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Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Zusätzlich bieten wir Ihnen Cell Division Cycle Associated 7-Like Antikörper (45) und Cell Division Cycle Associated 7-Like Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse JPO2/RAM2 (Cdca7l) interacts with cMyc (zeige MYC Proteine).
We identify the Myc (zeige MYC Proteine)-interacting protein JPO2 and its partner binding protein LEDGF/p75 (zeige PSIP1 Proteine) as critical modulators of PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) signaling and metastasis in medulloblastoma
common LEDGF/p75 (zeige PSIP1 Proteine) interaction interface shared by JPO2, PogZ (zeige POGZ Proteine), MLL1, IWS1 and HIV IN
The data are consistent with the rs4487645-CDCA7L loci being responsible for the chromosome 7p11.2 association with multiple myeloma risk, probably exerting its effects through an extended pathway involving IRF4 (zeige IRF4 Proteine) and MYC (zeige MYC Proteine).
Data indicate that JPO2 and LEDGF/p75 (zeige PSIP1 Proteine) interact directly and specifically in vivo through the specific interaction domain of JPO2 and the C-terminal domain of LEDGF/p75 (zeige PSIP1 Proteine).
CDCA7L was able to activate the extracellular signal-regulated kinase 1/2 (zeige MAPK3 Proteine) (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting HCC (zeige FAM126A Proteine) progression.
Reduction in R1 repressor protein correlates significantly with an increase (approximately 40%) in monoamine oxidase A (zeige MAOA Proteine) protein levels within the major depressive disorder groups compared with controls.
monoamine oxidase A (zeige MAOA Proteine) activation of glucocorticoids and androgens is regulated differently by R1 and Sp1 (zeige PSG1 Proteine)
demonstrates the functions of MAO A (zeige MAOA Proteine) and its repressor R1(RAM2/CDCA7L/JPO2) in apoptotic signaling pathways
Over-expression of JPO2 resulted in a modest but reproducible inhibition of HIV-1 replication, consistent with competition between integrase and JPO2 for binding to LEDGF/p75 (zeige PSIP1 Proteine)
Plays a role in transcriptional regulation as a repressor that inhibits monoamine oxidase A (MAOA) activity and gene expression by binding to the promoter. Play an important oncogenic role in mediating the full transforming effect of MYC in medulloblastoma cells. Involved in apoptotic signaling pathways\; May act downstream of P38-kinase and BCL-2, but upstream of CASP3/caspase-3 as well as CCND1/cyclin D1 and E2F1 (By similarity).
cell division cycle associated 7-like
, transcription factor RAM2
, cell division cycle-associated 7-like protein-like
, cell division cycle-associated 7-like protein
, Rap guanine nucleotide exchange factor (GEF) 5