Charged Multivesicular Body Protein 2B Proteine (CHMP2B)

CHMP2B encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. Zusätzlich bieten wir Ihnen CHMP2B Antikörper (69) und CHMP2B Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CHMP2B 25978 Q9UQN3
CHMP2B 68942 Q8BJF9
Ratte CHMP2B CHMP2B 363720  
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Showing 10 out of 10 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$407.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,522.67
Details
Hefe Xenopus tropicalis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,530.00
Details
Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,530.00
Details
Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,530.00
Details
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$467.86
Details

CHMP2B Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Charged Multivesicular Body Protein 2B (CHMP2B) Interaktionspartnern

Human Charged Multivesicular Body Protein 2B (CHMP2B) Interaktionspartner

  1. We directly link TDP-43 (zeige TARDBP Proteine) loss of function toxicity to two genes with rare amyotrophic lateral sclerosis and frontotemporal lobar degeneration-causing mutations, CHMP2B and ErbB4 (zeige ERBB4 Proteine)

  2. these data indicate that the neuronal expression of human CHMP2B(intron5) in areas involved in motor and cognitive functions induces progressive motor alterations associated with dementia symptoms and with histopathological hallmarks reminiscent of both amyotrophic lateral sclerosis and frontotemporal dementia.

  3. Endogenous TMEM106B was partly sequestered in CHMP2B-positive structures. SNP T185 was more associated with CHMP2B than SNP S185, and it enhanced neurotoxicity caused by CHMP2B(Intron5) compared to S185-expressing cells.

  4. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  5. Protein kinase CK2 (zeige CSNK2A1 Proteine) alpha (zeige CSNK2A2 Proteine) is involved in the phosphorylation of the ESCRT-III subunits CHMP3 (zeige CHMP3 Proteine) and CHMP2B, as well as of VPS4B/SKD1 (zeige vps4b Proteine), an ATPase that mediates ESCRT-III disassembly.

  6. Data indicate that knockdown of syntaxin 13 (syx13) further increased the cellular toxicity caused by muaant CHMP2B (CHMP2BIntron5) expression.

  7. CHMP2B immunoreactivity was increased in the dorsal motor nucleus of the vagus nerve in Parkinson's disease and incidental Lewy body disease brains

  8. These findings suggest that endosomal and autophagic pathway is associated with degradation or formation of alpha-synuclein aggregates in alpha-synucleinopathy.

  9. Subjects with CHMP2B mutation show cognitive changes dominated by executive dysfunctions, years before they fulfil diagnostic criteria of FTD (zeige FTL Proteine).

  10. Direct link between disease-causing mutations and the cellular phenotype in cells originating from CHMP2B mutation patients with frontotemporal dementia.

Mouse (Murine) Charged Multivesicular Body Protein 2B (CHMP2B) Interaktionspartner

  1. The presence of early microglial changes in our CHMP2B mutant mice indicates neuroinflammation may be a contributing factor to the neurodegeneration observed in FTD (zeige FTL Proteine).

  2. Study showed that mutant CHMP2B causes the pathological accumulation of endolysosomal components early in the frontotemporal dementia disease course

  3. This study showing that CHMP2B resides at synapses and is involved in synaptic plasticity.

  4. Forebrain-specific expression of frontotemporal dementia-associated mutant CHMP2B in mice causes several age-dependent neurodegenerative phenotypes, including social behavioral impairments.

  5. Chmp2b is one of the most highly regulated cell-autonomous targets of Lbx1 (zeige Lbx1 Proteine) in the embryonic mouse neural tube

  6. These data describe the first mouse model of dementia caused by CHMP2B mutation and provide new insights into the mechanisms of CHMP2B-induced neurodegeneration

CHMP2B Protein Überblick

Protein Überblick

This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration.

Genbezeichner und Symbole assoziert mit CHMP2B

  • charged multivesicular body protein 2B (CHMP2B)
  • charged multivesicular body protein 2Ba (chmp2ba)
  • charged multivesicular body protein 2B pseudogene (LOC747711)
  • charged multivesicular body protein 2B (Chmp2b)
  • charged multivesicular body protein 2Bb (chmp2bb)
  • 1190006E07Rik Protein
  • ALS17 Protein
  • CHMP2.5 Protein
  • chmp2b Protein
  • chmp2bl Protein
  • DMT1 Protein
  • RGD1306781 Protein
  • si:ch211-224m9.5 Protein
  • VPS2-2 Protein
  • VPS2B Protein
  • zgc:77025 Protein

Bezeichner auf Proteinebene für CHMP2B

chromatin modifying protein 2B , charged multivesicular body protein 2b , chmp2b , chromatin-modifying protein 2b , VPS2 homolog B , vacuolar protein-sorting-associated protein 2-2 , chromatin modifying protein 2B, like

GENE ID SPEZIES
487675 Canis lupus familiaris
569532 Danio rerio
747711 Pan troglodytes
100172566 Pongo abelii
100224229 Taeniopygia guttata
25978 Homo sapiens
68942 Mus musculus
363720 Rattus norvegicus
615954 Bos taurus
418461 Gallus gallus
100516044 Sus scrofa
405840 Danio rerio
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