Calcium Homeostasis Modulator 1 Proteine (CALHM1)

CALHM1 encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. Zusätzlich bieten wir Ihnen CALHM1 Antikörper (40) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CALHM1 255022 Q8IU99
Ratte CALHM1 CALHM1 499367  
CALHM1 546729  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details

CALHM1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,

Weitere Proteine zu Calcium Homeostasis Modulator 1 (CALHM1) Interaktionspartnern

Human Calcium Homeostasis Modulator 1 (CALHM1) Interaktionspartner

  1. Meta-analysis suggested that CALHM1 rs2986017 might be associated with increased Alzheimer's disease risk in Caucasian, but not Asian population

  2. In the presence of antibody, P86L-CALHM1 shifts the balance between neurodegeneration and neuronal survival toward the stimulation of pro-cytotoxic pathways, thus potentially contributing to its deleterious effects in Alzheimer's disease.

  3. CALHM1 polymorphism may be potential biomarker in patients with Alzheimer disease. [meta-analysis]

  4. The rare R154H variant interferes with CALHM1 control of cytosolic Ca2 (zeige CA2 Proteine)+ and Abeta (zeige APP Proteine) accumulation.

  5. CALHM1 p.P86L variation may not be an AD susceptibility factor in the Han Chinese population.

  6. This study showed that No association between polymorphisms in the calcium homeostasis modulator 1 gene and mesial temporal lobe epilepsy risk in a Chinese population

  7. rare genetic variants in CALHM1 lead to Ca(2 (zeige CA2 Proteine)+) dysregulation and may contribute to the risk of EOAD through a mechanism independent from the classical Ass (zeige ASS1 Proteine) cascade.

  8. The study identifies a previously uncharacterized mechanism of control of Ca(2 (zeige CA2 Proteine)+)-dependent ERK1/2 signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function.

  9. Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.

  10. CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception

Mouse (Murine) Calcium Homeostasis Modulator 1 (CALHM1) Interaktionspartner

  1. Thus, CALHM1 controls synaptic activity in cerebral neurons and is required for the flexible processing of memory in mice.

  2. Abeta (zeige APP Proteine) level reduction by CALHM1 could be explained by an increase in extracellular Abeta (zeige APP Proteine) degradation by insulin-degrading enzyme (zeige IDE Proteine).

  3. Multiple transduction pathways make complex, concentration-dependent contributions to salty taste perception. One of these pathways depends on CALHM1 to detect hypertonic NaCl in the mouth and signal the aversive taste of concentrated salt.

  4. This study demonistrated that the Calhm1 knockot mice consumed only half as much sugar per day as did Wild type mice.

  5. The study identifies a previously uncharacterized mechanism of control of Ca(2 (zeige CA2 Proteine)+)-dependent ERK1/2 signaling in neurons, and further establishes CALHM1 as a critical ion channel for neuronal signaling and function.

  6. Calhm1 was of rare abundance in brain tissues

  7. Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins.

  8. CALHM1 is a voltage-gated ATP-release channel required for sweet, bitter and umami taste perception

  9. CALHM1 is an evolutionarily conserved ion channel family that detects membrane voltage and extracellular Ca(2 (zeige CA2 Proteine)+) levels and plays a role in cortical neuronal excitability and Ca(2 (zeige CA2 Proteine)+) homeostasis

CALHM1 Protein Überblick

Protein Überblick

This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.

Genbezeichner und Symbole assoziert mit CALHM1

  • calcium homeostasis modulator 1 (CALHM1)
  • novel protein similar to vertebrate calcium homeostasis modulator protein family (LOC557535)
  • calcium homeostasis modulator 1 (Calhm1)
  • EG546729 Protein
  • Fam26c Protein
  • RGD1564891 Protein

Bezeichner auf Proteinebene für CALHM1

calcium homeostasis modulator 1 , novel protein similar to vertebrate calcium homeostasis modulator protein family , calcium homeostasis modulator protein 1 , family with sequence similarity 26, member C

GENE ID SPEZIES
466194 Pan troglodytes
486871 Canis lupus familiaris
532026 Bos taurus
557535 Danio rerio
100349950 Oryctolagus cuniculus
100069751 Equus caballus
100601788 Nomascus leucogenys
255022 Homo sapiens
499367 Rattus norvegicus
546729 Mus musculus
428977 Gallus gallus
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