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anti-Ataxin 7 (ATXN7) Antikörper

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Zusätzlich bieten wir Ihnen Ataxin 7 Kits (4) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ATXN7 6314 O15265
ATXN7 246103 Q8R4I1
ATXN7 361015  
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Top anti-Ataxin 7 Antikörper auf antikoerper-online.de

Showing 10 out of 51 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Huhn Kaninchen Unkonjugiert WB <b>WB Suggested Anti-ATXN7 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>ACHN cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB Host: Rabbit <br /> Target Name: Atxn7 <br /> Sample Tissue: Rat Small Intestine lysates <br /> Antibody Dilution: 1.0 µg/mL 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of Ataxin 7 expression in A549 (A), NIH3T3 (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 7 bis 8 Tage
464,29 €
Details
Human Kaninchen Unkonjugiert WB ATXN7 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the ATXN7 antibody detected the ATXN7 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
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Human Maus Unkonjugiert ICC, IF, IHC, WB   100 μg Anmelden zum Anzeigen 1 bis 3 Tage
486,11 €
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Human Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Human Kaninchen Unkonjugiert ELISA, WB The Ataxin-7 Antibody is used in Western blot to detect Ataxin 7 in HeLa cell lysates. 0.1 mg Anmelden zum Anzeigen 6 bis 11 Tage
368,76 €
Details
Human Kaninchen Unkonjugiert WB 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
461,56 €
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Human Kaninchen Unkonjugiert WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
484,00 €
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Human Kaninchen FITC ELISA, WB   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.019,69 €
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ATXN7 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität
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Am meisten referenzierte anti-Ataxin 7 Antikörper

  1. Chicken Polyclonal ATXN7 Primary Antibody für WB - ABIN2777891 : Mu, Lin, Chen, Sung, Bai, Jow: The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates. in Pediatrics and neonatology 2009 (PubMed)
    Zeige alle 2 Referenzen für ABIN2777891

  2. Human Monoclonal ATXN7 Primary Antibody für ICC, IF - ABIN2668230 : Yvert, Lindenberg, Picaud, Landwehrmeyer, Sahel, Mandel: Expanded polyglutamines induce neurodegeneration and trans-neuronal alterations in cerebellum and retina of SCA7 transgenic mice. in Human molecular genetics 2000 (PubMed)
    Zeige alle 2 Referenzen für ABIN2668230

Weitere Antikörper gegen Ataxin 7 Interaktionspartner

Human Ataxin 7 (ATXN7) Interaktionspartner

  1. Our study provided the clinico-genetic analysis of nine Indian SCA7 families and CAG repeat (zeige CELF3 Antikörper) distribution analysis in diverse Indian populations showed occurrence of ATXN7-CAG intermediate alleles in a predisposed population

  2. Data show that the aggregates formed by polyQ-expanded ataxin 7 sequester ubiquitin-specific protease (USP22 (zeige USP22 Antikörper)) through specific interactions.

  3. Two pathological polyglutamine proteins, truncated Ataxin-7 and full-length Ataxin-3 (zeige ATXN3 Antikörper), suggest that accumulation of insoluble aggregates beyond a critical threshold could be responsible for neurotoxicity.

  4. The proband exhibited a typical phenotype of SCA7, which includes cone dystrophy and spinocerebellar ataxia (zeige USP14 Antikörper).

  5. Results suggest that sequestration of both enzymatic centers in SAGA upon ATXN7 poly(Q) expansion likely contributes to spinocerebellar ataxia (zeige USP14 Antikörper) type 7 development and progression.

  6. This study shown evidence in vivo, in the SCA7 KI mouse model, that progressive accumulation of mutant ataxin-7 impairs autophagy.

  7. Epidemiological evidence of a SCA7 founder effect in a Mexican population with spinocerebellar ataxia (zeige USP14 Antikörper).

  8. analysis of the founder effect and ancestral origin of the spinocerebellar ataxia (zeige USP14 Antikörper) type 7 mutation in Mexican families

  9. Haplotype and phylogenetic analyses provide evidence showing that the relatively high frequency of SCA7 in Mexican population is the result of a founder mutation and that Mexican SCA7 carriers possess the Western European ancestry.

