Chromosome 12 Open Reading Frame 5 Proteine (C12orf5)

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. Zusätzlich bieten wir Ihnen Chromosome 12 Open Reading Frame 5 Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
C12orf5 57103 Q9NQ88
Maus C12orf5 C12orf5 319801 Q8BZA9
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Top Chromosome 12 Open Reading Frame 5 Proteine auf antikoerper-online.de

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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   25 μg Anmelden zum Anzeigen 11 bis 12 Tage
$201.60
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Human Unkonjugiert   2 μg Anmelden zum Anzeigen 6 Days
$168.54
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C12orf5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,

Weitere Proteine zu Chromosome 12 Open Reading Frame 5 (C12orf5) Interaktionspartnern

Human Chromosome 12 Open Reading Frame 5 (C12orf5) Interaktionspartner

  1. the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation.

  2. TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine catabolism.

  3. we investigate the crosstalk between PFKFB3 (zeige PFKFB3 Proteine) and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 (zeige PFKFB3 Proteine) knockdown

  4. The study showed that miR (zeige MLXIP Proteine)-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 (zeige PCSK1 Proteine) cell line by decreasing NADPH (zeige NQO1 Proteine) levels by throughly directly binding to 3'-UTR of TIGAR mRNA and repressing TIGAR expression.

  5. This study demonstrated that a high p53 (zeige TP53 Proteine) expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression.

  6. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  7. TIGAR knockdown reduced tumor growth rate.

  8. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (zeige TP53 Proteine) mutation.

  9. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.

  10. The Cdk5 (zeige CDK5 Proteine)-AMT (zeige AMT Proteine) signal pathway involved in regulation of DDR (zeige DDR1 Proteine) by TIGAR.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) Interaktionspartner

  1. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  2. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (zeige TP53 Proteine) or TAp73 (zeige TP73 Proteine).

  3. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  4. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (zeige TXN Proteine) nuclear translocation.

  5. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  6. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  7. p53 (zeige TP53 Proteine)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  8. p53 (zeige TP53 Proteine) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (zeige TP53 Proteine) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) Protein Überblick

Protein Überblick

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Genbezeichner und Symbole assoziert mit C12orf5

  • chromosome 1 open reading frame, human C12orf5 (C1H12ORF5)
  • chromosome 12 open reading frame 5 (c12orf5)
  • chromosome 12 open reading frame 5 (LOC100226990)
  • chromosome 12 open reading frame 5 (C12orf5)
  • chromosome 5 open reading frame, human C12orf5 (C5H12orf5)
  • RIKEN cDNA 9630033F20 gene (9630033F20Rik)
  • AA793651 Protein
  • AI595337 Protein
  • C12orf5 Protein
  • C79710 Protein
  • C85509 Protein
  • FR2BP Protein
  • Tigar Protein

Bezeichner auf Proteinebene für C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPEZIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
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