Calcium Channel, Voltage-Dependent, beta 1 Subunit Proteine (CACNB1)

The protein encoded by CACNB1 belongs to the calcium channel beta subunit family. Zusätzlich bieten wir Ihnen CACNB1 Antikörper (117) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CACNB1 782 Q02641
CACNB1 12295 Q8R3Z5
CACNB1 50688 P54283
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Showing 5 out of 7 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.542,70 €
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CACNB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) Interaktionspartnern

Zebrafish Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) Interaktionspartner

  1. beta subunits, probably via the SH3-C-terminal polyproline interaction, adapt a discrete conformation required to modify the alpha1S conformation apt for voltage sensing in skeletal muscle.

  2. Disruption of functional dihydropyridine receptor (zeige CACNA1S Proteine) (DHPR (zeige QDPR Proteine))-ryanodine receptor (zeige RYR3 Proteine) (RyR1 (zeige RYR1 Proteine)) interactions caused by lack of the beta 1a subunit is responsible for paralysis of skeletal muscle in beta 1-null muscle cells.

  3. Relaxed mutant muscles are defective in excitation-contraction coupling. The mutant phenotype results from non-sense mutations in the zebrafish CACNB1 gene that encodes the DHPR (zeige QDPR Proteine) beta1 subunit.

  4. triad expression and facilitation of 1,4-dihydropyridine receptor (zeige CACNA1S Proteine) (DHPR (zeige QDPR Proteine)) charge movement are common features of all tested beta subunits

Human Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) Interaktionspartner

  1. These results provide new insights into the role of muscle-specific (zeige EIF3K Proteine) proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling.

  2. CACNB1, encoding cardiac L-type calcium channel beta 1 subunit, is a potential target for microRNA-328 in transgenic mice.

Mouse (Murine) Calcium Channel, Voltage-Dependent, beta 1 Subunit (CACNB1) Interaktionspartner

  1. Structural and biophysical analyses of the skeletal dihydropyridine receptor (zeige CACNA1S Proteine) beta subunit (zeige POLG Proteine) beta1a reveal critical roles of domain interactions for stability.

  2. These results provide new insights into the role of muscle-specific (zeige EIF3K Proteine) proteins on the structural arrangement of alpha1S intracellular loops and point to a new conformational effect of the beta1a subunit in supporting skeletal muscle excitation-contraction coupling.

  3. The present study reveals that the C-terminal of the beta1a subunit changes conformation in the presence of RyR1 (zeige RYR1 Proteine) consistent with an interaction between the C-terminal of beta1a and RyR1 (zeige RYR1 Proteine) in resting myotubes.

  4. The motif Leu(496)-Leu(500)-Trp (zeige TYRP1 Proteine)(503) within the bet1a C-terminal tail plays a nonessential role in the bidirectional DHPR (zeige QDPR Proteine)/RyR1 (zeige RYR1 Proteine) signaling that supports skeletal-type excitation-contraction coupling.

  5. Cavbeta1a acts as a Cav (zeige CA5A Proteine)-independent regulator of gene expression in MPCs, and is required for their normal expansion during myogenic development.

  6. Data suggest that specific hydrophobic surface residues in calcium channel voltage-dependent beta1a subunit C-terminus bind to RyR1 (zeige RYR1 Proteine) and increase channel activity in lipid bilayers and thus may support skeletal muscle excitation-contraction coupling.

  7. The results of this study indicated that the skeletal muscle DHPR (zeige QDPR Proteine) retrogradely regulates the patterning and formation of the Neuromuscular junction.

  8. Mice with cardiac-specific sequestration of the beta-subunit (zeige POLG Proteine) of the L-type calcium channel

  9. calcium channel beta1a subunits are organized in triad junctions in skeletal muscle

  10. excitation-contraction coupling in skeletal muscle involves the interplay of at least two subunits of the DHPR (zeige QDPR Proteine), namely alpha1S and beta1a, interacting with possibly different domains of RyR1 (zeige RYR1 Proteine) [DHPR (zeige QDPR Proteine) beta1a]

CACNB1 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.

Genbezeichner und Symbole assoziert mit CACNB1

  • calcium channel, voltage-dependent, beta 1 subunit (CACNB1)
  • calcium channel, voltage-dependent, beta 1 subunit (cacnb1)
  • calcium channel, voltage-dependent, beta 1 subunit (Cacnb1)
  • dihydropyridine-sensitive calcium channel beta-subunit (LOC100009109)
  • CAB1 Protein
  • CACNB1 Protein
  • CACNLB1 Protein
  • Cchb1 Protein
  • Cchlb1 Protein
  • zgc:91982 Protein

Bezeichner auf Proteinebene für CACNB1

calcium channel, voltage-dependent, beta 1 subunit , voltage-dependent L-type calcium channel subunit beta-1-like , calcium channel beta1a subunit , dihydropyridine receptor b1 , dihydropyridine receptor beta 1a subunit , dihydropyridine receptor beta 1c subunit , red , relaxed , voltage-dependent L-type calcium channel subunit beta-1 , calcium channel voltage-dependent subunit beta 1 , calcium channel, L type, beta 1 polypeptide , dihydropyridine-sensitive L-type, calcium channel beta-1 subunit , CAB1 , voltage dependent calcium channel, beta1 subunit, variant5 , voltage-dependent calcium channel beta1 subunit , brain calcium channel beta 1 subunit , calcium channel beta 1 subunit

GENE ID SPEZIES
454624 Pan troglodytes
695864 Macaca mulatta
100158521 Xenopus (Silurana) tropicalis
100456553 Pongo abelii
436925 Danio rerio
782 Homo sapiens
491030 Canis lupus familiaris
327703 Bos taurus
12295 Mus musculus
50688 Rattus norvegicus
100127255 Xenopus laevis
100514316 Sus scrofa
100009109 Oryctolagus cuniculus
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