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F8 encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. Zusätzlich bieten wir Ihnen Factor VIII Kits (53) und Factor VIII Proteine (32) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 340 products:
Human Polyclonal Factor VIII Primary Antibody für WB - ABIN3042924
Wu, Chen, Guo, He, Hu: Effects of transforming growth factor-?2 on myocilin expression and secretion in human primary cultured trabecular meshwork cells. in International journal of clinical and experimental pathology 2014
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Human Monoclonal Factor VIII Primary Antibody für ELISA - ABIN394620
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. in Diabetes Care 2010
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Dog (Canine) Polyclonal Factor VIII Primary Antibody für IF (p), IHC (p) - ABIN668601
Yu, Zhang, Jiang, Wang, Zhang: Astragalosides promote angiogenesis via vascular endothelial growth factor and basic fibroblast growth factor in a rat model of myocardial infarction. in Molecular medicine reports 2015
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Human Monoclonal Factor VIII Primary Antibody für EIA, RIA - ABIN120341
Rotblat, OBrien, OBrien, Goodall, Tuddenham: Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies. in Biochemistry 1985
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Human Polyclonal Factor VIII Primary Antibody für ICC, IF - ABIN449338
Zhu, Liu, Miao, Qu, Chi: Enhanced plasma factor VIII activity in mice via cysteine mutation using dual vectors. in Science China. Life sciences 2012
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Human Polyclonal Factor VIII Primary Antibody für IF (p), IHC (p) - ABIN872493
Tang, Liu, Dong, Li, Li, Hou, Zheng, Lin, Ren: Protective Effect of Kaempferol on LPS plus ATP-Induced Inflammatory Response in Cardiac Fibroblasts. in Inflammation 2014
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Human Polyclonal Factor VIII Primary Antibody für IF (cc), IF (p) - ABIN728000
Zhou, Zhu, Zou, Wang: Changes in number and biological function of endothelial progenitor cells in hypertension disorder complicating pregnancy. in Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2008
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Dog (Canine) Polyclonal Factor VIII Primary Antibody für IHC, ELISA - ABIN1582291
Shen, Li, Chung, Gillies: Retinal vascular changes after glial disruption in rats. in Journal of neuroscience research 2010
Human Monoclonal Factor VIII Primary Antibody für EIA, IHC (fro) - ABIN112268
Stel, van der Kwast, Veerman: Detection of factor VIII/coagulant antigen in human liver tissue. in Nature 1983
gene is flanked by factor VII (zeige TH Antikörper) and factor X genes; gene encodes a protein homologous to factor VII (zeige TH Antikörper), but lacks critical residues for factor VII (zeige TH Antikörper) activity; functions as an inhibitor of blood coagulation in biochemical assays using zebrafish or human plasmas
Cytokine release was quantified from FVIII(-/-) splenocytes restimulated with FVIII in the absence or presence of different anti-FcgammaRIIB (CD32) Antibodies (anti-CD32 (zeige FCGR2B PLURAL_@29493@) mAbs) over 6 days.
results revealed localized vascular expression of FVIII and von Willebrand factor (zeige VWF Antikörper) and identified lymphatic endothelial cell as a major cellular source of FVIII in extrahepatic tissues.
the results indicate that residues in the C1 and/or C2 domains of factor VIII are implicated in immunogenic factor VIII uptake, at least in vitro Conversely, in vivo, the binding to endogenous von Willebrand factor (zeige VWF Antikörper) masks the reducing effect of mutations in the C domains on factor VIII immunogenicity.
data demonstrate that infusion of platelets containing FVIII triggers neither primary nor memory anti-FVIII immune response in FVIII(null) mice
Both platelet-VWF (zeige VWF Antikörper) and plasma-VWF (zeige VWF Antikörper) are required for optimal platelet-derived FVIII gene therapy for hemophilia A in the presence of inhibitors.
These data support the investigation of FVIII orthologs as treatment modalities in both the congenital and acquired FVIII inhibitor settings.
Activatable bioengineered FIX molecules with FVIII-independent activity might be a promising tool for improving hemophilia A treatment, especially for patients with inhibitors.
This study demonstrated that FVIIIa interacts with Low-density lipoprotein receptor-related protein 1 (zeige LRP1 Antikörper) cluster III.
a fragment containing only approximately 20% of the VWF (zeige VWF Antikörper) sequence is sufficient to support FVIII stability in vivo
Endothelial cells from multiple, but not all, tissues contribute to the plasma FVIII pool in the mouse.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII by thrombin (zeige F2 Antikörper) has been presented.
Of special importance is the sequential formation of disulfide bonds with different functions in structural support of VWF (zeige VWF Antikörper) multimers, which are packaged, stored and further processed after secretion. Here, all these processes are being reviewed in detail including background information on the occurring biochemical reactions. [review]
The FVIII C1 domain contributes significantly to the immune response against FVIII in acquired and congenital hemophilia inhibitor patients.
the existing epidemiologic investigations with an overview of the range of possible biochemical and immunologic mechanisms that may contribute to the different immune outcomes observed with plasma-derived and recombinant FVIII products.
discuss potential mechanisms through which these intronic SNPs regulate ST3GAL4 (zeige ST3GAL4 Antikörper) biosynthesis and the activity that affects VWF (zeige VWF Antikörper) and FVIII
the half-life of VWF (zeige VWF Antikörper) ( approximately 15 hours) appears to be the limiting factor that has confounded attempts to extend the half-life of rFVIII.
Our finding that the C2-domain of FVIII can be replaced by that of FV without compromising FVIII activity may have translational implications.
Galectin-1 (zeige LGALS1 Antikörper) and Galectin-3 (zeige LGALS3 Antikörper) are novel-binding partners for human FVIII. Gal-1 (zeige LGALS1 Antikörper) binding can influence the procoagulant activity of FVIII.
It was concluded that VEGF and factor VIII are important growth factors associated with fetal development in pigs and are identified in all uterine segments.
thrombin (zeige F2 Antikörper) stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Antikörper) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Antikörper) synthesis
cupredoxin-like A1 subdomains in fVIII contain inter-species differences that are a result of selective pressure on the dissociation rate constant
Factor VIIIc (zeige COX7A2 Antikörper) is responsible for tissue invasion during tumor progression.
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation\; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
, procoagulant component
, antihemophilic factor
, coagulation factor VIII
, coagulation factor VIIIc
, factor VIII F8B
, coagulation factor VIII, procoagulant component (hemophilia A)
, factor VIII
, coagulation co-factor