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AMOTL2 belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. Zusätzlich bieten wir Ihnen Angiomotin Like 2 Antikörper (19) und Angiomotin Like 2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Amotl2a function in the control of lateral line primordium cell proliferation is mediated together by the Hippo pathway effector Yap1 (zeige YAP1 ELISA Kits) and the Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) effector Lef1 (zeige LEF1 ELISA Kits).
amotL2 associates to the VE-cadherin adhesion complex where it couples adherens junctions to contractile actin fibres.
We demonstrate that amotl2 knockdown in zebrafish wild-type embryos results in embryonic dorsalization, and this effect can be antagonized by co-knockdown of the dorsal inducer beta-catenin2.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Amotl2 interacts preferentially with and facilitates translocation of the phosphorylated c-Src (zeige SRC ELISA Kits), which may in turn regulate the membrane architecture. These data provide the first evidence that amotl2 is essential for cell movements in vertebrate embryos.
these results provide novel insights into a dual tumor suppressive function of AMOTL2 by targeting both YAP (zeige YAP1 ELISA Kits) and AKT (zeige AKT1 ELISA Kits) in liver size control and cancer prevention
study reports for the first time that USP9X (zeige USP9X ELISA Kits) is a deubiquitinase of Angiomotin-like 2 (AMOTL2) and that AMOTL2 mono-ubiquitination is required for YAP (zeige YAP1 ELISA Kits) inhibition
mTORC2 (zeige CRTC2 ELISA Kits)-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP (zeige YAP1 ELISA Kits) signaling.
AmotL2 expression correlates with loss of tissue architecture in tumors from human breast and colon cancer patients.
Scaffold proteins angiomotin (Amot (zeige AMOT ELISA Kits)) and angiomotin (zeige AMOT ELISA Kits)-related AmotL1 (zeige AMOTL1 ELISA Kits) and AmotL2 were recently identified as negative regulators of YAP (zeige YAP1 ELISA Kits) and TAZ (zeige TAZ ELISA Kits) by preventing their nuclear translocation.
These results collectively suggest that the Hippo pathway negatively regulates the actin-binding activity of Amot (zeige AMOT ELISA Kits) family members through direct phosphorylation.
These results demonstrate a role for Amotl2 in synaptic maturation and support the involvement of podosomes in this process.
AMOTL2 interacts with TAZ (zeige TAZ ELISA Kits) and modulates transcriptional activity of TAZ (zeige TAZ ELISA Kits).
AMOTL2 is as a novel activator of LATS2.
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Amot (zeige AMOT ELISA Kits), Amotl1 (zeige AMOTL1 ELISA Kits), and Amotl2 are differentially expressed in uterine cells during the peri (zeige POSTN ELISA Kits)-implantation period.
Data show that MUPP1 (zeige MPDZ ELISA Kits) interacts with angiomotin (Amot (zeige AMOT ELISA Kits)), JEAP (zeige AMOTL1 ELISA Kits)/Amot (zeige AMOT ELISA Kits)-like 1 and MASCOT/Amot (zeige AMOT ELISA Kits)-like 2, and that all the Amot (zeige AMOT ELISA Kits)/JEAP (zeige AMOTL1 ELISA Kits) family proteins also interacted with Patj (zeige INADL ELISA Kits), a close relative of MUPP1 (zeige MPDZ ELISA Kits).
Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motins protein family.
angiomotin like 1
, angiomotin-like protein 1
, angiomotin like 2
, angiomotin-like 2a
, angiomotin-like protein 1-like
, angiomotin-like protein 2-like
, Leman coiled-coil protein
, angiomotin-like protein 2