Chromosome 1 Open Reading Frame 84 Proteine (C1orf84)

The protein encoded by C1orf84 is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. Zusätzlich bieten wir Ihnen Chromosome 1 Open Reading Frame 84 Antikörper (21) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus C1orf84 C1orf84 230676 A2A9C3
C1orf84 23334 Q5T011
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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C1orf84 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Weitere Proteine zu Chromosome 1 Open Reading Frame 84 (C1orf84) Interaktionspartnern

Mouse (Murine) Chromosome 1 Open Reading Frame 84 (C1orf84) Interaktionspartner

  1. in mice that lack SZT2, mTORC1 signalling is increased in several tissues, including (zeige KPTN Proteine)in neurons in the brain

  2. SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment

  3. While the biological function of Szt2 remains unknown, its high conservation, unique structure and effect on seizure threshold suggest that it serves an important role in the central nervous system.

Human Chromosome 1 Open Reading Frame 84 (C1orf84) Interaktionspartner

  1. identification of a protein complex (KICSTOR) that is composed of four proteins, KPTN (zeige KPTN Proteine), ITFG2, C12orf66 and SZT2, and that is required for amino acid or glucose deprivation to inhibit mTORC1 in cultured human cells

  2. SZT2 has a central role in dictating GATOR-dependent nutrient sensing by promoting lysosomal localization of SZT2-orchestrated GATOR complex, and reveal an unexpected function of lysosome-located GATOR2 in suppressing mTORC1 signalling through SESN recruitment

  3. We conclude that the disruption of SZT2 with some residual function might lead to mild or moderate intellectual disability without seizures.

  4. mutations in SZT2 cause a severe type of autosomal-recessive infantile encephalopathy.

Chromosome 1 Open Reading Frame 84 (C1orf84) Protein Überblick

Protein Überblick

The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis.

Genbezeichner und Symbole assoziert mit C1orf84

  • seizure threshold 2 (Szt2)
  • seizure threshold 2 homolog (mouse) (SZT2)
  • 6430407N22 Protein
  • C1orf84 Protein
  • ENSMUSG00000058432 Protein
  • KIAA0467 Protein
  • RP11-506B15.3 Protein
  • SZT2A Protein
  • SZT2B Protein
  • TIGR Protein

Bezeichner auf Proteinebene für C1orf84

Seizure threshold 2 protein , Transcript increased in glutamate resistance , protein SZT2 , seizure threshold 2 protein homolog

GENE ID SPEZIES
230676 Mus musculus
23334 Homo sapiens
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