anti-Ceramide Synthase 2 (CERS2) Antikörper

CERS2 encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Zusätzlich bieten wir Ihnen Ceramide Synthase 2 Kits (6) und Ceramide Synthase 2 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CERS2 29956 Q96G23
CERS2 76893 Q924Z4
CERS2 310667  
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Top anti-Ceramide Synthase 2 Antikörper auf antikoerper-online.de

Showing 10 out of 57 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-LASS2 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$412.50
Details
Meerschweinchen Kaninchen Unkonjugiert IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with LASS2 antibody ABIN462181 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Liver (formalin-fixed, paraffin-embedded) stained with LASS2 antibody ABIN462181 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$676.50
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (67.32 KDa) . 200 μL Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details
Meerschweinchen Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat kidney labeled with Anti-Ceramide synthase 2 Polyclonal Antibody, Unconjugated (ABIN709331) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-Ceramide synthase 2 Polyclonal Antibody, Unconjugated  at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$295.90
Details
Human Maus Unkonjugiert WB Western Blot analysis of LASS2 expression in transfected 293T cell line by LASS2 MaxPab polyclonal antibody.<br><br>Lane 1: LASS2 transfected lysate(41.8 KDa).<br>Lane 2: Non-transfected lysate.<br> LASS2 MaxPab polyclonal antibody. Western Blot analysis of LASS2 expression in human placenta. 50 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details

CERS2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-Ceramide Synthase 2 Antikörper

  1. Human Monoclonal CERS2 Primary Antibody für ELISA, WB - ABIN526190 : Separovic, Breen, Joseph, Bielawski, Pierce, VAN Buren, Gudz: Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells. in Anticancer research 2012 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal CERS2 Primary Antibody für WB - ABIN526188 : Jensen, Calvert, Volpert, Kouri, Hurley, Luciano, Wu, Chalastanis, Futerman, Stegh: Bcl2L13 is a ceramide synthase inhibitor in glioblastoma. in Proceedings of the National Academy of Sciences of the United States of America 2014 (PubMed)

Weitere Antikörper gegen Ceramide Synthase 2 Interaktionspartner

Human Ceramide Synthase 2 (CERS2) Interaktionspartner

  1. ASGR1 (zeige ASGR1 Antikörper) can inhibit the activity of V-ATPase (zeige ATP6V1H Antikörper) by interacting with LASS2, thereby suppressing the metastatic potential of hepatoma cells.

  2. Data show that 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9 (zeige AGPAT9 Antikörper)) inhibit cell growth by regulating expression of KLF4 (zeige KLF4 Antikörper)/LASS2/V-ATPase (zeige ATP6V1H Antikörper) proteins in breast cancer.

  3. these results indicate that miR (zeige MLXIP Antikörper)-9 upregulation might be associated with malignant phenotype of bladder cancer. miR (zeige MLXIP Antikörper)-9 promotes chemoresistance of bladder cancer cells by target LASS2.

  4. Data show that CERS2 expression was markedly different between various breast cancer cells and inversely correlated with cell invasion.

  5. silencing of TMSG1 increased V-ATPase (zeige ATP6V1H Antikörper) activity, decreased extracellular pH and in turn the activation of secreted MMP-2 (zeige MMP2 Antikörper), which ultimately promoted metastasis capacity of breast cancer cell.

  6. Results confirmed that TMSG1 is a potential metastasis suppressor gene, and suggested that the mechanism involved the induction of apoptosis and inhibition of cell proliferation via a caspase (zeige CASP3 Antikörper)-dependent mitochondrial pathway.

