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F5 encodes an essential cofactor of the blood coagulation cascade. Zusätzlich bieten wir Ihnen Coagulation Factor V Antikörper (120) und Coagulation Factor V Proteine (23) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Coagulation Factor V ELISA Kit für Sandwich ELISA - ABIN415764
Wang, Braun, Zhang, Norström, Thorlacius: Thrombin generation in abdominal sepsis is Rho-kinase-dependent. in Biochemical and biophysical research communications 2015
Show all 2 Pubmed References
Mouse (Murine) Coagulation Factor V ELISA Kit für Sandwich ELISA - ABIN832489
Schlegel, Lesurtel, Melloul, Limani, Tschuor, Graf, Humar, Clavien: ALPPS: from human to mice highlighting accelerated and novel mechanisms of liver regeneration. in Annals of surgery 2014
Platelet-derived FV contributes to the control of angiogenesis and is likely associated with thrombin (zeige F2 ELISA Kits) generation in hind limb ischemia model.
These findings reveal a novel biological function and mechanism of the protein C (zeige PROC ELISA Kits) pathway in which protein S and the aPC (zeige APC ELISA Kits)-cleaved form of fV are cofactors for anti-inflammatory cell signaling by aPC (zeige APC ELISA Kits) in the context of endotoxemia and infection
Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of alpha1-antitrypsin.
The FVL mutation does not influence coagulation activation, lung inflammation or survival in lethal influenza A.
It suggested that there could be a combination of GLA (zeige GLA ELISA Kits) deficiency and FVL or other thrombosis-related gene defect in patients with genetic severe early-onset thrombosis.
Data suggest that tissue factor (zeige F3 ELISA Kits) and factor V induction by LPS (zeige TLR4 ELISA Kits) may in part accelerate mesangioproliferative glomerulonephritis through activation of factor X and downstream proinflammatory and procoagulant mechanisms.
The source of the FVL leading to accelerated thrombosis appears to be circulating, non-platelet-derived plasma FVL.
FVL has the ability to improve the hemophilia A or B phenotype, but this effect is principally evident at the microcirculation level following a particular vascular injury.
observations demonstrate a synergistic interaction between alpha-galactosidase A (zeige GLA ELISA Kits) deficiency and Factor V Leiden toward tissue fibrin deposition; concomitant mutations in these genes may increase the penetrance of vascular thrombotic events in humans
Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers.
Heterozygous FV Leiden, homozygous PAI-1 4G/4G, heterozygous MTHFR C677T, homozygous MTHFR A1298C, as much as the combined thrombophilic genotypes MTHFR 677T + ACE Iota/D, MTHFR 677T/1298C + ACE D/D, ACE I/D + b-fibrinogen -455 G/A, FV HR2 + b-fibrinogen -455 G/A showed a correlation as risk factors for Recurrent pregnancy loss.
the signaling and anticoagulant functions of APC (zeige APC ELISA Kits) are in spatially and kinetically distinct compartments, and that it is possible to specifically inhibit the anticoagulant activity of APC (zeige APC ELISA Kits). Targeting APC (zeige APC ELISA Kits) with a serpin is remarkably effective and may be safe for long-term prophylactic use in the treatment of hemophilia.
Cleavage of FV at Arg(1545) , which abolishes the anticoagulant properties of FV and commits FV to the procoagulant pathway, is inhibited by binding of the TFPIalpha C-terminus to the FV acidic region
The goal of this study was to evaluate the impact of EHR point-of-care tools on medical record documentation of genetic testing care processes for the common HFE mutations, a thrombophilia panel, and HLA-B27.
The prevalence of FVL polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (zeige STXBP1 ELISA Kits)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL mutation with ROP (zeige STXBP1 ELISA Kits) at the end of the study.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (zeige F10 ELISA Kits) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
there is a synergistic effect of the FVL and rs4524 single nucleotide polymorphisms and active cancer on the risk of VTE.
Our finding that the C2-domain of FVIII (zeige F8 ELISA Kits) can be replaced by that of FV without compromising FVIII (zeige F8 ELISA Kits) activity may have translational implications.
These results demonstrate a new anticoagulant (cofactor) function of FV that targets the early phase of coagulation before prothrombinase (zeige F10 ELISA Kits) assembly
There was an increased odds of stillbirth for maternal homozygous factor V Leiden mutation.
Data suggest factor Xa (FXa (zeige F10 ELISA Kits)) and factor Va (FVa) compete to bind FXa (zeige F10 ELISA Kits) on both PS model membranes and microparticles from activated platelets; this competition between dimerization/prothrombinase (zeige FGL2 ELISA Kits) complex formation appears to regulate blood coagulation.
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance.
coagulation factor V
, activated protein C cofactor
, activated protein c cofactor
, coagulation factor V jinjiang A2 domain
, factor V Leiden
, proaccelerin, labile factor