  10. polyQ-expanded ataxin-7 directly bound the Gcn5 (zeige KAT2A Antikörper) catalytic core of SAGA while in association with its regulatory proteins, Ada2 (zeige TADA2A Antikörper) and Ada3 (zeige TADA3 Antikörper).

Mouse (Murine) Ataxin 7 (ATXN7) Interaktionspartner

  1. Spleen-specific isoform of Pax5 (zeige PAX5 Antikörper) and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.

  2. Results suggest that sequestration of both enzymatic centers in SAGA upon ATXN7 poly(Q) expansion likely contributes to spinocerebellar ataxia (zeige USP14 Antikörper) type 7 development and progression.

  3. we found that HDAC3 (zeige HDAC3 Antikörper) increased the posttranslational modification of normal and expanded ataxin-7.

  4. These results demonstrate that suppression of mutant ataxin-7 expression by only 50% in a polyQ disease model can have a significant impact on disease phenotypes, even when initiated after the onset of detectable behavioral deficits

  5. findings demonstrate that loss of Gcn5 (zeige KAT2A Antikörper) functions can contribute to the time of onset and severity of SCA7 phenotypes, and suggest that non-transcriptional functions of SAGA may play a role in neurodegeneration in this disease

  6. Ataxin-7 gene expression is governed by an antisense ncRNA transcript, SCAANT1, within the ataxin-7 repeat region where the CTCF (zeige CTCF Antikörper) binding sites reside, which regulates a previously unrecognized ataxin-7 sense promoter by convergent transcription.

  7. polyglutamine-expanded ataxin-7 upregulates the expression of Bax (zeige BAX Antikörper) and Puma (zeige BBC3 Antikörper) and causes apoptotic neuronal death by enhancing phosphorylation and transcriptional activity of p53 (zeige TP53 Antikörper).

  8. study suggests that polyglutamine-expanded ataxin-7-induced transcriptional dysregulation causes cerebellar dysfunction and ataxia (zeige USP14 Antikörper)

  9. These results demonstrate an influence of SUMOylation on the multistep aggregation process of ATXN7 and implicate a role for ATXN7 SUMOylation in SCA7 pathogenesis.

  10. glutamine expansion stabilizes mutant ataxin-7, provide an explanation for selective neuronal vulnerability, and show that mutant ataxin-7 impairs posttetanic potentiation (PTP).

Ataxin 7 (ATXN7) Antigen-Profil

Protein Überblick

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the 'pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. This locus has been mapped to chromosome 3, and it has been determined that the diseased allele associated with spinocerebellar ataxia-7 contains 38-130 CAG repeats (near the N-terminus), compared to 7-17 in the normal allele. The encoded protein is a component of the SPT3/TAF9/GCN5 acetyltransferase (STAGA) and TBP-free TAF-containing (TFTC) chromatin remodeling complexes, and it thus plays a role in transcriptional regulation. Alternative splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit anti-Ataxin 7 (ATXN7) Antikörper

  • ataxin 7 (atxn7) Antikörper
  • ataxin 7 (ATXN7) Antikörper
  • ataxin 7 (Atxn7) Antikörper
  • A430107N12Rik Antikörper
  • ADCAII Antikörper
  • AI627028 Antikörper
  • ataxin-7 Antikörper
  • MGC82940 Antikörper
  • OPCA3 Antikörper
  • RGD1562692 Antikörper
  • Sca7 Antikörper

Bezeichner auf Proteinebene für anti-Ataxin 7 (ATXN7) Antikörper

ataxin 7 , ataxin-7 , spinocerebellar ataxia type 7 protein , spinocerebellar ataxia 7 homolog , spinocerebellar ataxia type 7 protein homolog

GENE ID SPEZIES
444398 Xenopus laevis
100127691 Xenopus (Silurana) tropicalis
6314 Homo sapiens
246103 Mus musculus
361015 Rattus norvegicus
416078 Gallus gallus
484701 Canis lupus familiaris
100519688 Sus scrofa
536833 Bos taurus
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