anti-AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) Antikörper

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Zusätzlich bieten wir Ihnen ALKBH8 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ALKBH8 91801 Q96BT7
ALKBH8 67667 Q80Y20
ALKBH8    
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Top anti-ALKBH8 Antikörper auf antikoerper-online.de

Showing 10 out of 44 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-ALKBH8 Antibody Titration: </b>1.0ug/ml<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-ALKBH8 <br /> Antibody Titration: 1.0 µg/mL <br /> Positive Control: Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$229.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
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Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
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Human Kaninchen Unkonjugiert FACS, IHC (p), WB Formalin-fixed and paraffin-embedded human spleen reacted with ALKBH8 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of ALKBH8 Antibody (C-term) (ABIN390773) in HL60 cell line lysates (35 µg/lane). ALKBH8 (arrow) was detected using the purified polyclonal antibody. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
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Hund Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$493.17
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Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
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Human Kaninchen Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$343.75
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: ALKBH8 Antibody [NBP1-81238] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli & cytoplasm. Western Blot: ALKBH8 Antibody [NBP1-81238] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp.Lane 4: Human plasma (IgG/HSA depleted).Lane 5: Human liver tissue.Lane 6: Human tonsil tissue 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
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Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
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ALKBH8 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine) ,


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Weitere Antikörper gegen ALKBH8 Interaktionspartner

Human AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) Interaktionspartner

  1. findings suggest that the high expression of ALKBH8 is critical for the growth and progression of bladder cancer

  2. Many euk (zeige ALKBH Antikörper)aryotic tRNAs contain the wobble modification 5-m (zeige MCM5 Antikörper)ethoxycarbonylmethyl-uridine (mcm5U). It is demonstrated that (R)- and (S)-5-methoxycarbonylhydroxymethyluridine (mchm5U), hydroxylated forms of mcm(5)U, are present in mammalian tRNA-Arg(UCG), and tRNA-Gly(UCC), respectively. It is shown that the hydroxylation reaction leading to the formation of (S)-mchm5U is catalyzed by the oxygenase (AlkB) domain of ALKBH8.

  3. The methyltransferase domain of ALKBH8 is demonstrated to be a functional homologue of the Saccharomyces cerevisiae Trm9 protein, mediating the last step in the formation of the wobble uridine modification 5-methoxycarbonylmethyl-uridine in tRNA. This modification is shown to be important for efficient selenoprotein synthesis. ALKBH8 knock-out mice are generated and described.

  4. Data show that human AlkB (zeige ALKBH Antikörper) homolog 8 (ABH8) catalyzes tRNA methylation to generate 5-methylcarboxymethyl uridine (mcm(5 (zeige MCM5 Antikörper))U) at the wobble position of certain tRNAs, a critical anticodon loop modification linked to DNA damage survival.

  5. Findings indicate a role for ALKBH8 in urothelial carcinoma cell survival mediated by NOX-1 (zeige NOX1 Antikörper)-dependent ROS (zeige ROS1 Antikörper) signals, further suggesting therapeutic strategies in human bladder cancer by inducing JNK (zeige MAPK8 Antikörper)/p38 (zeige CRK Antikörper)/gammaH2AX (zeige H2AFX Antikörper)-mediated cell death by silencing of ALKBH8.

Mouse (Murine) AlkB, Alkylation Repair Homolog 8 (E. Coli) (ALKBH8) Interaktionspartner

  1. Alkbh8 and tRNA modifications as central regulators of cellular oxidative stress responses in mammalian systems.

  2. The AlkB (zeige ALKBH Antikörper) domain of ALKBH8 specifically hydroxylates mcm(5 (zeige MCM5 Antikörper))U into (S)-mchm(5)U in tRNA-Gly(UCC).

  3. Data show that ALKBH8 is a tRNA methyltransferase required for the final step in the biogenesis of mcm5U.

ALKBH8 Antigen-Profil

Protein Überblick

Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA. Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA. Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys). Required for normal survival after DNA damage. May inhibit apoptosis and promote cell survival and angiogenesis (By similarity).

Genbezeichner und Symbole assoziert mit ALKBH8

  • alkB homolog 8, tRNA methyltransferase (ALKBH8) Antikörper
  • alkB homolog 8, tRNA methyltransferase (Alkbh8) Antikörper
  • 4930562C03Rik Antikörper
  • 8030431D03Rik Antikörper
  • 9430088N01Rik Antikörper
  • Abh8 Antikörper

Bezeichner auf Proteinebene für ALKBH8

AlkB homologue 8 , S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8 , alkylated DNA repair protein alkB homolog 8 , probable alpha-ketoglutarate-dependent dioxygenase ABH8 , tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8

GENE ID SPEZIES
91801 Homo sapiens
489424 Canis lupus familiaris
781788 Bos taurus
67667 Mus musculus
Ausgewählte Anbieter für anti-ALKBH8 (ALKBH8) Antikörper
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