktionspartner

  1. the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (zeige VWF Antikörper) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.

  2. Our finding that the C2-domain of FVIII can be replaced by that of FV without compromising FVIII activity may have translational implications.

  3. Galectin-1 (zeige LGALS1 Antikörper) and Galectin-3 (zeige LGALS3 Antikörper) are novel-binding partners for human FVIII. Gal-1 (zeige LGALS1 Antikörper) binding can influence the procoagulant activity of FVIII.

  4. although fVIII bound avidly to soluble forms of clusters II and IV from LRP1 (zeige LRP1 Antikörper), only soluble cluster IV competed with the binding of fVIII to full-length LRP1 (zeige LRP1 Antikörper), revealing that cluster IV represents the major fVIII binding site in LRP1 (zeige LRP1 Antikörper).

  5. The FVIII B domain variants, p.D963N, p.S806T, p.G873D, p.H998Q and p.Q1225R may be considered as polymorphism or non-pathologic mutations in patients with Haemophilia A.

  6. In this meta-analysis, we have assessed the association between the FXIII-A Val34Leu polymorphism and intracerebral hemorrhage risk. The results of a combined analysis showed no significant association between the FXIII-A Val34Leu polymorphism and ICH (zeige COL4a2 Antikörper) risk in the overall population. The results of this meta-analysis suggest that the FXIII-A Val34Leu polymorphism is not associated with ICH (zeige COL4a2 Antikörper) risk in a Caucasian population.

  7. von Willebrand factor (zeige VWF Antikörper) binds to the surface of dendritic cells and modulates peptide presentation of factor VIII.

  8. Desmopressin acetate increases F8 plasma concentration in patients with combined deficiency of factors V and VIII (zeige COX8A Antikörper).

  9. 37 (70%) of the 53 had discordant antigen-activity ratio, majority of those mutations produced FVIII with low FVIII-specific activity. However, 4 (7.5%) of the 53 mutations produced higher specific activity of FVIII. It is possible that these mutations either produce a secretory defect or an increased metabolic turnover to account for the low levels of FVIII with these mutations.

  10. Platelet-targeted FVIII gene therapy has higher therapeutic efficacy compared to factor VIII replacement therapy may be due to accelerated thrombin (zeige F2 Antikörper) generation.

Pig (Porcine) Coagulation Factor VIII (F8) Interaktionspartner

  1. thrombin (zeige F2 Antikörper) stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Antikörper) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Antikörper) synthesis

  2. cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant

Cow (Bovine) Coagulation Factor VIII (F8) Interaktionspartner

  1. Factor VIIIc (zeige COX7A2 Antikörper) is responsible for tissue invasion during tumor progression.

Factor VIII (F8) Antigen-Profil

Protein Überblick

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Genbezeichner und Symbole assoziert mit F8

  • coagulation factor VIIi (f7i) Antikörper
  • coagulation factor VIII (F8) Antikörper
  • coagulation factor VIII, procoagulant component (F8) Antikörper
  • AHF Antikörper
  • Cf-8 Antikörper
  • Cf8 Antikörper
  • DXS1253E Antikörper
  • F8B Antikörper
  • F8C Antikörper
  • fb61d02 Antikörper
  • FVIII Antikörper
  • HEMA Antikörper
  • wu:fb61d02 Antikörper

Bezeichner auf Proteinebene für F8

Factor VIII , procoagulant component , antihemophilic factor , coagulation factor VIII , coagulation factor VIIIc , factor VIII F8B , coagulation factor VIII, procoagulant component (hemophilia A) , factor VIII , coagulation co-factor

GENE ID SPEZIES
282671 Danio rerio
14069 Mus musculus
2157 Homo sapiens
397339 Sus scrofa
403875 Canis lupus familiaris
100271720 Bos taurus
100303761 Oryctolagus cuniculus
302470 Rattus norvegicus
100359363 Ovis aries
422199 Gallus gallus
Ausgewählte Anbieter für anti-Factor VIII (F8) Antikörper
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