Cell Division Cycle Associated 7-Like Proteine (CDCA7L)

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Zusätzlich bieten wir Ihnen Cell Division Cycle Associated 7-Like Antikörper (45) und Cell Division Cycle Associated 7-Like Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CDCA7L 217946 Q922M5
CDCA7L 619566 Q4G059
CDCA7L 55536 Q96GN5
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$7,759.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,224.83
Details

CDCA7L Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human ,
,

Weitere Proteine zu Cell Division Cycle Associated 7-Like (CDCA7L) Interaktionspartnern

Mouse (Murine) Cell Division Cycle Associated 7-Like (CDCA7L) Interaktionspartner

  1. Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc (zeige MYC Proteine).

Human Cell Division Cycle Associated 7-Like (CDCA7L) Interaktionspartner

  1. We identify the Myc (zeige MYC Proteine)-interacting protein JPO2 and its partner binding protein LEDGF/p75 (zeige PSIP1 Proteine) as critical modulators of PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling and metastasis in medulloblastoma

  2. common LEDGF/p75 (zeige PSIP1 Proteine) interaction interface shared by JPO2, PogZ (zeige POGZ Proteine), MLL1, IWS1 and HIV IN

  3. The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 (zeige IRF4 Proteine) and MYC (zeige MYC Proteine).

  4. Data indicate that JPO2 and LEDGF/p75 (zeige PSIP1 Proteine) interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75 (zeige PSIP1 Proteine).

  5. CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (zeige MAPK3 Proteine) (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC (zeige FAM126A Proteine) progression.

  6. Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A (zeige MAOA Proteine) protein levels within the major depressive disorder groups compared with controls.

  7. monoamine oxidase A (zeige MAOA Proteine) activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 (zeige PSG1 Proteine)

  8. demonstrates the functions of MAO A (zeige MAOA Proteine) and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways

  9. Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 (zeige PSIP1 Proteine)

Cell Division Cycle Associated 7-Like (CDCA7L) Protein Überblick

Protein Überblick

Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Play an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways\; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).

Genbezeichner und Symbole assoziert mit CDCA7L

  • cell division cycle associated 7 like (CDCA7L)
  • cell division cycle associated 7 like L homeolog (cdca7l.L)
  • cell division cycle-associated 7-like protein (LOC100454683)
  • cell division cycle associated 7 like (Cdca7l)
  • BC006933 Protein
  • JPO2 Protein
  • MGC154777 Protein
  • R1 Protein
  • RAM2 Protein
  • RAPGEF5 Protein

Bezeichner auf Proteinebene für CDCA7L

cell division cycle associated 7-like , transcription factor RAM2 , cell division cycle-associated 7-like protein-like , cell division cycle-associated 7-like protein , Rap guanine nucleotide exchange factor (GEF) 5

GENE ID SPEZIES
100067524 Equus caballus
472306 Pan troglodytes
711948 Macaca mulatta
779344 Xenopus laevis
100348574 Oryctolagus cuniculus
100394869 Callithrix jacchus
100454683 Pongo abelii
100472794 Ailuropoda melanoleuca
100585065 Nomascus leucogenys
217946 Mus musculus
619566 Rattus norvegicus
55536 Homo sapiens
420608 Gallus gallus
482347 Canis lupus familiaris
100518624 Sus scrofa
514631 Bos taurus
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