  7. the vacuolar ATPase (V-ATPase (zeige DNAH8 Antikörper)) activity and extracellular hydrogen ion concentration were significantly decreased and the activity of secreted matrix metalloproteinase-2 (MMP-2 (zeige MMP2 Antikörper)) was downregulated in MCF-7 cells overexpressing LASS2/TMSG1

  8. the inhibitory effect of the LASS2 on growth, invasion and metastasis of prostate cancer cells

  9. Co-expression of CerS2 with CerS4 (zeige CERS4 Antikörper)/CerS6 (zeige CERS6 Antikörper) reversed the inhibitory effect of long chain ceramides on cell proliferation and the induction of apoptosis. we detected no effect on cell proliferation.

  10. expression and role of ceramide synthase-2 in the lung

Mouse (Murine) Ceramide Synthase 2 (CERS2) Interaktionspartner

  1. LASS2 plays an important role in efficient liver regeneration in response to partial hepatectomy.

  2. Deletion of CerS2 strongly reduced very long-chain ceramides (Cer24:0, 24:1) but concomitantly increased long-chain ceramides and sphinganine in plasma and colon tissue. In naive CerS2(-/-) mice, the expression of tight junction proteins including ZO-1 (zeige TJP1 Antikörper) was almost completely lost in the colon epithelium, leading to increased membrane permeability. Ceramide synthase 2 deficiency aggravates dextran induced colitis in mice.

  3. this study shows that Cers2 limits the levels of S1P (zeige S1PR1 Antikörper) in thymus and blood to maintain functional S1P (zeige S1PR1 Antikörper) gradients that mediate thymocyte emigration into the circulation

  4. that only LCBs, the substrates common for all of the CerS isoforms, but not ceramides and complex sphingolipids, were restored to the wild-type levels in the Cers2-rescued Cers1 (zeige CERS1 Antikörper) mutant mouse brains.

  5. CerS1 (zeige CERS1 Antikörper), -2, and -6 are hyperacetylated in the mitochondria of SIRT3 (zeige SIRT3 Antikörper)-null mice.

  6. Haploinsufficiency for this enzyme altered the pattern of ceramide acylation in the liver without affecting total ceramide levels, replacing very-long-chain ceramides with long-chain C16-ceramides.

  7. Development of pheochromocytoma in ceramide synthase 2 null mice

  8. our data strongly indicate that G-CSF (zeige CSF3 Antikörper)-induced CXCR2 (zeige CXCR2 Antikörper) expression is regulated in a CerS2-dependent manner and that CerS2 thereby promotes the migration of neutrophils, thus, contributing to inflammation and the development of EAE and MS.

  9. Data indicate that the augmented rate of death of ceramide synthase 2 (CerS2) null mice is due to elevated levels of tumor necrosis factor alpha (TNFalpha (zeige TNF Antikörper)) secretion as a result of enhanced activity of TNFalpha (zeige TNF Antikörper)-converting enzyme (TACE (zeige ADAM17 Antikörper)).

  10. CerS2-deficient kidneys were completely depleted of phytosphingosine-containing cortical sulfatides without any compensatio

Ceramide Synthase 2 (CERS2) Antigen-Profil

Protein Überblick

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described.

Genbezeichner und Symbole assoziert mit CERS2

  • ceramide synthase 2 (CERS2) Antikörper
  • ceramide synthase 2 (Cers2) Antikörper
  • 0610013I17Rik Antikörper
  • AI225939 Antikörper
  • L3 Antikörper
  • Lass2 Antikörper
  • SP260 Antikörper
  • TMSG1 Antikörper
  • TRH3 Antikörper

Bezeichner auf Proteinebene für CERS2

LAG1 homolog, ceramide synthase 2 , LAG1 longevity assurance 2 , longevity assurance (LAG1, S. cerevisiae) homolog 2 , tumor metastasis-suppressor gene 1 protein , LAG1 longevity assurance homolog 2 , TRAM homolog 3 , longevity assurance homolog 2 , translocating chain-associating membrane protein homolog 3

GENE ID SPEZIES
100055037 Equus caballus
29956 Homo sapiens
483187 Canis lupus familiaris
539223 Bos taurus
76893 Mus musculus
310667 Rattus norvegicus
100156737 Sus scrofa
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