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BPTF was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal BPTF Primary Antibody für ELISA, WB - ABIN968990
Landry, Sharov, Piao, Sharova, Xiao, Southon, Matta, Tessarollo, Zhang, Ko, Kuehn, Yamaguchi, Wu: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells. in PLoS genetics 2008
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Human Monoclonal BPTF Primary Antibody für ELISA, WB - ABIN965692
Imamura, Oda, Katahira, Bundo, Pike, Ratcliffe, Kitamura: BLNK binds active H-Ras to promote B cell receptor-mediated capping and ERK activation. in The Journal of biological chemistry 2009
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Human Polyclonal BPTF Primary Antibody für ICC, IF - ABIN188587
Goldman, Garlick, Kingston: Chromatin remodeling by imitation switch (ISWI) class ATP-dependent remodelers is stimulated by histone variant H2A.Z. in The Journal of biological chemistry 2010
Haploinsufficiency of BPTF gene is associated with Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.
Two new signals were observed at genome-wide significance (P < 5 x 10-8), namely, rs7216064 (17q24.3, BPTF), for overall lung adenocarcinoma risk, and rs3817963 (6p21.3, BTNL2 (zeige BTNL2 Antikörper)) which is specific to cases with EGFR (zeige EGFR Antikörper) mutations. In further sub-analyses by EGFR (zeige EGFR Antikörper) status, rs9387478 (ROS1 (zeige ROS1 Antikörper)/DCBLD1) and rs2179920 (HLA-DPB1 (zeige HLA-DPB1 Antikörper)) showed stronger estimated associations in EGFR (zeige EGFR Antikörper)-positive compared to EGFR (zeige EGFR Antikörper)-negative cases
NRP2 (zeige NELL2 Antikörper) inhibits WDFY1 (zeige WDFY1 Antikörper) transcription by preventing the nuclear localization of a transcription factor, Fetal ALZ50-reactive clone 1 (FAC1).
Overexpression of BPTF is associated with melanoma cell survival and progression.
somatic frameshift mutations of BPTF were present in gastric cancer and colorectal cancers
BPTF plays an essential role in cell growth and survival by targeting multiply signaling pathways in human lung cancers
High BPTF expression was significantly correlated with tumor progression and may be a potent prognostic marker of colorectal cancer.
The PHD (zeige PDC Antikörper)-adjacent bromodomain in BPTF binds with marked selectivity H4K16ac, in combination with H3K4me3 at the mononucleosome level.
the novel translocation breakpoint within the BPTF gene is associated with a pre-malignant phenotype
hkelch-like ECH (zeige NFE2L2 Antikörper)-associated protein 1 regulates FAC1 in addition to its known role in control of Nrf2 (zeige GABPA Antikörper)
enhanced activity was observed for individual CD8 (zeige CD8A Antikörper)(+) T-cell clones from mice bearing BPTF-silenced tumors.
These findings therefore reveal a vital role for BPTF in T and Treg cell function and immune homeostasis.
We find that the melanocyte stem cells from these animals are abnormal and that once they are stimulated at anagen, Bptf is required to ensure the expression of melanocyte markers and their differentiation into mature adult melanocytes.
NURF regulation occurs partly through physical and functional interactions with the ubiquitous and multivalent factors Ctcf and cohesin
Results suggest that BPTF/FAC1 is essential in the extraembryonic lineage for correct development of the ectoplacental cone and fetomaternal interactions.
study concludes that Bptf likely regulates genes and signaling pathways essential for the development of key tissues of the early mouse embryo
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely.
bromodomain and PHD domain transcription factor
, bromodomain and PHD finger-containing transcription factor
, fetal Alz-50 clone 1 protein
, fetal Alz-50 reactive clone 1
, fetal Alzheimer antigen
, nucleosome remodeling factor, large subunit
, nucleosome-remodeling factor subunit BPTF
, fetal alzheimer antigen, falz
, bromodomain PHD finger transcription factor
, nucleosome-remodeling factor subunit BPTF-like