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CD244 encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. Zusätzlich bieten wir Ihnen CD244 Antikörper (134) und CD244 Proteine (27) und viele weitere Produktgruppen zu diesem Protein an.
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The present study provides further insights into the role of the 2B4-CD48 (zeige CD48 ELISA Kits) interaction in the fine regulation of CD8 (zeige CD8A ELISA Kits)(+) T-cell effector function upon antigenic stimulation.
Data show that 2B4 not only can bind to CD48 (zeige CD48 ELISA Kits) in trans but also interacts with CD48 (zeige CD48 ELISA Kits) in cis (zeige CISH ELISA Kits) by using the same binding interface. Also, the results demonstrated that constitutive phosphorylation of 2B4 occurs only in the presence of CD48 (zeige CD48 ELISA Kits), and that cis (zeige CISH ELISA Kits) binding is sufficient to induce substantial levels of baseline phosphorylation.
2B4 expression is increased on CD4 (zeige CD4 ELISA Kits)+ T cells in septic patients
Self-iNKR(-) NK cells in X-linked lymphoproliferative disease 1 patients are functional even in resting conditions, suggesting a role of the inhibitory 2B4/CD48 (zeige CD48 ELISA Kits) pathway in the education process during NK-cell maturation.
our results provide strong evidence that CD244 co-operates with c-Kit (zeige KIT ELISA Kits) to regulate leukemogenesis through SHP-2 (zeige PTPN11 ELISA Kits)/p27 (zeige PAK2 ELISA Kits) signaling.
SLAMF4 gene and surface protein expression was down-regulated in CD8 (zeige CD8A ELISA Kits)+ T cells from SLE patients compared with that in cells obtained from healthy donors. SLAMF4+ effector memory cells produced more granzyme B (zeige Gzmb ELISA Kits) and perforin (zeige PRF1 ELISA Kits) than SLAMF4- cells.
GSK-3 (zeige GSK3b ELISA Kits) undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D (zeige KLRK1 ELISA Kits) and 2B4, either individually or in combination.
Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8 (zeige CD8A ELISA Kits)+ T Cell Hyporesponsiveness to Alloantigen
CD8 (zeige CD8A ELISA Kits)(+) T cells require 2B4 for Epstein-Barr virus-specific immune control, because 2B4 blockade after CD8 (zeige CD8A ELISA Kits)(+) T-cell depletion did not further aggravate symptoms of the infection.
CD244 expression/signaling in tuberculosis correlates with high levels of a long noncoding RNA (lncRNA)-BC050410 [named as lncRNA-AS-GSTT1(1 (zeige GSTT1 ELISA Kits)-72) or lncRNA-CD244] in the CD244(+)CD8 (zeige CD8A ELISA Kits)(+) T-cell subpopulation.
2B4 expression is increased on CD4 (zeige CD4 ELISA Kits)+ T cells in septic animals
2B4 dampens T-independent B cell responses.
DCs from CD244(-/-) mice elicited increased NK cell activation in vitro. These data add CD244 to a growing list of immuno-modulatory receptors found on DCs.
Data show that enforced expression of inhibitor of differentiation protein Id3 (zeige ID3 ELISA Kits) specifically increased the persistence of Cd244 protein 2B4(+) virus-specific CD8 (zeige CD8A ELISA Kits)(+) T cells.
Molecular dynamic simulation explains unbinding and unfolding of CD48 (zeige CD48 ELISA Kits)-2B4 protein complexes.
Signaling via SLAMF4 controls expansion of cytotoxic CD8alphabeta(+) IELs, which regulate the reversible depletion of lamina propria phagocytes and inflammation in the small intestine.
CD244 (2B4) has a regulatory effect on mast cells and eosinophils in murine allergic inflammation.
NKG2D (zeige KLRK1 ELISA Kits) ligation relieves 2B4-mediated NK-cell self-tolerance in mice.
blockade of CD28 (zeige CD28 ELISA Kits) signals in the presence of preserved CTLA-4 (zeige CTLA4 ELISA Kits) signals results in the unique up-regulation of 2B4 on primary CD8 (zeige CD8A ELISA Kits)(+) effectors, and that this 2B4 expression plays a critical functional role in controlling antigen-specific T8 cell responses
In the absence of SAP (zeige APCS ELISA Kits), signaling through the SLAM (zeige SLAMF1 ELISA Kits) family members Ly108 (zeige SLAMF6 ELISA Kits) and 2B4 resulted in increased recruitment of the SHP-1 (zeige PTPN6 ELISA Kits) phosphatase, associated with altered SHP-1 (zeige PTPN6 ELISA Kits) localization and decreased activation of Src (zeige SRC ELISA Kits) kinases at the synapse.
This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CD244 molecule, natural killer cell receptor 2B4
, natural killer cell receptor 2B4
, NK cell activation inducing ligand NAIL
, NK cell activation-inducing ligand
, NK cell type I receptor protein 2B4
, SLAM family member 4
, signaling lymphocytic activation molecule 4
, CD244 natural killer cell receptor 2B4
, non MHC restricted killing associated
, non-MHC restricted killing associated
, transmembrane NK cell receptor 2B4
, NK cell receptor 2B4