Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 4 Proteine (CITED4)

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. Zusätzlich bieten wir Ihnen CITED4 Antikörper (39) und CITED4 Kits (16) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CITED4 56222 Q9WUL8
CITED4 114491 Q99MA0
CITED4 163732 Q96RK1
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Showing 6 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.304,76 €
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.323,97 €
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Hefe Huhn His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.381,59 €
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CITED4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Rat (Rattus)

Human ,
,

Weitere Proteine zu Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 4 (CITED4) Interaktionspartnern

Mouse (Murine) Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 4 (CITED4) Interaktionspartner

  1. Data (including data from knockout mice) suggest Cited4 and CBP/Crebbp (zeige CREBBP Proteine) are required for LH (luteinizing hormone) and MAP kinase (zeige MAPK1 Proteine) signaling to trigger ovulation via regulation of gene expression and histone acetylation in pre-ovulatory follicles.

Human Cbp/p300-Interacting Transactivator, with Glu/Asp-Rich Carboxy-terminal Domain, 4 (CITED4) Interaktionspartner

  1. Upregulation of CITED4 is associated with colorectal cancer.

  2. Demethylation and histone modification can potentially reactivate CITED4 gene expression in some breast cancers and lead to changes in tumour behaviour.

  3. CITED4 functions as a transactivator when artificially targeted to a promoter element. CITED4 physically interacts with all TFAP2 (zeige TFAP2A Proteine) isoforms in vitro and strongly co-activates all TFAP2 (zeige TFAP2A Proteine) isoforms in Hep3B cells.

  4. Results show that breast cancer development is characterized by either nuclear loss or cytoplasmic translocation of CITED4, with consequent loss of hypoxia-inducible factor-1alpha transcriptional antagonist activity.

  5. The interaction and functional cooperation between FHL2 (zeige FHL2 Proteine), CITED4, and CTNNB were studied.

  6. CITED4 is epigenetically silenced in the vast majority of oligodendroglial tumours with 1p and 19q deletions.

  7. mutational study of CITED4 in 24 glial tumors (22 primary glioblastomas, 1 low-grade astrocytoma & its recurrent secondary glioblastoma)

CITED4 Protein Überblick

Protein Überblick

The protein encoded by this intronless gene belongs to the CITED family of transcriptional coactivators that bind to several proteins, including CREB-binding protein (CBP) and p300, via a conserved 32 aa C-terminal motif, and regulate gene transcription. This protein also interacts with transcription factor AP2 (TFAP2), and thus may function as a co-activator for TFAP2. Hypermethylation and transcriptional downregulation of this gene has been observed in oligodendroglial tumors with deletions of chromosomal arms 1p and 19q, and associated with longer recurrence-free and overall survival of patients with oligodendroglial tumors.

Genbezeichner und Symbole assoziert mit CITED4

  • similar to Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal (CITED4)
  • Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (CITED4)
  • Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (LOC100337814)
  • Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (cited4)
  • Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 (Cited4)
  • cCITED3 Protein
  • CITED3 Protein
  • CITED4 Protein
  • MRG-2 Protein
  • Mrg2 Protein

Bezeichner auf Proteinebene für CITED4

similar to Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal , Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 , cbp/p300-interacting transactivator 4 , msg1-related protein 2 , MSG1-related protein 2 , MRG-2 , transcriptional co-activator 4 , cbp/p300-interacting transactivator 3

GENE ID SPEZIES
693978 Macaca mulatta
746795 Pan troglodytes
100337814 Oryctolagus cuniculus
100380001 Xenopus (Silurana) tropicalis
100381097 Xenopus laevis
56222 Mus musculus
114491 Rattus norvegicus
163732 Homo sapiens
504742 Bos taurus
395465 Gallus gallus
101122913 Ovis aries
Ausgewählte Anbieter für CITED4 Proteine (CITED4)
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