Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit Proteine (CACNA1G)

Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. Zusätzlich bieten wir Ihnen CACNA1G Antikörper (105) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CACNA1G 8913 O43497
Maus CACNA1G CACNA1G 12291  
Ratte CACNA1G CACNA1G 29717 O54898
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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CACNA1G Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Weitere Proteine zu Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit (CACNA1G) Interaktionspartnern

Human Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit (CACNA1G) Interaktionspartner

  1. The results of this study provide support for Cacna1g as a genetic modifier in a mouse model of Dravet syndrome and suggest that Cav3.1 may be a potential molecular target for therapeutic intervention in patients

  2. CACNA1G variant is associated with differential antiepileptic drug response in childhood absence epilepsy.

  3. CaV3.1, CaV3.2 (zeige CACNA1H Proteine) and CaV3.3 (zeige CACNA1I Proteine) channels, are best recognized for their negative voltage of activation and inactivation thresholds that allow them to operate near the resting membrane potential of neurons.

  4. In 2 families with autosomal dominant SCA, a CACNA1G mutation p.Arg1715His was found at S4 of repeat IV, the voltage sensor of the CaV3.1 which shifted it toward a positive potential.

  5. A Recurrent Mutation in CACNA1G Alters Cav3.1 T-Type Calcium-Channel Conduction and Causes Autosomal-Dominant Cerebellar Ataxia (zeige USP14 Proteine).

  6. CaV3.1 channel is required for the generation of a given set of thalamocortical rhythms during unconsciousness. Further, that thalamocortical resonant neuronal activity supported by this channel is important for the control of vigilance states

  7. CaV3.1 downregulation is a major initiating factor for the increased production of the toxic Ab peptide, then the CaV3.1 T-type calcium channel represents a novel target for preventative therapeutics in Alzheimer's disease.

  8. Ethanol affects CaV3.2 (zeige CACNA1H Proteine) but not CaV3.1 nor CaV3.3 (zeige CACNA1I Proteine) channel isoforms.

  9. Cd(2 (zeige CD2 Proteine)) carried sizable inward currents through Ca(v)3.1 channels (210 +/- 20 pA at -60 mV with 2 mM Cd(2 (zeige CD2 Proteine))).

  10. Ca(V)3.1 channels represent a likely pathway for Fe(2) entry into cells.

Mouse (Murine) Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit (CACNA1G) Interaktionspartner

  1. Data, including data from studies using knockout mice, suggest that acetylcholine- (Ach (zeige FGFR3 Proteine)-)induced vasorelaxation/vasodilatation of intrapulmonary arteries is reduced in pulmonary hypertension, but is still dependent on Cav3.1 activity; thus, Cav3.1 contributes to intrapulmonary vascular reactivity by controlling calcium signaling in arterial endothelium and Ach (zeige FGFR3 Proteine)-induced vasorelaxation/vasodilatation.

  2. These results provide support for Cacna1g as an epilepsy modifier gene and suggest that modulation of Cav3.1 may be an effective therapeutic strategy.

  3. Localized Cav3.1 knockdown in the medial septum selectively enhanced object exploration, whereas the null mutant (KO) mice showed enhanced-object exploration as well as open-field exploration.

  4. GluA4 (zeige GRIA4 Proteine) subunits are required to produce an EPSC-triggerable postsynaptic action potentials after the presynaptic action potential, while Cav3.1 expression is needed to establish the driver function of L5B-POm synapses at hyperpolarized membrane potentials

  5. Mice deficient for CaV3.1 were resistant to the induction of experimental autoimmune encephalomyelitis and had reduced productions of the granulocyte-macrophage colony-stimulating factor (zeige CSF2 Proteine) by central nervous system-infiltrating Th1 (zeige HAND1 Proteine) and Th17 cells.

  6. Cross-frequency coupling between low-frequency and gamma rhythms was pronounced in wild-type but not in CaV3.1 knockouts, suggesting that the presence of CaV3.1 channels is a key element in the pathophysiology of trigeminal neuropathic pain.

  7. CaV3.1 and CaV3.2 (zeige CACNA1H Proteine) are substrates for EHD3 (zeige EHD3 Proteine)-dependent protein trafficking in heart

  8. This study reported on the cloning and characterization of a proximal promoter region and initiated the analysis of transcription factors that control CaV (zeige CA5A Proteine) 3.1 channel expression using the murine Cacna1g gene as a model.

  9. Ca(v)3.1-dependent synaptic depression at thalamocortical projections contributes to mechanisms of forward suppression in the auditory cortex

  10. Suggest that T-type Ca(2 (zeige CA2 Proteine)+) channels play an important role in infranodal escape automaticity.

Cow (Bovine) Calcium Channel, Voltage-Dependent, T Type, alpha 1G Subunit (CACNA1G) Interaktionspartner

  1. CaV3.1 structural analysis and comparison to CaV1.2 (zeige CACNA1C Proteine) channel

CACNA1G Protein Überblick

Protein Überblick

Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit CACNA1G

  • calcium channel, voltage-dependent, T type, alpha 1G subunit (CACNA1G)
  • calcium channel, voltage-dependent, T type, alpha 1G subunit (cacna1g)
  • calcium channel, voltage-dependent, T type, alpha 1G subunit (Cacna1g)
  • a1G Protein
  • alpha-1G Protein
  • Ca(v)3.1 Protein
  • Ca(V)T.1 Protein
  • CACNA1G Protein
  • Cav3.1 Protein
  • Cav3.1d Protein
  • mKIAA1123 Protein
  • NBR13 Protein
  • [a]1G Protein

Bezeichner auf Proteinebene für CACNA1G

voltage-dependent calcium channel alpha 1G subunit , calcium channel, voltage-dependent, T type, alpha 1G subunit , calcium channel voltage-dependent T type Cav3.1, alpha 1g subunit , cav3.1c , voltage-dependent T-type calcium channel subunit alpha-1G , voltage-gated calcium channel subunit alpha Cav3.1 , calcium channel, voltage-dependent, alpha 1G subunit

GENE ID SPEZIES
455128 Pan troglodytes
563904 Danio rerio
769385 Gallus gallus
100070000 Equus caballus
100346309 Oryctolagus cuniculus
100462914 Xenopus laevis
8913 Homo sapiens
12291 Mus musculus
29717 Rattus norvegicus
491083 Canis lupus familiaris
282411 Bos taurus
100513431 Sus scrofa
100728128 Cavia porcellus
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