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The protein encoded by BAIAP2 has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. Zusätzlich bieten wir Ihnen BAIAP2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.
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Human Monoclonal BAIAP2 Primary Antibody für WB - ABIN1882211
Miyahara, Okamura-Oho, Miyashita, Hoshika, Yamada: Genomic structure and alternative splicing of the insulin receptor tyrosine kinase substrate of 53-kDa protein. in Journal of human genetics 2003
Show all 3 Pubmed References
BAIAP2 is a candidate gene for mediating dendritic spine density abnormalities in schizophrenia. Data suggest that altered DNA methylation (zeige HELLS Antikörper) in schizophrenia may be a mechanism for schizophrenia-related dendritic spine density reductions.
Overexpression of LIN7 or IRSp53 did not prevent the formation of hyperfused mitochondria in cells coexpressing the Drp1 (zeige CRMP1 Antikörper) K38A mutant, thus suggesting that LIN7-IRSp53 complex requires functional Drp1 (zeige CRMP1 Antikörper) to regulate mitochondrial morphology.
Results suggest the hypothesis that defective actin/membrane modulation in IRSp53-deficient dendritic spines may lead to social and cognitive deficits through N-methyl-d-aspartate receptor (zeige GRIN1 Antikörper) dysfunction.
determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
BAIAP2 is related to emotional modulation of human memory strength.
These above results indicated the possible involvement of BAIAP2 in the etiology of attention deficit disorder with hyperactivity, especially ADHD-I.
IRSp53 adopts a closed inactive conformation that opens synergistically with the binding of human Cdc42 (zeige CDC42 Antikörper) to the CRIB (zeige SCRIB Antikörper)-PR and effector proteins, such as the tumor-promoting factor Eps8 (zeige EPS8 Antikörper), to the SH3 domain (zeige ITSN1 Antikörper).
LIN7 is a novel regulator of IRSp53.
mDia1 and WAVE2 (zeige WASF2 Antikörper) are important Src (zeige SRC Antikörper) homology 3 domain partners of IRSp53 in forming filopodia.
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli
CDC42 activation inhibits this activity and promotes IRSp53-dependent recruitment and clustering of VASP to drive actin assembly.
VASP (zeige VASP Antikörper) physically interacted with IRSp53 in NIH-Src (zeige SRC Antikörper) cells and was essential for podosome formation.
propose that IRSp53 is a negative regulator of myogenic differentiation which correlates with the observed down regulation of IRSp53 expression during myoblast differentiation to myotubes
IRSp53, through its interaction with Eps8 (zeige EPS8 Antikörper), not only affects cell migration but also dictates cellular growth in cancer cells.
IRSp53 and spinophilin (zeige PPP1R9B Antikörper) regulate localized Rac (zeige AKT1 Antikörper) activation by T-lymphocyte invasion and metastasis protein 1
In cells spread well on a laminin substrate, IRSp53 was localised at the tips of both lamellipodia and filopodia and in in living cells during protrusion.
Rac1, along with IRSp53 and Abi1 (zeige ABI1 Antikörper), is involved in a more complex and tight regulation of WAVE2 (zeige WASF2 Antikörper) than one operating solely through membrane localization.
Consistent with altered synaptic plasticity, IRSp53-deficient mice exhibit cognitive deficits in the contextual fear-conditioning paradigm
Formation of filopodia is dependent on the Rho family GTPase Cdc42 (zeige CDC42 Antikörper) and the Cdc42 effector (zeige FNBP1L Antikörper) IRSp53 (Baiap2).
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect neuronal growth-cone guidance. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, brain-specific angiogenesis inhibitor 1-associated protein 2
, fas ligand-associated factor 3
, insulin receptor substrate p53/p58
, insulin receptor substrate protein of 53 kDa
, insulin recptor substrate p53
, BAI1-associated protein 2
, BAI-associated protein 2
, brain-specific angiogenesis inhibitor 1-associated protein 2-like
, insulin receptor substrate p53
, insulin receptor tyrosine kinase 53 kDa substrate
, insulin receptor substrate 53
, insulin receptor tyrosine kinase substrate protein p53