Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) Proteine (ASH2L)

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. Zusätzlich bieten wir Ihnen ASH2L Antikörper (90) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ASH2L 9070 Q9UBL3
ASH2L 23808 Q91X20
Ratte ASH2L ASH2L 290829  
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$8,498.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 20 Days
$860.20
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Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 11 Days
$341.00
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ASH2L Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) (ASH2L) Interaktionspartnern

Human Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) (ASH2L) Interaktionspartner

  1. Data suggest an interplay between megakaryocytic leukemia 1 (MKL1) and ASH2 protein to promote tumor necrosis factor alpha (TNF-alpha (zeige TNF Proteine)) induced proinflammatory transcription in macrophages.

  2. the histone methyltransferase core enzyme ASH2L was bound at EGFR (zeige EGFR Proteine) in the germinal matrix and in gliomas where levels of H3K4me3 are high, and the histone acetyltransferase P300 (zeige EP300 Proteine) was bound in samples with H3K27ac enrichment

  3. Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.

  4. ASH2L enhances ERalpha (zeige ESR1 Proteine) expression as a coactivator of GATA3 (zeige GATA3 Proteine) in breast cancers

  5. Non active site mutations in the MLL1 SET domain render the protein defective for H3K4 dimethylation by the MLL1 core complex, which is associated with a loss of the ability of MLL1 to interact with WRAD or with the RbBP5 (zeige RBBP5 Proteine)/Ash2L heterodimer.

  6. Data indicate that MLL1 methylates Ash2L in the absence of histone H3 (zeige HIST3H3 Proteine), but only when assembled within a complex with WDR5 (zeige WDR5 Proteine) and RbBP5 (zeige RBBP5 Proteine).

  7. H2B dependent regulation of MLL (zeige MLL Proteine) family histone methylatransferases depends on the N-terminal WH motif of ASH2L.

  8. crystal structure of the C-terminal SPRY domain of human Ash2L

  9. The structure shows that Ash2L contains an atypical PHD (zeige PDC Proteine) finger that does not have histone tail-binding activity.

  10. ASH2L binds DNA using a forkhead-like helix-wing-helix (HWH) domain.

Mouse (Murine) Ash2 (Absent, Small, Or Homeotic)-Like (Drosophila) (ASH2L) Interaktionspartner

  1. We discuss the implications of these results to understand the role of ASH2L and Xist repeat E for histone modifications and escape gene regulation during random X-chromosome inactivation.

  2. ASH2L enhances ERalpha (zeige ESR1 Proteine) expression as a coactivator of GATA3 (zeige GATA3 Proteine) in breast cancers

  3. Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells

  4. Tbx1 (zeige TBX1 Proteine) and Ash2l have overlapping mRNA and protein expression patterns during development.

  5. Several candidate targets of complexes containing Ap2delta and Ash2l were identified that can be used to further elucidate their roles during development and showed that Fgfr3 (zeige FGFR3 Proteine) is a novel direct target of these complexes.

  6. Ap2delta associates with ASH2L and MLL2 (ALR), forming a complex that methylates lysine 4 of histone H3.

ASH2L Protein Überblick

Protein Überblick

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity).

Genbezeichner und Symbole assoziert mit ASH2L

  • ASH2 like histone lysine methyltransferase complex subunit (ASH2L)
  • ash2 (absent, small, or homeotic)-like (Drosophila) (Ash2l)
  • ash2 (absent, small, or homeotic)-like (Drosophila) (ash2l)
  • ash2 (absent, small, or homeotic)-like L homeolog (ash2l.L)
  • ASH2 like histone lysine methyltransferase complex subunit (Ash2l)
  • ASH2 Protein
  • ash2-like Protein
  • ASH2L Protein
  • ASH2L1 Protein
  • ASH2L2 Protein
  • Bre2 Protein
  • fb34c06 Protein
  • fe38b04 Protein
  • fi20h02 Protein
  • wu:fb34c06 Protein
  • wu:fe38b04 Protein
  • wu:fi20h02 Protein
  • zgc:171444 Protein

Bezeichner auf Proteinebene für ASH2L

ASH2-like protein , set1/Ash2 histone methyltransferase complex subunit ASH2 , ash2-like

GENE ID SPEZIES
9070 Homo sapiens
23808 Mus musculus
426774 Gallus gallus
558193 Danio rerio
699382 Macaca mulatta
100127317 Xenopus laevis
290829 Rattus norvegicus
475589 Canis lupus familiaris
100138350 Bos taurus
100732899 Cavia porcellus
100059465 Equus caballus
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