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CCBP2 encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Zusätzlich bieten wir Ihnen CCBP2 Proteine (4) und CCBP2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal CCBP2 Primary Antibody für IHC (p), ELISA - ABIN4369828
Soler, Humphreys, Spinola, Campbell: CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. in Blood 2003
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Human Monoclonal CCBP2 Primary Antibody für CyTOF, FACS - ABIN4899116
Martinez de la Torre, Buracchi, Borroni, Dupor, Bonecchi, Nebuloni, Pasqualini, Doni, Lauri, Agostinis, Bulla, Cook, Haribabu, Meroni, Rukavina, Vago, Tedesco, Vecchi, Lira, Locati, Mantovani: Protection against inflammation- and autoantibody-caused fetal loss by the chemokine decoy receptor D6. in Proceedings of the National Academy of Sciences of the United States of America 2007
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Data show the structural motifs in the atypical chemokine receptor 2 (ACKR2) are responsible for ligand binding, and suggest ACKR2-derived N-terminal peptides as being of potential therapeutic significance.
engagement of the ACR (zeige ACR Antikörper) D6 by its ligands activates a beta (zeige SUCLA2 Antikörper)-arrestin1 (zeige ARRB1 Antikörper)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein (zeige KPTN Antikörper) cofilin (zeige CFL1 Antikörper) through the Rac1-PAK1 (zeige PAK1 Antikörper)-LIMK1 (zeige LIMK1 Antikörper) cascade.
co-expression of DARC (zeige DARC Antikörper), D6, and CCX-CKR (zeige CCRL1 Antikörper) significantly associated with higher survival in gastric cancer
CCL2 binding to primary adult human astrocytes is CCR2-independent and is likely to be mediated via the D6 decoy.
D6 is expressed in AMs (zeige MAT1A Antikörper) from patients with COPD (zeige ARCN1 Antikörper), and its expression correlates with the degree of functional impairment and markers of immune activation.
Chemokine (zeige CCL1 Antikörper) decoy receptor D6 limits CC-chemokine (zeige CCL1 Antikörper)-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.
DARC (zeige DARC Antikörper) and D6, the most studied members of this group of molecules, are reviewed.
CCR10 (zeige CCR10 Antikörper) is unlikely to be necessary for cutaneous homing of TH cells in the models studied here. CCR10 (zeige CCR10 Antikörper) may instead play a role in the movement of specialized "effector" cutaneous TH cells to and/or within epidermal microenvironments.
CCR10 and its mucosal epithelial ligand CCL28 have roles in the migration of circulating IgA plasmablasts
D6 is constitutively internalized via a ligand-independent, phosphorylation-independent association with beta-arrestin.
a comprehensive model of CCL19 (zeige CCL19 Antikörper) and CCL21 (zeige CCL21 Antikörper) transport and gradient formation in the lymph nodes (LNs) was built; predicts that ACKR4 in LNs prevents CCL19 (zeige CCL19 Antikörper)/CCL21 (zeige CCL21 Antikörper) accumulation in efferent lymph, but does not control intranodal gradients; instead, it attributes the disrupted interfollicular CCL21 (zeige CCL21 Antikörper) gradients observed in Ackr4-deficient LNs to ACKR4 loss upstream
study found that the inflammatory chemokine (zeige CCL1 Antikörper) CCL5 (zeige CCL5 Antikörper) is mostly retained (75%) during the resolution of zymosan A peritonitis in mice; CCL5 (zeige CCL5 Antikörper) exerts a novel proresolving role on macrophages when acting in concert with apoptotic PMN (zeige TBCE Antikörper)-expressed D6.
ACKR4 on stromal cells aids the egress of antigen presenting cells from mouse skin, and, during inflammation, facilitates CCR7 (zeige CCR7 Antikörper)-dependent cell trafficking by scavenging CCL19 (zeige CCL19 Antikörper).
The data shows a novel function for the chemokine receptor CCX-CKR (zeige CCRL1 Antikörper) as a regulator of TGF-beta1 (zeige TGFB1 Antikörper) expression and epithelial-mesenchymal transition in breast cancer cells.
CCRL1 (zeige CCRL1 Antikörper) is expressed in key thymic microenvironments but is dispensable for T lymphopoiesis at steady state in adult mice.
Further examination revealed that proximity of pro-lymphangiogenic macrophages to developing lymphatic vessel surfaces is increased in ACKR2-deficient mice and reduced in CCR2-deficient mice.
stepwise acquisition of chemokine (C-C motif) receptor-like 1 (CCRL1 (zeige CCRL1 Antikörper)) is a late determinant of cortical thymic epithelial cell differentiation
some cells, including plasmacytoid dendritic cells, can express both CCR2 (zeige CCR2 Antikörper) and ACKR2; that Ly6C(high) monocytes have particularly strong CCL2 (zeige CCL2 Antikörper)-scavenging potential in vitro and in vivo; and that CCR2 (zeige CCR2 Antikörper) is a much more effective CCL2 (zeige CCL2 Antikörper) scavenger than ACKR2.
found that lymph node fringes indeed contained physiological gradients of the chemokine (zeige CCL1 Antikörper) CCL21 (zeige CCL21 Antikörper), which depended on the expression of CCRL1 (zeige CCRL1 Antikörper), the atypical receptor for the CCR7 (zeige CCR7 Antikörper) ligands CCL19 (zeige CCL19 Antikörper) and CCL21 (zeige CCL21 Antikörper)
CCX-CKR (zeige CCRL1 Antikörper) deletion increases incidence of a spontaneous Sjogren's syndrome-like pathology, suggestive of a defect in self-tolerance. CCX-CKR (zeige CCRL1 Antikörper)(-/-) mice have fewer thymic epithelial cells per thymocyte, with defects in thymocyte distribution & frequency.
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members\; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes.
C-C chemokine receptor D6
, CC-chemokine-binding receptor JAB61
, chemokine (C-C motif) receptor 9
, chemokine (C-C) receptor 9
, chemokine binding protein 2
, chemokine receptor CCR-10
, chemokine receptor CCR-9
, chemokine receptor D6
, chemokine-binding protein 2
, chemokine-binding protein D6
, CCR10-related receptor
, C-C CKR-11
, C-C chemokine receptor type 11
, CC chemokine receptor-like 1
, CCX CKR
, chemokine (C-C motif) receptor-like 1
, chemokine (C-C) receptor-like 1
, chemokine receptor CCR11
, D6 beta-chemokine receptor